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Enantio- and Diastereoselectivity of Microsomal Epoxide Hydrolase: Potential Applications to the Preparation of Non-Racemic Epoxides and Diols

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Enzymes as Catalysts in Organic Synthesis

Part of the book series: NATO ASI Series ((ASIC,volume 178))

Abstract

The conversion of epoxides into trans-diols, catalyzed by microsomal epoxide hydrolase (MEH) is reviewed from the point of view of the relations between substrate structure and the regio-and stereoselectivity of the enzyme. Several examples of reactions exhibiting a high enantioselectivity are given and the possibility of using the method for the purpose of preparing chiral epoxides and diols of high optical purity is discussed.

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Author information

Authors and Affiliations

  1. Institute of Organic Chemistry, Faculty of Pharmacy, University of Pisa, Via Bonanno, 6, 56100, Pisa, Italy

    G. Berti

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  1. G. Berti
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Editor information

Editors and Affiliations

  1. University of Wuppertal, Germany

    M. P. Schneider

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© 1986 D. Reidel Publishing Company

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Berti, G. (1986). Enantio- and Diastereoselectivity of Microsomal Epoxide Hydrolase: Potential Applications to the Preparation of Non-Racemic Epoxides and Diols. In: Schneider, M.P. (eds) Enzymes as Catalysts in Organic Synthesis. NATO ASI Series, vol 178. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4686-6_23

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  • DOI: https://doi.org/10.1007/978-94-009-4686-6_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8583-0

  • Online ISBN: 978-94-009-4686-6

  • eBook Packages: Springer Book Archive

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