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2016 | OriginalPaper | Buchkapitel

10. Ceramic-Polymer Composites for Biomedical Applications

verfasst von : Toshiki Miyazaki, Masakazu Kawashita, Chikara Ohtsuki

Erschienen in: Handbook of Bioceramics and Biocomposites

Verlag: Springer International Publishing

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Abstract

Several kinds of ceramics exhibit direct bone bonding through formation of biologically active hydroxyapatite layer after implantation in bony defects. They are called bioactive ceramics and play an important role in clinical applications. However, there are still some drawbacks on clinical applications because conventional bioactive ceramics essentially have lower fracture toughness and higher Young’s modulus than natural bone. The bone takes an organic–inorganic composite where apatite nanocrystals are precipitated on collagen fibers. Therefore, problems on mechanical properties of the bioactive ceramics can be solved by designed composites composed of constituents driving bone-bonding capability. In this chapter, current research topics on development of the various organic–inorganic composites designed for biomedical application have been reviewed. Mechanical mixing of bioactive fillers in organic polymer matrix is a typical processing for fabrication of bioactive composites. In addition, coating in aqueous conditions is an important process for fabricating bioactive composites since their surface property and interaction with surrounding body fluid and tissues govern the biological activity of the materials. Functions of drug delivery, diagnosis, and treatment of cancer can be provided through material design based on organic–inorganic composites.

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Vorheriges Kapitel Natural and Synthetic Polymers for Designing Composite Materials

Nächstes Kapitel Collagen–Bioceramic Smart Composites

Hench LL, Wilson J (1993) Introduction. In: Hench LL, Wilson J (eds) An introduction to bioceramics. World Scientific, Singapore, pp 1–24CrossRef

Hench LL, Splinger RJ, Allen WC, Greenlee TK (1972) Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res Symp 2:117–141. doi:10.1002/jbm.820050611

Hench LL (1991) Bioceramics; from concept to clinic. J Am Ceram Soc 74:1487–1510. doi:10.1111/j.1151-2916.1991.tb07132.xCrossRef

Jarcho M, Bolen CH, Thomas MB, Bobick J, Kay JF, Doremus RH (1976) Hydroxyapatite synthesis and characterization in dense polycrystalline forms. J Mater Sci 11:2027–2035. doi:10.1007/BF02403350CrossRef

Kokubo T, Kim HM, Kawashita M (2003) Novel bioactive materials with different mechanical properties. Biomaterials 24:2161–2175. doi:10.1016/S0142-9612(03)00044-9CrossRef

Park JB, Lakes RS (1992) Biomaterials, an introduction, 2nd edn. Plenum Press, New YorkCrossRef

Neo M, Kotani S, Fujita Y, Nakamura T, Yamamuro T, Bando Y, Ohtsuki C, Kokubo T (1992) Differences in ceramic-bone interface between surface-active ceramics and resorbable ceramics: a study by scanning and transmission electron microscopy. J Biomed Mater Res 26:255–267. doi:10.1002/jbm.820260210CrossRef

Cho SB, Nakanishi K, Kokubo T, Soga N, Ohtsuki C, Nakamura T, Kitsugi T, Yamamuro T (1995) Dependence of apatite formation on silica gel on its structure: effect of heat treatment. J Am Ceram Soc 78:1769–1774. doi:10.1111/j.1151-2916.1995.tb08887.xCrossRef

Kokubo T, Takadama H (2006) How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27:2907–2915. doi:10.1016/j.biomaterials.2006.01.017CrossRef

10.

Oyane A, Kim HM, Furuya T, Kokubo T, Miyazaki T, Nakamura T (2003) Preparation and assessment of revised simulated body fluid. J Biomed Mater Res 65A:188–195. doi:10.1002/jbm.a.10482CrossRef

11.

Li P, Ohtsuki C, Kokubo T, Nakanishi K, Soga N, de Groot K (1994) The role of hydrated silica, titania and alumina in inducing apatite on implants. J Biomed Mater Res 28:7–15. doi:10.1002/jbm.820280103CrossRef

12.

Uchida M, Kim HM, Kokubo T, Fujibayashi S, Nakamura T (2003) Structural dependence of apatite formation on titania gels in a simulated body fluid. J Biomed Mater Res A 64:164–170. doi:10.1002/jbm.a.10414CrossRef

13.

