Skip to main content

2016 | OriginalPaper | Buchkapitel

Discrete Abstraction of Multiaffine Systems

verfasst von : Hui Kong, Ezio Bartocci, Sergiy Bogomolov, Radu Grosu, Thomas A. Henzinger, Yu Jiang, Christian Schilling

Erschienen in: Hybrid Systems Biology

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Many biological systems can be modeled as multiaffine hybrid systems. Due to the nonlinearity of multiaffine systems, it is difficult to verify their properties of interest directly. A common strategy to tackle this problem is to construct and analyze a discrete overapproximation of the original system. However, the conservativeness of a discrete abstraction significantly determines the level of confidence we can have in the properties of the original system. In this paper, in order to reduce the conservativeness of a discrete abstraction, we propose a new method based on a sufficient and necessary decision condition for computing discrete transitions between states in the abstract system. We assume the state space partition of a multiaffine system to be based on a set of multivariate polynomials. Hence, a rectangular partition defined in terms of polynomials of the form \((x_i-c)\) is just a simple case of multivariate polynomial partition, and the new decision condition applies naturally. We analyze and demonstrate the improvement of our method over the existing methods using some examples.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Alur, R., Dang, T., Ivančić, F.: Progress on reachability analysis of hybrid systems using predicate abstraction. In: Maler, O., Pnueli, A. (eds.) HSCC 2003. LNCS, vol. 2623, pp. 4–19. Springer, Heidelberg (2003)CrossRef Alur, R., Dang, T., Ivančić, F.: Progress on reachability analysis of hybrid systems using predicate abstraction. In: Maler, O., Pnueli, A. (eds.) HSCC 2003. LNCS, vol. 2623, pp. 4–19. Springer, Heidelberg (2003)CrossRef
2.
Zurück zum Zitat Asarin, E., Dang, T., Girard, A.: Reachability analysis of nonlinear systems using conservative approximation. In: Maler, O., Pnueli, A. (eds.) HSCC 2003. LNCS, vol. 2623, pp. 20–35. Springer, Heidelberg (2003)CrossRef Asarin, E., Dang, T., Girard, A.: Reachability analysis of nonlinear systems using conservative approximation. In: Maler, O., Pnueli, A. (eds.) HSCC 2003. LNCS, vol. 2623, pp. 20–35. Springer, Heidelberg (2003)CrossRef
3.
Zurück zum Zitat Bak, S., Bogomolov, S., Henzinger, T.A., Johnson, T.T., Prakash, P.: Scalable static hybridization methods for analysis of nonlinear systems. In: Proceedings of the 19th International Conference on Hybrid Systems: Computation and Control, HSCC 2016, Vienna, Austria, pp. 155–164, 12–14 April 2016 Bak, S., Bogomolov, S., Henzinger, T.A., Johnson, T.T., Prakash, P.: Scalable static hybridization methods for analysis of nonlinear systems. In: Proceedings of the 19th International Conference on Hybrid Systems: Computation and Control, HSCC 2016, Vienna, Austria, pp. 155–164, 12–14 April 2016
4.
Zurück zum Zitat Bartocci, E., Corradini, F., Di Berardini, M.R., Entcheva, E., Smolka, S.A., Grosu, R.: Modeling and simulation of cardiac tissue using hybrid I/O automata. Theor. Comput. Sci. 410(33), 3149–3165 (2009)MathSciNetCrossRefMATH Bartocci, E., Corradini, F., Di Berardini, M.R., Entcheva, E., Smolka, S.A., Grosu, R.: Modeling and simulation of cardiac tissue using hybrid I/O automata. Theor. Comput. Sci. 410(33), 3149–3165 (2009)MathSciNetCrossRefMATH
5.
Zurück zum Zitat Bartocci, E., Corradini, F., Entcheva, E., Grosu, R., Smolka, S.A.: Cellexcite: an efficient simulation environment for excitable cells. BMC Bioinform. 9, S–2 (2008)CrossRef Bartocci, E., Corradini, F., Entcheva, E., Grosu, R., Smolka, S.A.: Cellexcite: an efficient simulation environment for excitable cells. BMC Bioinform. 9, S–2 (2008)CrossRef
6.
Zurück zum Zitat Bartocci, E., Lió, P.: Computational modeling, formal analysis and tools for systems biology. PLOS Comput. Biol. 12(1), e1004591 (2016)CrossRef Bartocci, E., Lió, P.: Computational modeling, formal analysis and tools for systems biology. PLOS Comput. Biol. 12(1), e1004591 (2016)CrossRef
7.
