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Structural and Vascular Analysis of Tissue Engineering Scaffolds, Part 2: Topology Optimisation

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Book cover Computer-Aided Tissue Engineering

Part of the book series: Methods in Molecular Biology ((MIMB,volume 868))

Abstract

Rapid prototyping technologies were recently introduced in the medical field, being particularly viable to produce porous scaffolds for tissue engineering. These scaffolds should be biocompatible, biodegradable, with appropriate porosity, pore structure, and pore distribution, on top of presenting both surface and structural compatibility. Surface compatibility means a chemical, biological, and physical suitability with the host tissue. Structural compatibility corresponds to an optimal adaptation to the mechanical behaviour of the host tissue. This chapter presents a computer tool to support the design of scaffolds to be produced by rapid prototyping technologies. The software enables to evaluate scaffold mechanical properties as a function of porosity and pore topology and distribution, for a wide rage of materials, suitable for both hard and soft tissue engineering.

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Acknowledgements

This research is supported by the Portuguese Foundation of Science and Technology through a Ph.D. grant of Henrique Almeida (SFRH/BD/37604/2007). The authors also wish to thank the sponsorship given by CYTED through a Biomanufacturing Network “Rede Iberoamericana de Biofabricação.”

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Authors and Affiliations

  1. Department of Mechanical Engineering, Institute for Polymers and Composites, School of Technology and Management, Polytechnic Institute of Leiria, Leiria, Portugal

    Henrique A. Almeida

  2. Centre for Rapid and Sustainable Product Development, Department of Mechanical Engineering, Institute for Polymers and Composites, School of Technology and Management, Polytechnic Institute of Leiria, Leiria, Portugal

    Paulo J. Bártolo

Authors
  1. Henrique A. Almeida
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  2. Paulo J. Bártolo
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Corresponding author

Correspondence to Paulo J. Bártolo .

Editor information

Editors and Affiliations

  1. , Department of Neurosurgery, Baylor College of Medicine, Holcombe Blvd. 2002, Houston, 77030, Texas, USA

    Michael A.K. Liebschner

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Almeida, H.A., Bártolo, P.J. (2012). Structural and Vascular Analysis of Tissue Engineering Scaffolds, Part 2: Topology Optimisation. In: Liebschner, M. (eds) Computer-Aided Tissue Engineering. Methods in Molecular Biology, vol 868. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-764-4_13

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  • DOI: https://doi.org/10.1007/978-1-61779-764-4_13

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-763-7

  • Online ISBN: 978-1-61779-764-4

  • eBook Packages: Springer Protocols

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