Uchida M, Kim HM, Kokubo T, Miyaji F, Nakamura T (2001) Bonelike apatite formation induced on zirconia gel in a simulated body fluid and its modified solutions. J Am Ceram Soc 84:2041–2044. doi:10.1111/j.1151-2916.2001.tb00955.xCrossRef

14.

Miyazaki T, Kim HM, Miyaji F, Kokubo T, Nakamura T (2000) Bioactive tantalum metal prepared by NaOH treatment. J Biomed Mater Res 50:35–42. doi:10.1002/(SICI)1097-4636(200004)50:1<35::AID-JBM6>3.0.CO;2-8CrossRef

15.

Miyazaki T, Kim HM, Kokubo T, Kato H, Nakamura T (2001) Induction and acceleration of bonelike apatite formation on tantalum oxide gel in simulated body fluid. J Sol-Gel Sci Technol 21:83–88. doi:10.1023/A:1011265701447CrossRef

16.

Miyazaki T, Kim HM, Kokubo T, Ohtsuki C, Nakamura T (2001) Bonelike apatite formation induced on niobium oxide gels in simulated body fluid. J Ceram Soc Jpn 109:934–938. doi:10.2109/jcersj.109.1275_929CrossRef

17.

Tanahashi M, Matsuda T (1997) Surface functional group dependence on apatite formation on self-assembled monolayers in a simulated body fluid. J Biomed Mater Res 34:305–315. doi:10.1002/(SICI)1097-4636(19970305)34:33.0.CO;2-OCrossRef

18.

Kawai T, Ohtsuki C, Kamitakahara M, Miyazaki T, Tanihara M, Sakaguchi Y, Konagaya S (2004) Coating of apatite layer on polyamide films containing sulfonic groups by biomimetic process. Biomaterials 25:4529–4534. doi:10.1016/j.biomaterials.2003.11.039CrossRef

19.

Miyazaki T, Imamura M, Ishida E, Ashizuka M, Ohtsuki C (2009) Apatite formation abilities and mechanical properties of hydroxyethylmethacrylate-based organic-inorganic hybrids incorporated with sulfonic groups and calcium ions. J Mater Sci Mater Med 20:157–161. doi:10.1007/s10856-008-3556-5CrossRef

20.

Ohtsuki C, Kokubo T, Yamamuro T (1992) Mechanism of apatite formation on CaO-SiO₂-P₂O₅ glasses in a simulated body fluid. J Non-Cryst Solids 143:84–92. doi:10.1016/S0022-3093(05)80556-3CrossRef

21.

Sugino A, Tsuru K, Hayakawa S, Kikuta K, Kawachi G, Osaka A, Ohtsuki C (2009) Induced deposition of bone-like hydroxyapatite on thermally oxidized titanium substrates using a spatial gap in a solution that mimics a body fluid. J Ceram Soc Jpn 117:515–520. doi:10.2109/jcersj2.117.515CrossRef

22.

Shikinami Y, Okuno M (1999) Bioresorbable devices made of forged composites of hydroxyapatite and poly l-lactide (PLLA): part I. basic characteristics. Biomaterials 20:859–877. doi:10.1016/S0142-9612(98)00241-5CrossRef

23.

Bonfield W (1993) Design of bioactive ceramic-polymer composites. In: Hench LL, Wilson J (eds) An introduction to bioceramics. World Scientific, Singapore, pp 299–303CrossRef

24.

Kikuchi M, Itoh S, Ichinose S, Shinomiya K, Tanaka J (2001) Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials 22:1705–1711. doi:10.1016/S0142-9612(00)00305-7CrossRef

25.

Kawai T, Matsui K, Iibuchi S, Anada T, Honda Y, Sasaki K, Kamakura S, Suzuki O, Echigo S (2011) Reconstruction of critical-sized bone defect in dog skull by octacalcium phosphate combined with collagen. Clin Oral Implants Res 13:112–123. doi:10.1111/j.1708-8208.2009.00192.x

26.

