Abstract
The laboratory and small pilot plant bioreactors of Chapter 8 are used to develop new processes and to improve our understanding of existing processes. These small-scale bioreactors can be assumed to be homogeneous with respect to substrate and metabolic product concentrations, and the mass balances are therefore rather simple. The industrial application of microorganisms does, however, involve bioreactors up to 1000 m3 in size, in which concentration gradients will inevitably exist. When the microorganisms are grown in these large bioreactors, they may therefore experience a continuously changing environment. The scale-up of a newly developed process from the laboratory to industry is therefore difficult. It may require a considerable research effort and may in some cases become a real bottleneck in the development of a new process.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Balmer, G. J., Moore, I. P. T., and Nienow, A. W. (1987). “Aerated and unaerated poocr.m d ma.s transfer characteristics of Prochem agitators,” in Biotechnology ProcesAc.s: St tilt’ Ur du t t/rmorv. Ho, C. S. and Oldshue, J. Y., eds., AIChE, New York, 116–127.
Bird, R. B., Armstrong, R. C., and Hassager, O. (1987). Dynamics of Polymer’, Elm,lh. A„I I. livid Dynamics, John Wiley Sons, New York.
Bryant, J. (1977), J. (1977). “The characterization of mixing in fermenters,” Adv. Bioche’’’. l ow,. 5. 1001
Christensen, L. H. (1992). Modelling of the Penicillin Fermentation, Ph.D. thesis. 1 cchni.,l I nRcr.uc of Denmark, Lyngby, Denmark.
Crozier, D. B. A. (1990). “A detailed study of the flow characteristics in a tall stirred tank. l’i,s. 1_aser anemometry-3rd International Conference, Springer-Verlag, Berlin, 3593
Deckwer W.-D. (1992). Bubble Column Reactors, John Wiley Sons, Chichester_
Kossen, N. W. F. and Oosterhuis, N. M. G. (1985). “Modelling and scaling-up of bioreactors,” in Biotechnology 2nd edn., Rehm, H.-J. and Reed, G., eds., VCH-Verlag, Weinheim, Germany.
Levenspiel, O. (1972). “Chemical reaction engineering,” 2nd ed. John Wiley Sons, New York.
Joshi, J. B., Patil, T. A., Ranade, V. V., and Shah, Y. T. (1990). “Measurement of hydrodynamic parameters in multiphase sparged reactors,” Rev. Chem. Eng. 6, 74–227.
Mann, R., Mavros, P. P., and Middleton, J. C. (1981). “A structured stochastic flow model interpreting flow follower data from a stirred vessel,” Trans. Institution Chem. Engrs. 59, 271–278.
McDonough, R. J. (1992). Mixing for the Process Industries, Van Nostrand-Reinhold, New York.
Moser, A. (1988). Bioprocess Technology, Springer-Verlag, New York.
Nienow, A. W. (1990). “Agitators for mycelial fermentations,” Tibtech 8, 224–233.
Nienow, A. W. and Lilly, M. D. (1979). “Power drawn by multiple impellers in sparged vessels,” Biotechnol. Bioeng. 21, 2341–2345.
Nienow, A. W. and Elston, T. P. (1988). “Aspects of mixing in rheologically complex fluids,” Chem. Eng. Res. Des. 66, 5–15.
Oosterhuis, N. M. G. and Kossen, N. W. F. (1983). “Oxygen transfer in a production scale bioreactor,” Chem. Eng. Res. Des. 61, 308–312.
Pedersen, A. G. (1992). Characterization and Modelling of Bioreactors, Ph.D. thesis, Technical University of Denmark, Lyngby, Denmark.
Pedersen, A. G., Bundgârd, M., Nielsen, J., Villadsen, J., and Hassager, O. (1993). “Rheological characterization of media containing Penicillium chrysogenum, ” Biotechnol. Bioeng. 41, 162–164.
Peters, H.-U., Herbst, H., Hesselink, P. G. M., Lünsdorf, H., Schumpe, A., and Deckwer, W.-D. (1989). “The influence of agitation rate on xanthan production by Xanthomonas campestris, ” Biotechnol. Bioeng. 34, 1393–1397.
Ranade, V. V. and Joshi, J. B. (1989). “Flow generated by pitched blade turbines: I. Measurements using laser doppler anemometer,” Chem. Eng. Commun. 81, 197–224.
Roels, J. A., van den Berg, J., and Voncken, R. M. (1974). “The rheology of mycelial broths,” Biotechnol. Bioeng. 16, 181–208.
Schügerl, K. (1981). “Oxygen transfer into highly viscous media,” Adv. Biochem. Eng. 19, 71–174.
Schügerl, K. (1991). Bioreaction Engineering, Vol. 2, John Wiley Sons, Chichester, U.K.
Schügerl, K., Lücke, J., and Oels, U. (1977). “Bubble column bioreactors,” Adv. Biochem. Eng. 7, 1–84.
Suh, 1.-S., Schumpe, A., Deckwer, W.-D., and Kulicke, W.-M. (1991). “Gas-liquid mass transfer in the bubble column with viscoelastic liquid,” Can. J. Chem. Eng. 69, 506–512.
Sweere, A. P. J., Luyben, K. Ch. A. M., and Kossen, N. W. F. (1987). “Regime analysis and scaledown: tools to investigate the performance of bioreactors,” Enz. Microb. Technol. 9, 386–398.
Sweere, A. P. J., Mesters, J. R., Janse, L., Luyben, K. Ch. A. M., and Kossen, N. W. F. (1988a). “Experimental simulation of oxygen profiles and their influence on bakers yeast production: I. Onefermentor system,” Biotechnol. Bioeng. 31, 567–578.
Sweere, A. P. J., Janse, L., Luyben, K. Ch. A. M., and Kossen, N. W. F. (1988b). “Experimental simulation of oxygen profiles and their influence on bakers yeast production: II. Two-fermentor system,” Biotechnol. Bioeng. 31, 579–586.
Vashitz, O. and Sheintuch, M. (1991). “Analysis of polymer synthesis rates during steady state growth of X. campestris, ” Biotechnol. Bioeng. 37, 383–385.
van de Vusse, J. G. (1962). “A new model for the stirred tank reactor, Chem. Eng. Sci. 17, 507–521.
Westerterp, K. R., van Swaaij, W. P. M., and Beenackers, A. C. M. (1984). Chemical Reactor Design and Operation, J. Wiley Sons, New York.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Nielsen, J., Villadsen, J. (1994). Bioreactor Modeling. In: Bioreaction Engineering Principles. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4645-7_9
Download citation
DOI: https://doi.org/10.1007/978-1-4757-4645-7_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-4647-1
Online ISBN: 978-1-4757-4645-7
eBook Packages: Springer Book Archive