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Synthesis of alginate based silver nanocomposite hydrogels for biomedical applications

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Abstract

Sodium alginate and poly(acrylamide-co-N-vinylcaprolactam-co-acrylamidoglycolic acid) based dual responsive semi-IPN hydrogels (SA-PAVA) were successfully synthesized by free radical redox polymerization. N, N′-Methylene-bis-acrylamide was used as a crosslinker and 5-fluorouracil, an anti-cancer drug, was loaded onto these semi-IPN hydrogels via equilibrium swelling method. The hydrogels were also used as templates for the production of silver nanoparticles by using NaBH4 as reducing agent. In order to understand the polymer-drug interactions, pristine, as well as drug loaded, SA-PAVA hydrogels were characterized by Fourier transform infrared spectroscopy and differential scanning calorimetry. The formation of silver nanoparticles was confirmed by UV-visible spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The swelling behavior of the hydrogel was investigated in distilled water under various pH and temperature conditions. In vitro release of 5-fluorouracil from these SA-PAVA hydrogels was carried out in gastro-intestinal fluids different temperatures. The SA-PAVA hydrogel/silver nanocomposites showed excellent anti-bacterial activity towards Escherichia coli and Bacilli.

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Authors and Affiliations

  1. Department of Chemistry, Yogi Vemana University, Kadapa, 516 003, India

    P. Rama Subba Reddy & K. S. V. Krishna Rao

  2. Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735, Korea

    K. Madhusudana Rao & Chang-Sik Ha

  3. Institute of Chemistry, Far East Department, Russian Academy of Sciences, Vladivostok, Russian Federation

    Yury Shchipunov

Authors
  1. P. Rama Subba Reddy
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  2. K. Madhusudana Rao
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  3. K. S. V. Krishna Rao
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  4. Yury Shchipunov
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  5. Chang-Sik Ha
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Corresponding authors

Correspondence to K. S. V. Krishna Rao or Chang-Sik Ha.

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Reddy, P.R.S., Rao, K.M., Rao, K.S.V.K. et al. Synthesis of alginate based silver nanocomposite hydrogels for biomedical applications. Macromol. Res. 22, 832–842 (2014). https://doi.org/10.1007/s13233-014-2117-7

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  • DOI: https://doi.org/10.1007/s13233-014-2117-7

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