Muramatsu K, Oba K, Mukai D, Hasegawa K, Masuda S, Yoshihara Y (2007) Subacute systemic toxicity assessment of β-tricalcium phosphate/carboxymethyl-chitin composite implanted in rat femur. J Mater Sci Mater Med 18:513–522. doi:10.1007/s10856-007-2012-2CrossRef

27.

Yoshida A, Miyazaki T, Ishida E, Ashizuka M (2006) Bioactivity and mechanical properties of cellulose/carbonate hydroxyapatite composites prepared in situ through mechanochemical reaction. J Biomater Appl 21:179–194. doi:10.1177/0885328206059796CrossRef

28.

Ma R, Tang T (2014) Current strategies to improve the bioactivity of PEEK. Int J Mol Sci 15:5426–5445. doi:10.3390/ijms15045426CrossRef

29.

Kim IY, Sugino A, Kikuta K, Ohtsuki C, Cho SB (2009) Bioactive composites consisting of PEEK and calcium silicate powders. J Biomater Appl 24:105–118. doi:10.1177/0885328208094557CrossRef

30.

Nakahara I, Takao M, Goto T, Ohtsuki C, Hibino S, Sugano N (2012) Interfacial shear strength of bioactive-coated carbon fiber reinforced polyetheretherketone after in vivo implantation. J Orthop Res 30:1618–1625. doi:10.1002/jor.22115CrossRef

31.

Ishikawa K, Miyamoto Y, Kon M, Nagayama M, Asaoka K (1995) Non-decay type fast-setting calcium phosphate cement: composite with sodium alginate. Biomaterials 16:527–532. doi:10.1016/0142-9612(95)91125-ICrossRef

32.

Makinen TJ, Veiranto M, Lankinen P, Moritz N, Jalava J, Tormala P, Aro HT (2005) In vitro and in vivo release of ciprofloxacin from osteoconductive bone defect filler. J Antimicrob Chemother 56:1063–1068. doi:10.1093/jac/dki366CrossRef

33.

Schnieders J, Gbureck U, Thull R, Kissel T (2006) Controlled release of gentamicin from calcium phosphate-poly(lactic acid-co-glycolic acid) composite bone cement. Biomaterials 27:4239–4249. doi:10.1016/j.biomaterials.2006.03.032CrossRef

34.

Otsuka M, Nakagawa H, Ito A, Higuchi WI (2010) Effect of geometrical structure on drug release rate of a three-dimensionally perforated porous apatite/collagen composite cement. J Pharm Sci 99:286–292. doi:10.1002/jps.21835CrossRef

35.

Lee YM, Park YJ, Lee SJ, Ku Y, Han SB, Klokkevold PR, Chung CP (2000) The bone regenerative effect of platelet-derived growth factor-BB delivered with a chitosan/tricalcium phosphate sponge carrier. J Periodontol 71:418–424. doi:10.1902/jop.2000.71.3.418CrossRef

36.

Zhang Y, Zhang M (2002) Calcium phosphate/chitosan composite scaffolds for controlled in vitro antibiotic drug release. J Biomed Mater Res 62:378–386. doi:10.1002/jbm.10312CrossRef

37.

Takahashi Y, Yamamoto M, Tabata Y (2005) Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and β-tricalcium phosphate. Biomaterials 26:4856–4865. doi:10.1016/j.biomaterials.2005.01.012CrossRef

38.

Leeuwenburgh S, Jo J, Wang H, Yamamoto M, Jansen JA, Tabata Y (2010) Mineralization, biodegradation, and drug release behavior of gelatin/apatite composite microspheres for bone regeneration. Biomacromolecules 11:2653–2659. doi:10.1021/bm1006344CrossRef

39.

Liu X, Okada M, Maeda H, Fujii S, Furuzono T (2011) Hydroxyapatite/biodegradable poly-(l-lactide-co-caprolactone) composite microparticles as injectable scaffold by a Pickering emulsion route. Acta Biomater 7:821–828. doi:10.1016/j.actbio.2010.08.023CrossRef

40.

Mima Y, Fukumoto S, Koyama H, Okada M, Tanaka S, Shoji T, Emoto M, Furuzono T, Nishizawa Y, Inaba M (2012) Enhancement of cell-based therapeutic angiogenesis using a novel type of injectable scaffolds of hydroxyapatite-polymer nanocomposite microspheres. PLoS One 7:e35199. doi:10.1371/journal.pone.0035199CrossRef

41.

