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Mechanisms of toxic metal tolerance in yeast

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Molecular Biology of Metal Homeostasis and Detoxification

Part of the book series: Topics in Current Genetics ((TCG,volume 14))

Abstract

Toxic metals are an integral part of our environment and all organisms possess systems to evade toxicity and acquire tolerance. Studies in yeast have revealed a number of important tolerance systems encompassing metal uptake and export pathways, metal binding and sequestration systems as well as the regulatory mechanisms that the cell utilizes to control these systems. The study of the physiological, molecular, and genetic details of the function of these systems has significantly contributed to our understanding of toxic metal tolerance acquisition. This review will focus on tolerance mechanisms to toxic metals including cadmium, arsenic, antimony, mercury, and selenium in the model eukaryote Saccharomyces cerevisiae (bakers’ yeast) and other fungi.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology/Microbiology, Göteborg University, S-405 30 Göteborg, Sweden

    Markus J. Tamás

  2. Service de Biochimie et de Génétique Moléculaire, DBJC, CEA/Saclay, 91191 Gif-sur-Yvette, France

    Jean Labarre

  3. Laboratoire Stress Oxydants et Cancer, Service de Biologie Moléculaire Systemique, DBJC, DSV, CEA-Saclay, 91191 Gif-sur-Yvette, France

    Michel B. Toledano

  4. Center for Molecular Oncology and Department of Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA

    Robert Wysocki

  5. Institute of Genetics and Microbiology, University of Wroclaw, 51-148 Wroclaw, Poland

    Robert Wysocki

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Tamás, M.J., Labarre, J., Toledano, M.B., Wysocki, R. (2005). Mechanisms of toxic metal tolerance in yeast. In: Tamas, M.J., Martinoia, E. (eds) Molecular Biology of Metal Homeostasis and Detoxification. Topics in Current Genetics, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_105

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