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Strontium-substituted biphasic calcium phosphate scaffold for orthopedic applications

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Abstract

Strontium ion-substituted calcium phosphate-based ceramic scaffolds enhance osteogenesis. The objective of the present study was to optimize the strontium hydroxyapatite (Sr-HA) and beta tricalcium phosphate (β-TCP) ratio in the fabricated scaffolds to enhance their mechanical strength and bioactivity with controlled biodegradability. Porous polyurethane sponge scaffolds containing Sr-HA and β-TCP in varying concentration were developed by dipping 3D sponge pieces into a slurry containing 10% gelatin, proper concentration of biphasic calcium phosphate (BCP) and 3% poly vinyl alcohol. Four different samples [Sr-BCP, Sr-BCP (20/80), Sr-BCP (30/70), Sr-BCP (40/60)] were prepared and were characterized for biodegradability, water uptake capability and cytotoxicity using various techniques. Pure, crystalline, cytocompatible Sr-BCP Scaffolds possessing both micropores and macropores with porosity greater than 80% and water uptake capability above 100% were obtained. Thus, the effective substitution of Sr-HA and β-TCP in varying proportion makes the composite scaffold a distinctive material of bone tissue engineering.

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Authors and Affiliations

  1. Biomaterials and Tissue Regeneration Laboratory, Centre of Excellence in Theoretical and Mathematical Sciences, Siksha ‘O’ Anusandhan University, Khandagiri Square, Bhubaneswar, Odisha, 751030, India

    Bijayinee Mohapatra & Tapash R. Rautray

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  1. Bijayinee Mohapatra
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  2. Tapash R. Rautray
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Correspondence to Tapash R. Rautray.

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Mohapatra, B., Rautray, T.R. Strontium-substituted biphasic calcium phosphate scaffold for orthopedic applications. J. Korean Ceram. Soc. 57, 392–400 (2020). https://doi.org/10.1007/s43207-020-00028-x

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  • DOI: https://doi.org/10.1007/s43207-020-00028-x

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