Zurück zum Zitat Bartocci, E., Liò, P., Merelli, E., Paoletti, N.: Multiple verification in complex biological systems: the bone remodelling case study. Trans. Comput. Syst. Biol. 14, 53–76 (2012)CrossRefMATH Bartocci, E., Liò, P., Merelli, E., Paoletti, N.: Multiple verification in complex biological systems: the bone remodelling case study. Trans. Comput. Syst. Biol. 14, 53–76 (2012)CrossRefMATH
8.
Zurück zum Zitat Batt, G., Belta, C., Weiss, R.: Temporal logic analysis of gene networks under parameter uncertainty. Trans. Autom. Control 53(Special Issue), 215–229 (2008)MathSciNetCrossRef Batt, G., Belta, C., Weiss, R.: Temporal logic analysis of gene networks under parameter uncertainty. Trans. Autom. Control 53(Special Issue), 215–229 (2008)MathSciNetCrossRef
9.
Zurück zum Zitat Batt, G., De Jong, H., Page, M., Geiselmann, J.: Symbolic reachability analysis of genetic regulatory networks using discrete abstractions. Automatica 44(4), 982–989 (2008)MathSciNetCrossRefMATH Batt, G., De Jong, H., Page, M., Geiselmann, J.: Symbolic reachability analysis of genetic regulatory networks using discrete abstractions. Automatica 44(4), 982–989 (2008)MathSciNetCrossRefMATH
10.
Zurück zum Zitat Belta, C., Habets, L.C.: Controlling a class of nonlinear systems on rectangles. Trans. Autom. Control 51(11), 1749–1759 (2006)MathSciNetCrossRef Belta, C., Habets, L.C.: Controlling a class of nonlinear systems on rectangles. Trans. Autom. Control 51(11), 1749–1759 (2006)MathSciNetCrossRef
11.
Zurück zum Zitat Bogomolov, S., Donzé, A., Frehse, G., Grosu, R., Johnson, T.T., Ladan, H., Podelski, A., Wehrle, M.: Guided search for hybrid systems based on coarse-grained space abstractions. Int. J. Softw. Tools Technol. Transf. 18(4), 449–467 (2016). doi:10.1007/s10009-015-0393-y CrossRef Bogomolov, S., Donzé, A., Frehse, G., Grosu, R., Johnson, T.T., Ladan, H., Podelski, A., Wehrle, M.: Guided search for hybrid systems based on coarse-grained space abstractions. Int. J. Softw. Tools Technol. Transf. 18(4), 449–467 (2016). doi:10.​1007/​s10009-015-0393-y CrossRef
12.
Zurück zum Zitat Bogomolov, S., Frehse, G., Greitschus, M., Grosu, R., Pasareanu, C., Podelski, A., Strump, T.: Assume-guarantee abstraction refinement meets hybrid systems. In: Yahav, E. (ed.) HVC 2014. LNCS, vol. 8855, pp. 116–131. Springer, Heidelberg (2014) Bogomolov, S., Frehse, G., Greitschus, M., Grosu, R., Pasareanu, C., Podelski, A., Strump, T.: Assume-guarantee abstraction refinement meets hybrid systems. In: Yahav, E. (ed.) HVC 2014. LNCS, vol. 8855, pp. 116–131. Springer, Heidelberg (2014)
13.
Zurück zum Zitat Bogomolov, S., Schilling, C., Bartocci, E., Batt, G., Kong, H., Grosu, R.: Abstraction-based parameter synthesis for multiaffine systems. In: Piterman, N. (ed.) HVC 2015. LNCS, vol. 9434, pp. 19–35. Springer, Heidelberg (2015). doi:10.1007/978-3-319-26287-1_2 CrossRef Bogomolov, S., Schilling, C., Bartocci, E., Batt, G., Kong, H., Grosu, R.: Abstraction-based parameter synthesis for multiaffine systems. In: Piterman, N. (ed.) HVC 2015. LNCS, vol. 9434, pp. 19–35. Springer, Heidelberg (2015). doi:10.​1007/​978-3-319-26287-1_​2 CrossRef
14.
Zurück zum Zitat Cox, D.A., Little, J., O’Shea, D.: Ideals, Varieties and Algorithms: An Introduction to Computational Algebraic Geometry and Commutative Algebra. Springer, New York (2007)CrossRefMATH Cox, D.A., Little, J., O’Shea, D.: Ideals, Varieties and Algorithms: An Introduction to Computational Algebraic Geometry and Commutative Algebra. Springer, New York (2007)CrossRefMATH
15.
