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Erschienen in:
2013 | OriginalPaper | Buchkapitel
A Temporal Logic Approach to Modular Design of Synthetic Biological Circuits
verfasst von : Ezio Bartocci, Luca Bortolussi, Laura Nenzi
Erschienen in: Computational Methods in Systems Biology
Verlag: Springer Berlin Heidelberg
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We present a new approach for the design of a synthetic biological circuit whose behaviour is specified in terms of signal temporal logic (STL) formulae. We first show how to characterise with STL formulae the input/output behaviour of biological modules miming the classical logical gates (AND, NOT, OR). Hence, we provide the regions of the parameter space for which these specifications are satisfied. Given a STL specification of the target circuit to be designed and the networks of its constituent components, we propose a methodology to constrain the behaviour of each module, then identifying the subset of the parameter space in which those constraints are satisfied, providing also a measure of the robustness for the target circuit design. This approach, which leverages recent results on the quantitative semantics of Signal Temporal Logic, is illustrated by synthesising a biological implementation of an half-adder.