Abstract
Medium-sized ring lactams (7- to 15-membered) find widespread use in organic chemistry as key intermediates in the synthesis of more complex structures or as core structures in natural product or pharmaceutically important compounds. Until now, the generation of such rings is still a challenge in organic synthesis. During the past decade an increasing interest has focused on the generation of cyclic peptides as well as hairpin and β-turn mimics and the medium-sized rings were thought to represent suitable fragments. Furthermore, a range of complex natural products is characterized by such lactam structure and their total synthesis is a broad field for organic chemists to test new strategies and to develop new methods.
The aim of the present chapter is to discus some modern strategies to synthesize seven- to fifteen-membered ring lactams, the scope is restricted to the generation to ring systems bearing a single lactam function. Although the range of reactions described concern only the generation of simple structures without complicated stereogenic properties, most of them seem to bear undiscovered potential with regard to stereoselective synthesis. However, the emphasis of the methods is focused on stereoselective processes. The review is subdivided in three major chapters of ring closure reactions and ring enlargements, additional information is given on cycloadditons and fragmentations.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
7 References
a) Hegde VR, Patel MG, Gullo VP, Ganguly AK, Sarre O, Puar MS (1990) J Am Chem Soc 112:6403; b) Hegde VR, Patel MG, Gullo VP, Puar MS (1991) J Chem Soc Chem Commun 810; c) Hegde VR, Patel MG, Gullo VP, Horan AC, King AH (1993) J Antibiot 46:1109; d) Ui H, Imoto M, Umezawa K (1995) J Antibiot 48:387; e) Adamczeski M, Quinoa E, Crews P (1990) J Org Chem 55:240; f) D’Auria MV, Giannini C, Minale L, Zampella A, Debitus C, Frostin M (1997) J Nat Prod 60:814; g) Fernández R, Dherbomez M, Letourneux Y, Nabil M, Verbist JF, Biard JF (1999) J Nat Prod 62:678; h) Groweiss A, Newcomer JJ, O’Keefe BR, Blackman A, Boyd MR (1999) J Nat Prod 62:1691; i) Lane SJ, Marshall PS, Upton RJ, Ratledge C, Ewing M (1995) Tetrahedron Lett 36:4129; j) Velten R, Erdelen C, Gehling M, Göhrt A, Gondol D, Lenz J, Lockhoff O, Wachendorff U, Wendisch D (1998) Tetrahedron Lett 39:1737; k) Lin W, Xu R, Wang R, Mak TCR (1991) J Crystallogr Spectrosc Res 21:189; l) Evans PA, Holmes AB (1991) Tetrahedron 47:9131
a) Keenan RM, Miller WH, Kwon C, Ali FE, Callahan JF, Calvo RR, Hwang SM, Kopple KD, Peishoff CE, Samanen JM, Wong AS, Yuan CK, Huffman WF (1997) J Med Chem 40:2289; b) Angelucci L, Calvisi P, Catini R, Cosentino U, Cozzolino R, de Witt P, Ghirardi O, Giannessi F, Giuliani A, Guaraldi D, Misiti D, Ramacci MT, Scolastico C, Tinti MO (1993) J Med Chem 36:1511; c) Natchus MG, Cheng M, Wahl CT, Pikul S, Almstead NG (1998) Bioorg Med Chem Lett 8:2077; d) Owens TD, Semple Jedward (1998) Bioorg Med Chem Lett 8:3683; e) Semple JE, Minami NK, Tamura SY, Brunck TK, Nutt RF, Ripka WC (1997) Bioorg Med Chem Lett 7:2421 f) Xu Y, Miller MM (1998) J Org Chem 63:4314
