Summary
A quasi-valence number of less than 3.20 was reported to be significant in correlating carcinogenicity. This criterion has no meaningful relationship since such a large proportion of organic compounds fall in this group, that it provides no selectivity.
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References
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Acknowledgment. The authors express appreciation to the American Cancer Society (CH-57), the National Institute of Environmental Health Sciences (1-RO1-ES01975-01 PTHB) and the Robert A. Welch Foundation (B-702) for financial assistance of projects related to this paper.
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Lyle, R.E., Lyle, G.G. Comments on the significance of the quasi-valence number for chemical carcinogenesis. Experientia 34, 1653–1654 (1978). https://doi.org/10.1007/BF02034733
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DOI: https://doi.org/10.1007/BF02034733