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A group-theoretic approach to rings of coupled biological oscillators

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Abstract

In this paper, a general approach for studying rings of coupled biological oscillators is presented. This approach, which is group-theoretic in nature, is based on the finding that symmetric ring networks of coupled non-linear oscillators possess generic patterns of phaselocked oscillations. The associated analysis is independent of the mathematical details of the oscillators' intrinsic dynamics and the nature of the coupling between them. The present approach thus provides a framework for distinguishing universal dynamic behaviour from that which depends upon further structure. In this study, the typical oscillation patterns for the general case of a symmetric ring of n coupled non-linear oscillators and the specific cases of three- and five-membered rings are considered. Transitions between different patterns of activity are modelled as symmetry-breaking bifurcations. The effects of one-way coupling in a ring network and the differences between discrete and continuous systems are discussed. The theoretical predictions for symmetric ring networks are compared with physiological observations and numerical simulations. This comparison is limited to two examples: neuronal networks and mammalian intestinal activity. The implications of the present approach for the development of physiologically meaningful oscillator models are discussed.

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Authors and Affiliations

  1. NeuroMuscular Research Center and Department of Biomedical Engineering, Boston University, 02215, Boston, MA, USA

    J. J. Collins

  2. Nonlinear Systems Laboratory, Mathematics Institute, University of Warwick, CV4 7AL, Coventry, UK

    I. Stewart

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  1. J. J. Collins
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  2. I. Stewart
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Collins, J.J., Stewart, I. A group-theoretic approach to rings of coupled biological oscillators. Biol. Cybern. 71, 95–103 (1994). https://doi.org/10.1007/BF00197312

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  • DOI: https://doi.org/10.1007/BF00197312

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