Zurück zum Zitat Dang, T., Le Guernic, C., Maler, O.: Computing reachable states for nonlinear biological models. In: Degano, P., Gorrieri, R. (eds.) CMSB 2009. LNCS, vol. 5688, pp. 126–141. Springer, Heidelberg (2009)CrossRef Dang, T., Le Guernic, C., Maler, O.: Computing reachable states for nonlinear biological models. In: Degano, P., Gorrieri, R. (eds.) CMSB 2009. LNCS, vol. 5688, pp. 126–141. Springer, Heidelberg (2009)CrossRef
16.
Zurück zum Zitat Dreossi, T., Dang, T.: Parameter synthesis for polynomial biological models. In: Proceedings of the 17th International Conference on Hybrid Systems: Computation and Control, pp. 233–242. ACM (2014) Dreossi, T., Dang, T.: Parameter synthesis for polynomial biological models. In: Proceedings of the 17th International Conference on Hybrid Systems: Computation and Control, pp. 233–242. ACM (2014)
17.
Zurück zum Zitat Grosu, R., Batt, G., Fenton, F.H., Glimm, J., Le Guernic, C., Smolka, S.A., Bartocci, E.: From cardiac cells to genetic regulatory networks. In: Gopalakrishnan, G., Qadeer, S. (eds.) CAV 2011. LNCS, vol. 6806, pp. 396–411. Springer, Heidelberg (2011)CrossRef Grosu, R., Batt, G., Fenton, F.H., Glimm, J., Le Guernic, C., Smolka, S.A., Bartocci, E.: From cardiac cells to genetic regulatory networks. In: Gopalakrishnan, G., Qadeer, S. (eds.) CAV 2011. LNCS, vol. 6806, pp. 396–411. Springer, Heidelberg (2011)CrossRef
18.
Zurück zum Zitat Habets, L., Collins, P.J., van Schuppen, J.H.: Reachability and control synthesis for piecewise-affine hybrid systems on simplices. IEEE Trans. Autom. Control 51(6), 938–948 (2006)MathSciNetCrossRef Habets, L., Collins, P.J., van Schuppen, J.H.: Reachability and control synthesis for piecewise-affine hybrid systems on simplices. IEEE Trans. Autom. Control 51(6), 938–948 (2006)MathSciNetCrossRef
19.
Zurück zum Zitat Habets, L., Van Schuppen, J.H.: A control problem for affine dynamical systems on a full-dimensional polytope. Automatica 40(1), 21–35 (2004)MathSciNetCrossRefMATH Habets, L., Van Schuppen, J.H.: A control problem for affine dynamical systems on a full-dimensional polytope. Automatica 40(1), 21–35 (2004)MathSciNetCrossRefMATH
20.
Zurück zum Zitat Habets, L.C.G.J.M., Van Schuppen, J.: A control problem for affine dynamical systems on a full-dimensional simplex. Rep. Probab. Netw. Algorithms 17, 1–19 (2000) Habets, L.C.G.J.M., Van Schuppen, J.: A control problem for affine dynamical systems on a full-dimensional simplex. Rep. Probab. Netw. Algorithms 17, 1–19 (2000)
21.
Zurück zum Zitat Jiang, Y., Zhang, H., Li, Z., Deng, Y., Song, X., Gu, M., Sun, J.: Design and optimization of multiclocked embedded systems using formal techniques. IEEE Trans. Ind. Electron. 62(2), 1270–1278 (2015)CrossRef Jiang, Y., Zhang, H., Li, Z., Deng, Y., Song, X., Gu, M., Sun, J.: Design and optimization of multiclocked embedded systems using formal techniques. IEEE Trans. Ind. Electron. 62(2), 1270–1278 (2015)CrossRef
22.
Zurück zum Zitat Jiang, Y., Zhang, H., Zhang, H., Liu, H., Song, X., Gu, M., Sun, J.: Design of mixed synchronous/asynchronous systems with multiple clocks. IEEE Trans. Parallel Distrib. Syst. 26(8), 2220–2232 (2015)CrossRef Jiang, Y., Zhang, H., Zhang, H., Liu, H., Song, X., Gu, M., Sun, J.: Design of mixed synchronous/asynchronous systems with multiple clocks. IEEE Trans. Parallel Distrib. Syst. 26(8), 2220–2232 (2015)CrossRef
23.