Kühn KD (2000) Bone cements. Springer, BerlinCrossRef

42.

Dalby MJ, Di Silvio L, Harper EJ, Bonfield W (1999) In vitro evaluation of a new polymethylmethacrylate cement reinforced with hydroxyapatite. J Mater Sci Mater Med 10:793–796. doi:10.1023/A:1008907218330CrossRef

43.

Shinzato S, Kobayashi M, Mousa WF, Kamimura M, Neo M, Kitamura Y, Kokubo T, Nakamura T (2000) Bioactive polymethyl methacrylate-based bone cement: comparison of glass beads, apatite- and wollastonite-containing glass-ceramic, and hydroxyapatite fillers on mechanical and biological properties. J Biomed Mater Res 51:258–272. doi:10.1002/(SICI)1097-4636(200008)51:2<258::AID-JBM15>3.0.CO;2-SCrossRef

44.

Goto K, Tamura J, Shinzato S, Fujibayashi S, Hashimoto M, Kawashita M, Kokubo T, Nakamura T (2005) Bioactive bone cements containing nano-sized titania particles for use as bone substitutes. Biomaterials 26:6496–6505. doi:10.1016/j.biomaterials.2005.04.044CrossRef

45.

Miyazaki T, Ohtsuki C, Kyomoto M, Tanihara M, Mori A, Kuramoto K (2003) Bioactive PMMA bone cement prepared by modification with methacryloxypropyltrimethoxysilane and calcium chloride. J Biomed Mater Res 67A:1417–1423. doi:10.1002/jbm.a.20042CrossRef

46.

Sugino A, Ohtsuki C, Miyazaki T (2008) In vivo response of bioactive PMMA-based bone cement modified with alkoxysilane and calcium acetate. J Biomater Appl 23:213–228. doi:10.1177/0885328207081694CrossRef

47.

Kasuga T, Maeda H, Kato K, Nogami M, Hata K, Ueda M (2003) Preparation of poly(lactic acid) composites containing calcium carbonate (vaterite). Biomaterials 24:3247–3253. doi:10.1016/S0142-9612(03)00190-XCrossRef

48.

Obata A, Hotta T, Wakita T, Ota Y, Kasuga T (2010) Electrospun microfiber meshes of silicon-doped vaterite/poly(lactic acid) hybrid for guided bone regeneration. Acta Biomater 6:1248–1257. doi:10.1016/j.actbio.2009.11.013CrossRef

49.

Ozawa N, Yao T (2002) Micropattern formation of apatite by combination of a biomimetic process and transcription of resist pattern. J Biomed Mater Res 62:579–586. doi:10.1002/jbm.10281CrossRef

50.

Hata K, Kokubo T, Nakamura T, Yamamuro T (1995) Growth of bonelike apatite layer on a substrate by a biomimetic process. J Am Ceram Soc 78:1049–1053. doi:10.1111/j.1151-2916.1995.tb08435.xCrossRef

51.

Habibovic P, Barrere F, van Blitterswijk CA, de Groot K, Layrolle P (2002) Biomimetic hydroxyapatite coating on metal implants. J Am Ceram Soc 517–522. doi:10.1111/j.1151-2916.2002.tb00126.x

52.

Kawashita M, Nakao M, Minoda M, Kim HM, Beppu T, Miyamoto T, Kokubo T, Nakamura T (2003) Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid. Biomaterials 24:2477–2484. doi:10.1016/S0142-9612(03)00050-4CrossRef

53.

Miyazaki T, Ohtsuki C, Akioka Y, Tanihara M, Nakao J, Sakaguchi Y, Konagaya S (2003) Apatite deposition on polyamide films containing carboxyl group in a biomimetic solution. J Mater Sci Mater Med 569–574. doi:10.1023/A:1024000821368

54.

Miyazaki T, Ishikawa K, Shirosaki Y, Ohtsuki C (2013) Organic-inorganic composites designed for biomedical applications. Biol Pharm Bull 36:1670–1675. doi:10.1248/bpb.b13-00424CrossRef

55.

