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Target Pattern Recognition by Complement Proteins of the Classical and Alternative Pathways

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Target Pattern Recognition in Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 653))

Abstract

The complement system is a major component of the innate defence of animals against invading microorganisms, and is also essential for the recognition and clearance of damaged or structurally-altered host cells or macromolecules. The system is activated by three different pathways, each of which responds, using different recognition molecules, to a very wide range of activators. The recognition protein of the complement classical pathway, C1q is described in detail here, with comparisons to the alternative pathway.

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Authors and Affiliations

  1. Department of Pharmacology, Oxford University, Mansfield Rd, Oxford, OX1 3QT, UK

    Robert B. Sim

  2. MRC Immunochemistry Unit Department of Pharmacology, University of Oxford, Oxford, UK

    Yu-Hoi Kang

  3. MRC Immunochemistry Unit Department of Biochemistry, University of Oxford, Oxford, UK

    Lee Aun Tan, Maria V. Carroll & Madeleine E. Gentle

  4. Division of Cell and Molecular Biology, Imperial College London, London, UK

    Lee Aun Tan & Madeleine E. Gentle

  5. Department of Pharmacology, University of Oxford, Oxford, UK

    Maria V. Carroll

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  1. Yu-Hoi Kang
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  2. Lee Aun Tan
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  3. Maria V. Carroll
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  4. Madeleine E. Gentle
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Editors and Affiliations

  1. Laboratory of Human Immunology and Infection Biology, Biosciences Division, School of Health Sciences and Social Care, Brunei University, Uxbridge, London, UK

    Uday Kishore PhD

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Kang, YH., Tan, L.A., Carroll, M.V., Gentle, M.E., Sim, R.B. (2009). Target Pattern Recognition by Complement Proteins of the Classical and Alternative Pathways. In: Kishore, U. (eds) Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology, vol 653. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0901-5_8

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