Abstract
An unknown antibiotic, ophiocordin, C21H22N2O8, MW: 430, was isolated from submerged cultures of Cordyceps ophioglossoides, strain TÜ 276, grown in a glycerol soybean meal medium at 27°C. The antibiotic was extracted from acidified culture fluids with n-butanol and purified by subsequent column chromatography on DEAE-Sephadex and cellulose. Studies including nuclear magnetic resonance and mass spectrometry resulted in proposals of partial structures of the molecule. Inhibition by ophiocordin could be demonstrated for a small number of fungi belonging to different taxonomic groups. Bacteria were not inhibited. The antifungal effect was antagonized by ammonia and nitrate ions and by certain amino acids.
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Metabolic products of microorganisms, 161st Communication. 160. Mitteilung: J. M. Müller, H. Fuhrer, J. Gruner, and W. Voser: Conocandin, ein fungistatisches Antibiotikum aus Hormococcus conorum (Sacc. et Roum.) Roback. Helv. chim. Acta 59, 2506–2514 (1976)
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Kneifel, H., Konig, W.A., Loeffler, W. et al. Ophiocordin, an antifungal antibiotic of Cordyceps ophioglossoides . Arch. Microbiol. 113, 121–130 (1977). https://doi.org/10.1007/BF00428591
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DOI: https://doi.org/10.1007/BF00428591