a) Mehlfuehrer M, Thirring K, Berner H (1997) J Org Chem 62:4078; b) Belyaev AA (1995) Tetrahedron Lett 36:439
Ugi I, Demharter A, Hoerl W, Schmid T (1996) Tetrahedron 52:11657
a) Nagasaka T, Kato H, Hayashi H, Shioda M, Hikasa H, Hamaguchi F (1990) Heterocycles 30:561; b) Gavagan JE, Fager SK, Fallon RD, Folsom PW, Herkes FE, Eisenberg A, Hann EC, DiCosimo R (1998) J Org Chem 63:4792; c) Lu W, Sih CJ (1999) Tetrahedron Lett 40:4965
a) Nowak W, Gerlach, H (1993) Liebigs Ann Chem 153; b) Winkler JD, Stelmach JE, Siegel MG, Haddad N, Axten J, Dailey WP (1997) Isr J Chem 37:47; c) Erickson SD, Simon JA, Still WC (1993) J Org Chem 58:1305 d) Newlander KA, Callahan JF, Moore ML, Tomaszek TA, Huffman WF (1993) J Med Chem 36:2321; e) Schmidt B, Lindman S, Tong W, Lindeberg G, Gogoll A, Lai Z, Thörnvall M, Synnergren B, Nilsson A, Welch CJ, Sohtell M, Westerlund C, Nyberg F, Karlén A, Hallberg A (1997) J Med Chem 40:903; f) Wipf P, Kim Y, Goldstein DM (1995) J Am Chem Soc 117:11106; g) Amblard M, Daffix I, Berge G, Calmes M, Dodey P, Pruneau D, Paquet JL, Luccarini JM, Belichard P, Martinez J (1999) J Med Chem 42:4193
Mladenova M, Alami M, Linstrumelle G (1995) Synth Commun 25:1401
Mukaiyama T (1979) Angew Chem Int Ed Engl 18:707
Rico I, Halvorsen K, Dubrule C, Lattes A (1994) J Org Chem 59:415
Meyers AI, Knaus G, Kamata K. Ford ME (1976) J Am Chem Soc 98:567
a) Rottmann A, Bartoczek L, Miebscher J (1997) Synthesis 313; b) Bischoff C, Schroeder E (1991) J Prakt Chem 333:181
a) Robl JA, Cimarusti MP (1994) Tetrahedron Lett 35:1393; b) Robl JA, Sulsky R, Sieber-McMaster E, Ryono DE, Cimarusti MP, Simpkins LM, Karanewsky DS, Chao S, Asaad MM, Seymour AA, Fox M, Smith PL, Trippodo NC (1999) J Med Chem 42:305; c) Robl JA, Sieber-McMaster E, Sulsky R (1996) Tetrahedron Lett 37:8985; d) Okayama T, Seki S, Ito H, Takeshima T, Hagiwara M, Morikawa T (1995) Chem Pharm Bull 43:1683
a) Trost BM, Ceschi MA, König B (1997) Angew Chem Int Ed Engl 36:1486; b) Martín M, Mas G, Urpí F, Vilarrasa J (1999) Angew Chem Int Ed 38:3068, (1999) Angew Chem 111:3274; c) Huang W, Kalivretenos AG (1995) Tetrahedron Lett 36:9113
Dutton FE, Lee BH (1998) Ttreahedron Lett 39:5313
Inanaga J, Hirata K, Hiroko S, Katsuki T, Yamaguchi M (1979) Bull Chem Soc Jpn 52:1989
a) Derrer S, Feeder N, Teat SJ, Davies JE, Holmes AB (1998) Tetrahedron Lett 39:9309; b) Long DD, Stetz RJE, Nash RJ, Marguess DG, Lloyd JD, Winters AL, Asano N, Fleet GWJ (1999) J Chem Soc Perkin Trans 1:901; c) Herdeis C, Mohareb RM, Neder RB, Schwabenländer F, Telser J (1999) Tetrahedron Asymmetry 10:4521; d) Michaela Hamerníková M, Pakhomova S, Havlícek J, Hana Votavová H, Kefurt K (2000) Carbohydr Res 325:56
a) Bartra M, Vilarrasa J (1991) J Org Chem 56:5132; b) Bosch I, Romea P, Urpi F, Vilarrasa J (1993) Tetrahedron Lett 34:4671
