2005 | OriginalPaper | Buchkapitel
Profiling and Searching for RNA Pseudoknot Structures in Genomes
verfasst von : Chunmei Liu, Yinglei Song, Russell L. Malmberg, Liming Cai
Erschienen in: Computational Science – ICCS 2005
Verlag: Springer Berlin Heidelberg
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A new method is developed that can profile and efficiently search for pseudoknot structures in noncoding RNA genes. It profiles interleaving stems in pseudoknot structures with independent Covariance Model (CM) components. The statistical alignment score for searching is obtained by combining the alignment scores from all CM components. Our experiments show that the model can achieve excellent accuracy on both random and biological data. The efficiency achieved by the method makes it possible to search for the pseudoknot structures in genomes of a variety of organisms.