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2017 | OriginalPaper | Buchkapitel

A New Approximation Algorithm for the Maximum Stacking Base Pairs Problem from RNA Secondary Structures Prediction

verfasst von : Aizhong Zhou, Haitao Jiang, Jiong Guo, Daming Zhu

Erschienen in: Combinatorial Optimization and Applications

Verlag: Springer International Publishing

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Abstract

This paper investigates the problem of maximum stacking base pairs from RNA secondary structure prediction. The basic version of maximum stacking base pairs problem as: given an RNA sequence, to find a maximum number of base pairs where each base pair is involved in a stacking. Ieong et al. showed this problem to be NP-hard, where the candidate base pairs follow some biology principle and are given implicitly. In this paper, we study the version of this problem that the candidate base pairs are given explicitly as input, and present a new approximation algorithm for this problem by the local search method, improving the approximation factor from 5/2 to 7/3. The time complexity is within \(O(n^{14})\), since we adopt 1-substitution and special 2-substitutions in the local improvement steps.

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Metadaten
Titel
A New Approximation Algorithm for the Maximum Stacking Base Pairs Problem from RNA Secondary Structures Prediction
verfasst von
Aizhong Zhou
Haitao Jiang
Jiong Guo
Daming Zhu
Copyright-Jahr
2017
DOI
https://doi.org/10.1007/978-3-319-71150-8_7