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Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds

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Abstract

Currently, osteochondral (OC) tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage. However, it is still challenging to ensure the integrity, physiological function and regeneration ability of stratified OC scaffolds in clinical application. Biomimetic OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC tissue. As a consequence, the researches on biomimetic design to achieve the tissue function of each layer, and additive manufacture (AM) to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable progress. In this review, the design methods of biomaterial and structure as well as computer-aided design, and performance prediction of biopolymer-based OC scaffolds are presented; then, the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized; finally, the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds.

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Availability of data and material

The datasets generated in this review are available in Web of Science, and Elsevier Science Direct.

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Acknowledgements

Funding was supported by the Key Research and Development Program of Shaanxi Province (Grant No. 2020ZDLSF04-07), the National Key Research and Development Program of China (Grant No. 2019QY(Y)0502), the National Natural Science Foundation of China (Grant No. 51905438), the Innovation Platform of Biofabrication (Grant No. 17SF0002) and the Fundamental Research Funds for the Central Universities (Grant No. 31020190502009).

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  1. Yanen Wang and Ying Guo have contributed equally to this work.

Authors and Affiliations

  1. Department of Mechanical and Electronic Engineering, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an, 710072, China

    Yanen Wang, Ying Guo, Qinghua Wei, Xinpei Li, Kang Ji & Kun Zhang

  2. Institute of Medical Research, Northwestern Polytechnical University, Xi’an, 710072, China

    Yanen Wang, Ying Guo, Qinghua Wei, Xinpei Li, Kang Ji & Kun Zhang

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  1. Yanen Wang
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  2. Ying Guo
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  3. Qinghua Wei
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  4. Xinpei Li
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  6. Kun Zhang
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YW was involved in conception, supervision and modification; YG helped in preparation, analysis and accomplishment; QW and XL contributed to analysis and modification; KJ and KZ were involved in data category and graph editing.

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Correspondence to Yanen Wang.

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Wang, Y., Guo, Y., Wei, Q. et al. Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds. Bio-des. Manuf. 4, 541–567 (2021). https://doi.org/10.1007/s42242-020-00119-y

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