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Ir-Catalyzed Functionalization of C–H Bonds

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Iridium Catalysis

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 34))

Abstract

The ability to selectively functionalize C–H bonds holds enormous potential value in virtually every sphere of organic chemistry, from fuels to pharmaceuticals. Transition metal complexes have shown great promise in this context. Iridium provided the first examples of oxidative addition of C–H bonds; this addition is key to iridium’s leading role in alkane dehydrogenation and related reactions. Catalysts based on iridium have also proven highly effective for valuable borylations of C–H bonds and, to a lesser extent, for C–Si coupling. Compared with other platinum group metals, iridium chemistry has not been developed as extensively for the elaboration of C–C bonds from C–H bonds, but significant promise is indicated, particularly for coupling with simple hydrocarbons which lack functionalities that can act as directing groups.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08903, USA

    Jongwook Choi & Alan S. Goldman

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  1. Jongwook Choi
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  2. Alan S. Goldman
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Correspondence to Alan S. Goldman .

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Editors and Affiliations

  1. Dept. Biochemistry & Organic Chemistry, Uppsala University, Uppsala, Sweden

    Pher G. Andersson

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Choi, J., Goldman, A.S. (2011). Ir-Catalyzed Functionalization of C–H Bonds. In: Andersson, P. (eds) Iridium Catalysis. Topics in Organometallic Chemistry, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15334-1_6

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