Hasegawa M, Takabatake T (1991) J Heterocycl Chem 28:1079
Quinkert G, Nestler HP, Schumacher B, del Grosso M, Duerner G, Bats JW (1992) Tetrahedron Lett 33:1977
MaGee DI, Ramaseshan M, Leach JD, (1995) Can J Chem 73:2111
a) Robl JA, Cimarusti MP, Simpkins LM, Weller HN, Pan YY (1994) J Am Chem Soc 116:2348; b) Robl JA, Cimarusti MP, Simpkins LM, Brown B, Ryono DE (1996) J Med Chem 39:494; c) Robl JA (1994) Tetrahedron Lett 35:393
Enders D, Groebner R, Raabe G, Runsink J (1996) Synthesis 941
a) Fox ME, Holmes AB, Forbes IT, Thompson M (1992) Tetrahedron Lett 33:7421; b) Fox ME, Holmes AB, Forbes IT, Thompson M, Ziller JW (1992) Tetrahedron Lett 33:7425; c) Bourque E, Grenon M, Laliberté S, Deslongchamps P (1999) Synlett 1115
M W, Miller ML, Ray PS (1999) Tetrahedron 55:373
a) Johnson EP, Chen GP, Fales KR, Lenk BE, Szendroi RJ, Wang JW, Carlson JA (1995) J Org Chem 60:6595; b) Trost BM, Michellys PY, Gerusz VJ (1997) Angew Chem Int Ed Engl 36:1750
Zhang Z, Ojima I (1993) J Orgmaneot Chem 45:4281
a) Gill GB, Pattenden G, Reynolds SJ (1994) J Chem Soc Perkin Trans 1:369; b) Naito T, Honda Y, Miyata O, Ninomiya I (1995) J Chem Soc Perkin Trans 1:19
a) Lamas C, Saá C, Castedo L, Domínguez D (1992) Tetrahedron Lett 33:5653; b) Rodriguez G, Castedo L, Domínguez D, Saá C (1998) Tetrahedron Lett 39:6551
Lease TG, Shea KJ (1993) J Am Chem Soc 115:2248
For reviews see: Schuster M, Blechert S (1997) Angew Chem Int Ed Engl 36:2036; b) Fürstner A (2000) Angew Chem Int Ed 39:3012
a) Fink BE, Kym PR, Katzenellenbogen JA (1998) J Am Chem Soc 120:4334; b) Rutjes FPJT, Schoemaker HE (1997) Tetrahedron Lett 38:677
a) Houri AF, Xu Z, Cogan DA, Hoveyda AH (1995) J Am Chem Soc 117:2943; b) Xu Z, Johannes CW, Salman SS, Hoveyda AH (1996) J Am Chem Soc 118:10926; c) Xu Z, Johannes CW, Houri AF, La DS, Cogan DA, Hofilena GE, Hoveyda AH (1997) J Am Chem Soc 119:10302
a) Borer BC, Deerenberg S, Bieräuugel H, Pandit UK (1994) Tetrahedron Lett 35:3191; b) Pandit UK, Borer BC Bieräugel H (1997) Pure & Appl Chem 68:659; c) Martin SF, Liao Y, Wong Y, Rein T (1994) Tetrahedron Lett 35:691; d) Martin SF, Chen HJ, Courtney AK, Liao Y, Pätzel M, Ramser MN, Wagman AS (1996) Tetrahedron 52:7251
Goldring WPD, Hodder AS, Weiler L (1998) Tetrahedron Lett 39:4955
a) Maarseveen JHv, den Hartog JAJ, Engelen V, Finner E, Kruse CG (1996) Tetrahedron Lett 37:8249; b) Miller SJ, Blackwell HE, Grubbs RH (1996) J Am Chem Soc 118:9606; c) Piscopio AD, Miller JF, Koch K (1997) Tetrahedron Lett 38:7143; d) Piscopio AD, Miller JF, Koch K (1998) Tetrahedron Lett 39:2667
Aubert T, Farnier M, Guilard R (1990) Synthesis 149
Alonso DA, Falvello LR, Mancheno B, Nájera C, Tomàs M (1996) J Org Chem 61:5004
Baker SR, Parsons AF, Wilson M (1998) Tetrahedron Lett 39:2815
a) Barluenga J, Tomas M, Rubio E, Lopez-Pelegrin JA, Garcia-Granda S, Pertierra P (1996) J Am Chem Soc 118:695; b) Barluenga J, Tomas M, Ballesteros A, Santamaria J, Carbajo RJ, López-Ortiz F, Garcia-Granda S, Pertierra P (1996) Chem Europ J 2:88; c) Barluenga J, Tomas M, Ballesteros A, Santamaria, J, Suarez-Sobrino A (1997) J Org Chem 62:9229
