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Signalling Pathways Controlling Fatty Acid Desaturation

  • Chapter
Lipids in Health and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 49))

Abstract

Microorganisms, plants and animals regulate the synthesis of unsaturated fatty acids (UFAs) during changing environmental conditions as well as in response to nutrients. Unsaturation of fatty acid chains has important structural roles in cell membranes: a proper ratio of saturated to UFAs contributes to membrane fluidity. Alterations in this ratio have been implicated in various disease states including cardiovascular diseases, immune disorders, cancer and obesity. They are also the major components of triglycerides and intermediates in the synthesis of biologically active molecules such as eicosanoids, which mediates fever, inflammation and neurotransmission. UFAs homeostasis in many organisms is achieved by feedback regulation of fatty acid desaturases gene transcription. Here, we review recently discovered components and mechanisms of the regulatory machinery governing the transcription of fatty acid desaturases in bacteria, yeast and animals.

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Authors and Affiliations

  1. Departamento de Microbiologia ySuipacha 531, (S2002LRK), Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas, Rosario, Argentina

    Diego de Mendoza

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  1. María Cecilia Mansilla
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  2. Claudia E. Banchio
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  3. Diego de Mendoza
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  1. Biochemistry Department, King’s College London, 150 Stamford Street, London SE1 9NH, UK

    Peter J. Quinn

  2. State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China

    Xiaoyuan Wang

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Mansilla, M.C., Banchio, C.E., de Mendoza, D. (2008). Signalling Pathways Controlling Fatty Acid Desaturation. In: Quinn, P.J., Wang, X. (eds) Lipids in Health and Disease. Subcellular Biochemistry, vol 49. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8831-5_3

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