Ichibouji T, Miyazaki T, Ishida E, Ashizuka M, Sugino A, Ohtsuki C, Kuramoto K (2008) Evaluation of apatite-forming ability and mechanical property of pectin hydrogels. J Ceram Soc Jpn 116:74–78. doi:10.2109/jcersj2.116.74CrossRef

56.

Ichibouji T, Miyazaki T, Ishida E, Sugino A, Ohtsuki C (2009) Apatite mineralization abilities and mechanical properties of covalently cross-linked pectin hydrogels. Mater Sci Eng C 29:1765–1769. doi:10.1016/j.msec.2009.01.027CrossRef

57.

Bonfield W (1996) Composite biomaterials. In: Kokubo T, Nakamura T, Miyaji F (eds) Bioceramics, vol 9. Elsevier, Oxford, pp 11–13

58.

Chen Q, Miyata N, Kokubo T, Nakamura T (2000) Bioactivity and mechanical properties of PDMS-modified CaO–SiO₂–TiO₂ hybrids prepared by sol-gel process. J Biomed Mater Res 51:605–611. doi:10.1002/1097-4636(20000915)51:4<605::AID-JBM8>3.0.CO;2-UCrossRef

59.

Miyazaki T, Yasunaga S, Ishida E, Ashizuka M, Ohtsuki C (2007) Effects of cross-linking agent on apatite-forming ability and mechanical property of organic-inorganic hybrids based on starch. Mater Trans 48:317–321. doi:10.2320/matertrans.48.317CrossRef

60.

Kawashita M, Tanaka M, Kokubo T, Inoue Y, Yao T, Hamada S, Shinjo T (2005) Preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer. Biomaterials 26:2231–2238. doi:10.1016/j.biomaterials.2004.07.014CrossRef

61.

Zhao J, Sekikawa H, Kawai T, Unuma H (2009) Ferrimagnetic magnetite hollow microspheres prepared via enzimatically precipitated iron hydroxide on a urease-bearing polymer template. J Ceram Soc Jpn 117:344–346. doi:10.2109/jcersj2.117.344CrossRef

62.

Miyazaki T, Miyaoka A, Ishida E, Li Z, Kawashita M, Hiraoka M (2012) Preparation of ferromagnetic microcapsules for hyperthermia using water/oil emulsion as a reaction field. Mater Sci Eng C 32:692–696. doi:10.1016/j.msec.2012.01.010CrossRef

63.

Mitsumori M, Hiraoka M, Shibata T, Okuno Y, Masunaga S, Koishi M, Okajima K, Nagata Y, Nishimura Y, Abe M, Ohura K, Hasegawa M, Nagae H, Ebisawa Y (1994) Development of intra-arterial hyperthermia using a dextran-magnetite complex. Int J Hyperth 10:785–793. doi:10.3109/02656739409012371CrossRef

64.

Minamimura T, Sato H, Kasaoka S, Saito T, Ishizawa S, Takemori S, Tazawa K, Tsukada K (2000) Tumor regression by inductive hyperthermia combined with hepatic embolization using dextran magnetite-incorporated microspheres in rats. Int J Oncol 16:1153–1158. doi:10.3892/ijo.16.6.1153

65.

Miyazaki T, Anan S, Ishida E, Kawashita M (2013) Carboxymethyldextran/magnetite hybrid microspheres designed for hyperthermia. J Mater Sci Mater Med 24:1125–1129. doi:10.1007/s10856-013-4874-9CrossRef

66.

Matsumine A, Kusuzaki K, Matsubara T, Shintani K, Satonaka H, Wakabayashi T, Miyazaki S, Morita K, Takegami K, Uchida A (2007) Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field. Clin Exp Metastasis 24:191–200. doi:10.1007/s10585-007-9068-8CrossRef

67.

Kawashita M, Kawamura K, Li Z (2010) PMMA-based bone cements containing magnetite particles for the hyperthermia of cancer. Acta Biomater 6:3187–3192. doi:10.1016/j.actbio.2010.02.047CrossRef

68.

Li Z, Kawamura K, Kawashita M, Kudo T, Kanetaka H, Hiraoka M (2012) In vitro heating capability, mechanical strength and biocompatibility assessment of PMMA-based bone cement containing magnetite nanoparticles for hyperthermia of cancer. J Biomed Mater Res 100A:2537–2545. doi:10.1002/jbm.a.34185CrossRef

69.

