Skip to main content
SpringerLink
Log in

Synthesis and preliminary characterization of polyesteramides containing enzymatically degradable amide bonds

  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Summary

Multiblock and regularly alternating biodegradable polyesteramides containing amide bonds susceptible of enzymatic cleavage were prepared and preliminarly characterized by viscosity, IR, 1H-NMR and DSC techniques. L-phenylalanine was used to build up amide linkages containing a phenyl ring adjacent to the acyl group, enzymatically cleavable by chymotrypsin. Monomers having preformed ester groups or biodegradable amide bonds and/or telechelic oligomers of poly(L-lactide) were used as starting materials. Their chain length was regularly increased in order to improve the overall chain flexibility and, hence, to favour the enzymatic attack.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Huang S.J. in Encyclopedia of Polymer Science and Engineering, Mark H.F., Bikales, N.M., Overberger C.G., Menges G., Eds, Wiley, N.Y., 1985, vol 2, 220.

    Google Scholar 

  2. Williams D.F. in Comprehensive Polymer Science, Eastmond G.C., Ledwith A., Russo S., Sigwalt P., Eds, Pergamon Press, London, 1989, vol 6, 607.

    Google Scholar 

  3. Tunc D.C., Jadhav B., in Progress in Biomedical Polymers, Gebelein C.G., Dunn R.L., Eds, Plenum Press, 1990, 239.

  4. Andini S., Ferrara L.. Maglio G., Palumbo R., Makromol. Chem. Rapid Commun. 9, 119 (1988).

    Google Scholar 

  5. De Simone V., Maglio G., Palumbo R., Scardi V., J. Appl. Polym. Sci. (submitted).

  6. Tsamantakis A., Carriere F., Die Angew. Makromol. Chem. 104, 19 (1982).

    Google Scholar 

  7. Schroder E., Klieger E., Gibian H., Justus Liebigs Ann. Chem. 646, 101 (1961).

    Google Scholar 

  8. Jatzkewitz H., Naturforsch Z., Teil B., 10, 27 (1955).

    Google Scholar 

  9. Fu T.Y., Morawetz H., J. Biol. Chem. 251, 2083 (1976).

    Google Scholar 

  10. Drobnik J., Kopecek J., Labsky J, Reimanova P., Exner J., Saudek V., Kalal J., Makromol. Chem. 177, 2833 (1976).

    Google Scholar 

  11. Huang S.J., Bansleben D.A., Knox J.R., J. Appl. Polym. Sci. 23, 429 (1979).

    Google Scholar 

  12. Kopecek J., Reimanova P., Chytry V., Makrom. Chem. 182, 799 (1981).

    Google Scholar 

  13. Ulbrich K., Strohalm J., Kopecek J., Makromol. Chem. 187, 131 (1986).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dipartimento di Chimica, Università “Federico II”, Via Mezzocannone 4, I-80134, Napoli, Italy

    L. Castaldo, P. Corbo, G. Maglio & R. Palumbo

Authors
  1. L. Castaldo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Corbo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Maglio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Palumbo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Castaldo, L., Corbo, P., Maglio, G. et al. Synthesis and preliminary characterization of polyesteramides containing enzymatically degradable amide bonds. Polymer Bulletin 28, 301–307 (1992). https://doi.org/10.1007/BF00294826

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00294826

Keywords

Search

Navigation