Abstract
The laboratory and small pilot plant bioreactors of Chapter 8 are used to develop new processes and to improve our understanding of existing processes. These small-scale bioreactors can be assumed to be homogeneous with respect to substrate and metabolic product concentrations, and the mass balances are therefore rather simple. The industrial application of microorganisms does, however, involve bioreactors up to 1000 m3 in size, in which concentration gradients will inevitably exist. When the microorganisms are grown in these large bioreactors, they may therefore experience a continuously changing environment. The scale-up of a newly developed process from the laboratory to industry is therefore difficult. It may require a considerable research effort and may in some cases become a real bottleneck in the development of a new process.
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Nielsen, J., Villadsen, J. (1994). Bioreactor Modeling. In: Bioreaction Engineering Principles. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4645-7_9
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DOI: https://doi.org/10.1007/978-1-4757-4645-7_9
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