Skip to main content

2013 | OriginalPaper | Buchkapitel

7. Bio/CMOS Interfaces for Label-Free Capacitance Sensing

verfasst von : Sandro Carrara

Erschienen in: Bio/CMOS Interfaces and Co-Design

Verlag: Springer New York

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

We saw in Chap.​ 4 how singe-stranded DNA oligonucleotides hybridize to form double-stranded DNA; we also saw that antibodies and antigens interact to form immune complexes. In both cases, we can immobilize one of the two molecules of the complex (the probe) in our Bio/CMOS interface and obtain a surface that can detect the other molecule (the target) in a specific manner. We saw in Chap.​ 6 the electrical behavior of hybridization at an interface. We discussed that hybridization affects the equivalent capacitance of the Bio/CMOS interface. Chapter 6 also demonstrated the use of special molecules to improve the Bio/CMOS interface on the nanoscale. It was demonstrated that the improvement provides a more reliable interface for biosensing. The aim of this chapter is to address the “CMOS side” of the interface, in other words, to discuss some CMOS architectures that have been implemented to obtain biochips for label-free sensing of biomolecules.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Ghafar-Zadeh E, Sawan M (2010) Cmos capacitive sensors for lab-on-chip applications: a multidisciplinary approach. Springer, New YorkCrossRef Ghafar-Zadeh E, Sawan M (2010) Cmos capacitive sensors for lab-on-chip applications: a multidisciplinary approach. Springer, New YorkCrossRef
2.
Zurück zum Zitat Liu R, Lee AP (2010) Integrated biochips for DNA analysis, Springer, New York Liu R, Lee AP (2010) Integrated biochips for DNA analysis, Springer, New York
3.
Zurück zum Zitat Iniewski K (2008) VLSI circuits for biomedical applications. Artech House, Norwood Iniewski K (2008) VLSI circuits for biomedical applications. Artech House, Norwood
4.
Zurück zum Zitat Stagni C, Guiducci C, Benini L, Riccò B, Carrara S, Samorí B, Paulus C, Schienle M, Augustyniak M, Thewes R (2006) Cmos DNA sensor array with integrated A/D conversion based on label-free capacitance measurement. Ieee J Solid-State Circ 41(12):2956–2964CrossRef Stagni C, Guiducci C, Benini L, Riccò B, Carrara S, Samorí B, Paulus C, Schienle M, Augustyniak M, Thewes R (2006) Cmos DNA sensor array with integrated A/D conversion based on label-free capacitance measurement. Ieee J Solid-State Circ 41(12):2956–2964CrossRef
5.
Zurück zum Zitat Stagni C, Guiducci C, Benini L, Riccò B, Carrara S, Paulus C, Schienle M, Thewes R (2007) A fully electronic label-free DNA sensor chip. IEEE Sensor J 7(4):577–585CrossRef Stagni C, Guiducci C, Benini L, Riccò B, Carrara S, Paulus C, Schienle M, Thewes R (2007) A fully electronic label-free DNA sensor chip. IEEE Sensor J 7(4):577–585CrossRef
6.
Zurück zum Zitat De Venuto D, Carrara S, Ricco B (2009) Design of an integrated low-noise read-out system for DNA capacitive sensors. Microelectron J 40:1358–1365CrossRef De Venuto D, Carrara S, Ricco B (2009) Design of an integrated low-noise read-out system for DNA capacitive sensors. Microelectron J 40:1358–1365CrossRef
7.
Zurück zum Zitat Carrara S, Benini L, Bhalla V, Stagni C, Ferretti A, Cavallini A, Riccò B, Samorì B (2009) New insights for using self-assembly materials to improve the detection stability in label-free DNA-chip and immuno-sensors. Biosens Bioelectron 24:3425–3429CrossRef Carrara S, Benini L, Bhalla V, Stagni C, Ferretti A, Cavallini A, Riccò B, Samorì B (2009) New insights for using self-assembly materials to improve the detection stability in label-free DNA-chip and immuno-sensors. Biosens Bioelectron 24:3425–3429CrossRef
8.
Zurück zum Zitat Carrara S, Bhalla V, Stagni C, Benini L, Ferretti A, Valle F, Gallotta A, Riccò B, Samorì B (2009) Label-free cancer markers detection by capacitance biochip. Sensor Actuator B: Chem 136:163–172CrossRef Carrara S, Bhalla V, Stagni C, Benini L, Ferretti A, Valle F, Gallotta A, Riccò B, Samorì B (2009) Label-free cancer markers detection by capacitance biochip. Sensor Actuator B: Chem 136:163–172CrossRef
9.
Zurück zum Zitat Carminati M, Ferrari G, Guagliardo F, Sampietro M (2011) ZeptoFarad capacitance detection with a miniaturized CMOS current front-end for nanoscale sensors. Sensors Actuators A Phys 172:117–123 Carminati M, Ferrari G, Guagliardo F, Sampietro M (2011) ZeptoFarad capacitance detection with a miniaturized CMOS current front-end for nanoscale sensors. Sensors Actuators A Phys 172:117–123
10.
Zurück zum Zitat Tsouti V, Boutopoulos C, Zergioti I, Chatzandroulis S (2011) Capacitive microsystems for biological sensing (review). Biosensors Bioelect 27:1–11 Tsouti V, Boutopoulos C, Zergioti I, Chatzandroulis S (2011) Capacitive microsystems for biological sensing (review). Biosensors Bioelect 27:1–11
11.
Zurück zum Zitat Thewes R, Hofmann F, Frey A, Holzapfl B, Schienle M, Paulus C, Schindler P, Eckstein G, Kassel C, Stanzel M, Hintsche R, Nebling E, Albers J, Hassman J, Schülein J, Goemann W, Gumbrecht W (2002) Sensor arrays for fully-electronic DNA detection on CMOS. In: IEEE international conference on solid-state circuits, ISSCC 2002, San Francisco, pp 350–473 Thewes R, Hofmann F, Frey A, Holzapfl B, Schienle M, Paulus C, Schindler P, Eckstein G, Kassel C, Stanzel M, Hintsche R, Nebling E, Albers J, Hassman J, Schülein J, Goemann W, Gumbrecht W (2002) Sensor arrays for fully-electronic DNA detection on CMOS. In: IEEE international conference on solid-state circuits, ISSCC 2002, San Francisco, pp 350–473
Metadaten
Titel
Bio/CMOS Interfaces for Label-Free Capacitance Sensing
verfasst von
Sandro Carrara
Copyright-Jahr
2013
Verlag
Springer New York
DOI
https://doi.org/10.1007/978-1-4614-4690-3_7

Neuer Inhalt