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Absorbable self-reinforced polylactide (SR-PLA) composite rods for fracture fixation: strength and strength retention in the bone and subcutaneous tissue of rabbits

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Abstract

The strength and strength retention of self-reinforced (SR) absorbable polylactic acid composite rods were evaluated after intramedullary and subcutaneous implantation in rabbits. Rods made of poly-l-lactic acid (SR-PLLA) and of poly-dl-lactic acid + poly-l-lactic acid composite (SR-PDLLA/PLLA) were used. The molecular mass (M v) of PLLA was 260.000 and that of PDLLA 100.000. The bending and shear strengths were measured after a follow-up of 1–48 weeks. The initial bending strength of the SR-PLLA rods was 250–271 MPa and the shear strength was 94 98 MPa. After intramedullary and subcutaneous implantation of 12 weeks the bending strength of the SR-PLLA implants was 100 MPa. At 36 weeks the bending strength had decreased to the level of the strength of cancellous bone (10–20 MPa). There were no changes in the shear strength during 12 weeks hydrolysis. The initial bending strength of SR-PDLLA/PLLA implants was 209 MPa and during the follow-up the implants lost their bending and shear strength faster than the SR-PLLA implants. The present investigation gave us the impetus to continue the studies with the fixation of experimental cortical bone osteotomies with SR-PLLA intramedullary rods.

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Authors and Affiliations

  1. The Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, SF-00260, Helsinki, Finland

    A. Majola, S. Vainionpää & P. Rokkanen

  2. Biomaterials Laboratory, Institute of Plastics Technology, Tampere University of Technology, Tampere, Finland

    H. -M. Mikkola & P. Törmälä

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  1. A. Majola
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  2. S. Vainionpää
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  3. P. Rokkanen
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  4. H. -M. Mikkola
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  5. P. Törmälä
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Majola, A., Vainionpää, S., Rokkanen, P. et al. Absorbable self-reinforced polylactide (SR-PLA) composite rods for fracture fixation: strength and strength retention in the bone and subcutaneous tissue of rabbits. J Mater Sci: Mater Med 3, 43–47 (1992). https://doi.org/10.1007/BF00702943

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