Summary
Neural cuffs, implanted around various hindlimb nerves (sural, common peroneal, posterior tibial), were used to deliver brief stimulus trains to unrestrained cats walking on a treadmill. The resulting perturbations of the step cycle were evaluated by analyzing the EMG bursts recorded from the ankle extensors and by high speed cinematography. It was found that relatively weak stimulation (1.4 to 2 X T) of the posterior tibial nerve was very effective in eliciting a prolongation of the flexion phase provided the stimuli were applied just prior to the expected onset of the ankle extensor EMG burst. This ipsilateral hyperflexion was correlated with a prolongation of the contralateral extension. The same stimuli applied during stance usually evoked a yielding of the stimulated leg and a prolongation of the ongoing contralateral stance. In addition to these flexor and extensor reflex effects, it was found that low threshold stimulation of the sural and common peroneal nerves resulted in a powerful reflex activation of the ankle extensors. In contrast, stimulation of the gastrocnemius-soleus nerve (a muscle nerve) produced no discernible behavioral effects, even for stimuli at 3 X T, indicating that the observed reflexes are probably mediated by cutaneous afferents. The results were largely confirmed in experiments using the same cuffs implanted in spontaneously walking premammillary cats.
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Brown, T.G.: On the nature of the fundamental activity of the nervous centres: together with an analysis of the conditioning of rhythmic activity in progression, and a theory of the evolution of function in the nervous system. J. Physiol. (Lond.) 48, 18–46 (1914)
Creed, R.S., Denny-Brown, D., Eccles, J.C., Liddell, E.G.T., Sherrington, C.S.: Reflex Activity of the Spinal Cord. London: Oxford University Press 1932
Duysens, J.: Reflex control of locomotion as revealed by stimulation of cutaneous afferents in spontaneously walking premammillary cats. J. Neurophysiol. 40, 737–751 (1977)
Duysens, J., Pearson, K.G.: The role of cutaneous afferents from the distal hindlimb in the regulation of the step cycle of thalamic cats. Exp. Brain Res. 24, 245–255 (1976)
Forssberg, H., Grillner, S., Rossignol, S.: Phase dependent reflex reversal during walking in chronic spinal cats. Brain Res. 85, 103–107 (1975)
Forssberg, H., Grillner, S., Rossignol, S., Wallen, P.: Phasic control of reflexes during locomotion in vertebrates. In: Neural Control of Locomotion (eds. R.M. Herman, S. Grillner, P.S.G. Stein, D.G. Stuart), pp. 647–674. New York: Plenum Press 1976
Grillner, S.: Locomotion of vertebrates: central mechanisms and reflex interaction. Physiol. Rev. 55, 247–304 (1975)
Hagbarth, K.-E.: Excitatory and inhibitory skin areas for flexor and extensor motoneurons. Acta physiol. scand. Suppl. 94, 26 (1952)
Kanda, K., Burke, R.E., Walmsley, B.: Differential control of fast and slow motor units in the decerebrate cat. Exp. Brain Res. (In press)
Lundberg, A.: Reflex control of stepping. The Nansen Memorial Lecture V, pp. 1–42. Oslo: Universitetsforlaget 1969
Orlovskii, G.N., Shik, M.L.: Standard elements of cyclic movements. Biofizika l0, 847–854 (1965)
Prochazka, A., Westerman, R.A., Ziccone, S.P.: Discharges of single hindlimb afferents in the freely moving cat. J. Neurophysiol. 39, 1090–1104 (1976)
Prochazka, A., Westerman, R.A., Ziccone, S.P.: la afferent activity during a variety of voluntary movements in the cat. J. Physiol. (Lond.) 268, 423–448 (1977)
Sherrington, C.S.: Flexion-reflex of the limb, crossed extension reflex and reflex stepping and standing. J. Physiol. (Lond.) 40, 28–131 (1910)
Sherrington, C.S.: Further observations on the production of reflex inhibition. J. Physiol. (Lond.) 47, 196–214 (1913)
Stein, R.B., Charles, D., Davis, L., Jhamandas, J., Mannard, A., Nichols, T.R.: Principles underlying new methods for chronic neural recording. Can. J. Neurol. Sci. 2, 235–244 (1975)
Stein, R.B., Nichols, T.R., Jhamandas, J., Davis, L.: Stable longterm recordings from cat peripheral nerves. Brain Res. 128, 21–38 (1977)
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Duysens, J., Stein, R.B. Reflexes induced by nerve stimulation in walking cats with implanted cuff electrodes. Exp Brain Res 32, 213–224 (1978). https://doi.org/10.1007/BF00239728
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DOI: https://doi.org/10.1007/BF00239728