Hansen DW, Peterson KB, Trivedi M, Kramer SW, Webber RK, Tjoeng FS, Moore WM, Jerome GM, Kornmeier CM, Manning PT, Connor JR, Misko TP, Currie MG, Pitzele BS (1998) J Med Chem 41:1361
a) Mukaiyama T, Harada T (1991) Chem Lett 1653; b) Kusama H, Yamashita Y, Narasaka K (1995) Bull Chem Soc Jpn 68:373; c) Laurent A, Jacquault P, Di Martino JL, Hamelin J (1995) J Chem. Soc Chem Commun 1101; d) Baldwin JE, Vollmer HE, Lee V (1999) Tetrahedron Lett 40:5401
Olah GA, Fung AP (1979) Synthesis 473
a) Lyga JW (1996) J Heterocycl Chem 33:1631; b) Mphahlele MJ, Modro TA (1998) J Chem Res Synop 198; c) Wu MH, Jacobsen EN (1997) Tetrahedron Lett 38:1693
a) Gribble GW, Silva RA (1996) Tetrahedron Lett 37:2145; b) Sainsbury M, Mahon MF, Williams CS, Naylor A, Scopes DIC (1991) Tetrahedron 47:4195; c) Diedrichs N, Westermann B (1999) Synlett 1127
a) Olson GL, Voss ME, Hill DE, Kahn M, Madison VS, Cook CM (1990) J Am Chem Soc 112:323; b) Komatsu N, Simizu S, Sugita T (1992) Synth Commun 22:277
a) Toda F, Akai H (1990) J Org Chem 55:4973; b) Toda F, Mori K, Matsuura Y, Akai H (1990) J Chem Soc Chem Commun 1591
a) Kalgutkar AS, Crews BC, Marnett LJ (1996) J Med Chem 39:1692; b) Hoffmann RV, Salvador JM (1991) Tetrahedron Lett 32:2429; c) Vedejs E, Sano H (1992) Tetrahedron Lett 33:3261; d) Evans PA, Modi DP (1995) J Org Chem 60:6662
a) MacPherson LJ, Bayburt EK, Capparelli MP, Bohacek RS, Clarke FH, Ghai RD, Sakane Y, Berry CJ, Peppard JV, Trapani AJ (1993) J Med Chem 36:3821; b) Stanton JL, Sperbeck DM, Trapani AJ, Cote D, Sakane Y, Berry CJ, Ghai RD (1993) J Med Chem 36:3829; c) Aubé J, Milligan GL, Mossman CJ (1992) J Org Chem 57:1635; d) DeVita RJ, Goulet MT, Wyvratt MJ, Fisher MH, Lo JL, Yang YT, Cheng K, Roy G (1999) Bioorg Med Chem Lett 9:2621
a) Gracias V, Milligan GL, Aubé J (1996) J Org Chem 61:10; b) Gracias V, Frank KE, Milligan GL, Aubé J (1997) Tetrahedron 53:16241; c) Forsee JE, Smith BT, Frank KE, Aubé J (1998) Syn Lett 1258 d) Forsee JE, Aubé J (1999) J Org Chem 64:4381
a) Milligan GL, Mossman CJ, Aubé J (1995) J Am Chem Soc 117:10449; b) LeDreau MA, Desmaële D, Dumas F, d’Angelo J (1993) J Org Chem 58:2933; c) Mossman CJ, Aubé J (1996) Tetrahedron 52:3403
a) Aubé J, Wang Y, Hammond M, Tanol M, Takusagawa F, Vander Velde D (1990) J Am Chem Soc 112:4879; b) Aubé J, Hammond M, Gherardini E, Takusagawa F (1991) J Org Chem 56:499; c) Kitagawa O, Vander Velde D, Dutta D, Morton M, Takusagawa F, Aubé J (1995) J Am Chem Soc 117:5169; d) Wolfe MS, Dutta D, Aubé J (1997) J Org Chem 62:654; e) Suda K, Sashima M, Izutsu M, Hino F (1994) J Chem Soc Chem Commun 949
Endo Y, Kataoka K, Haga N, Shudo K (1992) Tetrahedron Lett 33:3339
