Abstract
Controlled release of L-ascorbic acid from poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels is reported. PHEMA hydrogels were synthesized from 2-hydroxyethyl methacrylate (HEMA) monomer in an oven. We studied the swelling of PHEMA discs in water as a fuction of temperature and thickness of xerogel discs. The fractional swelling was linear in (time)1/2 at short times. Drug release has been examined as a fuction of temperature, initial drug load and thickness of the PHEMA discs. The fraction of avaible drug release was linear in (time)1/2 during the initial stage too. The release experiments were carried out at 308 K. These studies allow to determinate a diffusion coefficient for transport of water into the hydrogels and a diffusion coefficient for L-ascorbic acid release from the hydrogel.
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Trigo, R.M., Blanco, M.D., Huerta, P. et al. l-Ascorbic acid release from phema hydrogels. Polymer Bulletin 31, 577–584 (1993). https://doi.org/10.1007/BF00297895
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DOI: https://doi.org/10.1007/BF00297895