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Synthesis and release behavior of a hybrid of camptothecin intercalated dodecyl sulfate modified layered double hydroxide

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Abstract

The intercalation of a non-ionic and poorly water-soluble drug, camptothecin(CPT), into dodecyl sulfate (DS) modified layered double hydroxide(LDH) was carried out via a secondary intercalation method to obtain a CPT-DS-LDH hybrid. The in vitro CPT release eFxaminations from the hybrid show that the hybrid can well control the release of CPT, which indicates that the hybrid is a potential drug controlled-release system. Moreover, the intercalation kinetics of CPT into the DS modified LDH fits for the pseudo-second-order model. And the release kinetic process of CPT from the CPT-DS-LDH hybrid at pH=4.8 can be described with pseudo-first-order model, while that at pH=7.2 can be described with both pseudo-first-order model and pseudo-second-order model. Meanwhile, the release mechanism of CPT from the CPT-DS-LDH hybrid was discussed.

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Authors and Affiliations

  1. Key Laboratory of Colloid & Interface Chemistry, Ministry of Education, Shandong University, Jinan, 250100, P. R. China

    Yan Li, Na Du & Wanguo Hou

  2. National Engineering Research Center for Colloidal Materials, Shandong University, Jinan, 250100, P. R. China

    Wanguo Hou & Shaojie Liu

Authors
  1. Yan Li
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  2. Na Du
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  3. Wanguo Hou
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  4. Shaojie Liu
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Corresponding author

Correspondence to Shaojie Liu.

Additional information

Supported by the National Natural Science Foundation of China(No.21173135) and the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20110131130008).

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Li, Y., Du, N., Hou, W. et al. Synthesis and release behavior of a hybrid of camptothecin intercalated dodecyl sulfate modified layered double hydroxide. Chem. Res. Chin. Univ. 30, 137–143 (2014). https://doi.org/10.1007/s40242-014-3284-y

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  • DOI: https://doi.org/10.1007/s40242-014-3284-y

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