a) Evans PA, Holmes AB, Russell K (1990) Tetrahedron Asymmetry 1:593; b) Evans PA, Holmes AB, Russell K (1992) Tetrahedron Lett 33:6857; c) Evans PA, Holmes AB, Russell K (1994) J Chem Soc Perkin Trans 1:3397; d) Evans PA, Holmes AB, Collins I, Raithby PR, Russell K (1995) J Chem Soc Chem Commun 2325; e) Evans PA, Holmes AB, McGeary RP, Nadin A, Russell K, O’Hanlon PJ, Pearson ND (1996) J Chem Soc Perkin Trans 1:123; f) Evans PA, Collins I, Hamley P, Holmes AB, Raithby PR, Russel K (1992) Tetrahedron Lett 33:6859
Müller P, Imogai H (1999) Helv Chim Acta 82:315
Lindstroem UM, Somfai P (1997) J Am Chem Soc 119:8385
a) Suh YG, Lee JY, Kim SA, Jung JK (1996) Synth Commun 26:1675; b) Suh YG, Kim SA, Jung JK, Shin DY, Min KH, Koo BA, Kim HS (1999) Angew Chem Int Ed 38:3545
a) Edstrom ED (1991) J Am Chem Soc 113:6690; b) Edstrom ED (1991) Tetrahedron Lett 32:5709
a) Diederich M, Nubbemeyer U (1995) Angew Chem Int Ed Engl 34:1026; b) Diederich M, Nubbemeyer U (1996) Chem Europ J 2:894; c) Sudau A, Nubbemeyer U (1998) Angew Chem Int Ed Engl 37:1140; d) Laabs S, Scherrmann A, Sudau A, Diederich M, Kierig C, Nubbemeyer U (1999) Synlett 25; e) Sudau A, Münch W, Nubbemeyer U, Bats JW (2000) J Org Chem 65:1710
a) White DNJ, Bovill MJ (1977) J Chem Soc Perkin Trans II 1610; b) Guella G, Chiasera G, N’Diaye I, Pietra F (1994) Helv Chim Acta 77:1203; c) Deiters A, Mück-Lichtenfeld C, Fröhlich R, Hoppe D (2000) Org Lett 2:2415
a) Sudau A, Münch W, Nubbemeyer U, Bats JW (2001) Chem Eur J 7:611; b) Diederich M, Nubbemeyer U (1999) Synthesis 286
Deur CJ, Miller MW, Hegedus LS (1996) J Org Chem 61:2871
Lee J, Ha, JD, Cha JK (1997) J Am Chem Soc 119:8127
Kraft A (1999) J Chemoc SPerkin Trans I 705
Sofan MA, Mashaly MM, El-Shamy NY, El-Hossini MS (1997) Pol J Chem 71:196
a) Franzisket L, Heesing A (1991) Chem Ber 124:635; b) Sano T, Horiguchi Y, Tsuda Y (1990) Chem Pharm Bull 38:3283; c) Sano T, Enomoto H, Kurebayashi Y, Horiguchi Y, Tsuda Y (1993) Chem Pharm Bull 41:471; d) Fu TY, Scheffer JR, Trotter J (1994) Can J Chem 72:1952; e) Kollenz G, Terpetschnig E, Sterk H, Peters K, Peters EM (1999) Tetrahedron 55:2973
a) Lamara K, Smalley RK (1991) Tetrahedron 47:2277; b) Lamara K, Redhouse AD, Smalley RK, Thompson JR (1994) Tetrahedron 50:5515
a) Al-Jalal NA (1990) J Heterocycl Chem 27:1323; b) Al-Jalal NA (1995) J Chem Res Synop 256
a) Ognyanov VI, Hesse M (1990) Helv Chim Acta 73:272; b) Koch T, Hesse M (1992) Synthesis 931; c) Koch T, Hesse M (1994) Helv Chim Acta 77:819; d) Ivancev W, Ognyanov VI, Hesse M (1996) Tetrahedron 52:4363
a) Benati L, Nanni D, Sangiorgi C, Spagnolo P (1999) J Org Chem 64:7836; b) Kim S, Joe GH, Do JY (1993) J Am Chem Soc 115:3328
Wipf P, Li W (1999) J Org Chem 64:4576
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Nubbemeyer, U. (2001). Synthesis of Medium-Sized Ring Lactams. In: Metz, P. (eds) Stereoselective Heterocyclic Synthesis III. Topics in Current Chemistry, vol 216. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-44726-1_4
Download citation
DOI: https://doi.org/10.1007/3-540-44726-1_4
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-41763-7
Online ISBN: 978-3-540-44726-9
eBook Packages: Springer Book Archive