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Tubulointerstitial nephritis in methylmalonic acidemia

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Abstract

We report two patients with methylmalonic acidemia (MMA) in whom renal biopsy demonstrated interstitial nephritis, bringing the total of such reported cases to four. In addition, hypertension, observed in one of our patients, has not been previously reported as the presentation of renal disease in MMA. The etiology of interstitial nephritis in MMA did not appear to be due to urate nephropathy. To date, 15 patients with MMA have been reported with renal complications, including chronic renal failure, making it imperative that children with MMA have their renal status evaluated.

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References

  1. Walter JH, Michalski A, Wilson WM, Leonard JV, Barratt TM, Dillon MJ (1989) Chronic renal failure in methylmalonic acidemia. Eur J Pediatr 148:344–348

    PubMed  Google Scholar 

  2. Wolff JA, Strom C, Griswold W, Sweetman F, Kulovich S, Prodanos C, Nyhan WL (1991) Renal tubular acidosis in methylmalonic acidemia. J Neurogenet 2:31–39

    Google Scholar 

  3. Molteni KH, Oberly TD, Wolff JA, Friedman AL (1991) Progressive renal insufficiency in methylmalonic acidemia. Pediatr Nephrol 5:323–326

    PubMed  Google Scholar 

  4. Morita J, Ito Y, Yoshino M, Koga Y, Yano S, Yoshida I, Yamashita (1989) Persistent hyperkalemia in vitamin B12 unresponsive methylmalonic acidemia. J Inherited Metab Dis 12:89–93

    Google Scholar 

  5. Whelan DT, Ryan E, Spate M, Morris M, Hurley RM, Hill R (1979) Methylmalonic acidemia: 6 years' clinical experience with two variants unresponsive to vitamin B12 therapy. Can Med Assoc J 120:1230–1235

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, University of Alabama at Birmingham, Alabama, USA

    S. Lane Rutledge & Ed Kohout

  2. Department of Pathology, The Children's Hospital, 1600 7th Avenue South, 35233, Birmingham, Alabama, USA

    Elizabeth Mroczek

  3. Department of Medicine, McGill University, Montreal, Quebec, Canada

    David Rosenblatt

  4. Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA

    Michael Geraghty

Authors
  1. S. Lane Rutledge
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  2. Michael Geraghty
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  3. Elizabeth Mroczek
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  4. David Rosenblatt
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  5. Ed Kohout
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Rutledge, S.L., Geraghty, M., Mroczek, E. et al. Tubulointerstitial nephritis in methylmalonic acidemia. Pediatr Nephrol 7, 81–82 (1993). https://doi.org/10.1007/BF00861581

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  • DOI: https://doi.org/10.1007/BF00861581

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