Kuwahara Y, Miyazaki T, Shirosaki Y, Kawashita M (2014) Effects of organic polymer addition in magnetite synthesis on its crystalline structure. RSC Adv 4:23359–23363. doi:10.1039/C4RA02073ACrossRef

70.

Hayashi K, Moriya M, Sakamoto W, Yogo T (2009) Chemoselective synthesis of folic acid – functionalized magnetite nanoparticles via click chemistry for magnetic hyperthermia. Chem Mater 21:1318–1325. doi:10.1021/cm803113eCrossRef

71.

Shinkai M, Yanase M, Honda H, Wakabayashi T, Yoshida J, Kobayashi T (1996) Intracellular hyperthermia for cancer using magnetite cationic liposomes: in vitro study. Jpn J Cancer Res 87:1179–1183. doi:10.1111/j.1349-7006.1996.tb03129.xCrossRef

72.

Ito A, Hibino E, Kobayashi C, Terasaki H, Kagami H, Ueda M, Kobayashi T, Honda H (2005) Construction and delivery of tissue-engineered human retinal pigment epithelial cell sheets, using magnetite nanoparticles and magnetic force. Tissue Eng 11:489–496. doi:10.1089/ten.2005.11.489CrossRef

73.

Erbe EM, Day DE (1987) Chemical durability of Y₂O₃-Al₂O₃-SiO₂ glasses for the in vivo delivery of beta radiation. J Biomed Mater Res 27:1301–1308. doi:10.1002/jbm.820271010CrossRef

74.

Kawashita M, Takayama Y, Kokubo T, Takaoka GH, Araki N, Hiraoka M (2006) Enzymatic preparation of hollow yttrium oxide microspheres for in situ radiotherapy of deep-seated cancer. J Am Ceram Soc 89:1347–1351. doi:10.1111/j.1551-2916.2005.00867.xCrossRef

75.

Miyazaki T, Kai T, Ishida E, Kawashita M, Hiraoka M (2010) Fabrication of yttria microcapsules for radiotherapy from water/oil emulsion. J Ceram Soc Jpn 118:479–482. doi:10.2109/jcersj2.118.479CrossRef

76.

Kawashita M, Matsui N, Li Z, Miyazaki T, Kanetaka H (2011) Preparation, structure, and in vitro chemical durability of yttrium phosphate microspheres for intra-arterial radiotherapy. J Biomed Mater Res B Appl Biomater 99:45–50. doi:10.1002/jbm.b.31870CrossRef

77.

Miyazaki T, Suda T, Shirosaki Y, Kawashita M (2014) Fabrication of yttrium phosphate microcapsules by an emulsion route for in situ cancer radiotherapy. J Med Biol Eng 34:14–17. doi:10.5405/jmbe.1451CrossRef

78.

Schubiger PA, Beer HF, Geiger L, Rösler H, Zimmermann A, Triller J, Mettler D, Schilt W (1991) ⁹⁰Y-resin particles – animal experiments on pigs with regard to the introduction of superselective embolization therapy. Int J Rad Appl Instrum B 18:305–311. doi:10.1016/0883-2897(91)90126-6CrossRef

79.

Venkatachalam N, Saito Y, Soga K (2009) Synthesis of Er³⁺ doped Y₂O₃ nanophosphors. J Am Ceram Soc 92:1006–1010. doi:10.1111/j.1551-2916.2009.02986.xCrossRef

80.

Uo M, Kudo E, Okada A, Soga K, Kogo Y (2009) Preparation and properties of dental composite resin cured under near infrared irradiation. J Photopolym Sci Technol 22:551–554. doi:10.2494/photopolymer.22.551CrossRef

Titel: Ceramic-Polymer Composites for Biomedical Applications
verfasst von: Toshiki Miyazaki
Masakazu Kawashita
Chikara Ohtsuki
Verlag: Springer International Publishing
Buch: Handbook of Bioceramics and Biocomposites
Print ISBN: 978-3-319-12459-9

Electronic ISBN: 978-3-319-12460-5

Copyright-Jahr: 2016
DOI: https://doi.org/10.1007/978-3-319-12460-5_16

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