Zurück zum Zitat Kloetzer, M., Belta, C.: Reachability analysis of multi-affine systems. In: Hespanha, J.P., Tiwari, A. (eds.) HSCC 2006. LNCS, vol. 3927, pp. 348–362. Springer, Heidelberg (2006)CrossRef Kloetzer, M., Belta, C.: Reachability analysis of multi-affine systems. In: Hespanha, J.P., Tiwari, A. (eds.) HSCC 2006. LNCS, vol. 3927, pp. 348–362. Springer, Heidelberg (2006)CrossRef
24.
Zurück zum Zitat Kong, H., Bogomolov, S., Schilling, C., Jiang, Y., Henzinger, T.A., Invariant clusters for hybrid systems. arXiv preprint arXiv: 1605.01450 (2016) Kong, H., Bogomolov, S., Schilling, C., Jiang, Y., Henzinger, T.A., Invariant clusters for hybrid systems. arXiv preprint arXiv:​ 1605.​01450 (2016)
25.
Zurück zum Zitat Kong, H., He, F., Song, X., Hung, W.N.N., Gu, M.: Exponential-condition-based barrier certificate generation for safety verification of hybrid systems. In: Sharygina, N., Veith, H. (eds.) CAV 2013. LNCS, vol. 8044, pp. 242–257. Springer, Heidelberg (2013)CrossRef Kong, H., He, F., Song, X., Hung, W.N.N., Gu, M.: Exponential-condition-based barrier certificate generation for safety verification of hybrid systems. In: Sharygina, N., Veith, H. (eds.) CAV 2013. LNCS, vol. 8044, pp. 242–257. Springer, Heidelberg (2013)CrossRef
26.
Zurück zum Zitat Kong, H., Song, X., Han, D., Gu, M., Sun, J.: A new barrier certificate for safety verification of hybrid systems. Comput. J. 57(7), 1033–1045 (2014)CrossRef Kong, H., Song, X., Han, D., Gu, M., Sun, J.: A new barrier certificate for safety verification of hybrid systems. Comput. J. 57(7), 1033–1045 (2014)CrossRef
27.
Zurück zum Zitat Liu, J., Zhan, N., Zhao, H.: Computing semi-algebraic invariants for polynomial dynamical systems. In: International Conference on Embedded Software, pp. 97–106. ACM (2011) Liu, J., Zhan, N., Zhao, H.: Computing semi-algebraic invariants for polynomial dynamical systems. In: International Conference on Embedded Software, pp. 97–106. ACM (2011)
28.
Zurück zum Zitat Sogokon, A., Ghorbal, K., Jackson, P.B., Platzer, A.: A method for invariant generation for polynomial continuous systems. In: Jobstmann, B., Leino, K.R.M. (eds.) VMCAI 2016. LNCS, vol. 9583, pp. 268–288. Springer, Heidelberg (2016). doi:10.1007/978-3-662-49122-5_13 CrossRef Sogokon, A., Ghorbal, K., Jackson, P.B., Platzer, A.: A method for invariant generation for polynomial continuous systems. In: Jobstmann, B., Leino, K.R.M. (eds.) VMCAI 2016. LNCS, vol. 9583, pp. 268–288. Springer, Heidelberg (2016). doi:10.​1007/​978-3-662-49122-5_​13 CrossRef
29.
Zurück zum Zitat Tiwari, A.: Abstractions for hybrid systems. Formal Methods Syst. Des. 32(1), 57–83 (2008)CrossRefMATH Tiwari, A.: Abstractions for hybrid systems. Formal Methods Syst. Des. 32(1), 57–83 (2008)CrossRefMATH
30.
Zurück zum Zitat Tiwari, A., Khanna, G.: Series of abstractions for hybrid automata. In: Tomlin, C.J., Greenstreet, M.R. (eds.) HSCC 2002. LNCS, vol. 2289, pp. 465–478. Springer, Heidelberg (2002)CrossRef Tiwari, A., Khanna, G.: Series of abstractions for hybrid automata. In: Tomlin, C.J., Greenstreet, M.R. (eds.) HSCC 2002. LNCS, vol. 2289, pp. 465–478. Springer, Heidelberg (2002)CrossRef
Metadaten
Titel
Discrete Abstraction of Multiaffine Systems
verfasst von
Hui Kong
Ezio Bartocci
Sergiy Bogomolov
Radu Grosu
Thomas A. Henzinger
Yu Jiang
Christian Schilling
Copyright-Jahr
2016
DOI
https://doi.org/10.1007/978-3-319-47151-8_9