Skip to main content
SpringerLink
Log in

Technetium-99m generators based on neutron irradiated 12-molybdocerate as column matrix

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Neutron irradiated 12-molybdocerate(IV) is evaluated as a column matrix for use in preparation of small chromatographic column type99mTc generators. Greater than 87% of the generated99mTc activity is immediately and reproducibly eluted with passing 10 cm3 of saline or chromated saline solutions through 3.0 g of molybdocerate column bed at flow rates of about 1.0 cm3/min. The elution performance of99mTc does not drastically change with increasing the drying temperature and/or the particles sixe of the column matrix in the range investigated. Saline eluent containing 5·10−5M CrO 2−4 increases the radiochemical purity of the eluate to >98% TcO −4 . Radionuclidic and chemical purities of the eluates satisfy the specifications for use in nuclear medicine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. RICHARDS, A Survey of the Production of Brookhaven National Laboratory of Radioisotopes for Medical Research, V. Congresso Nuclear, Vol. 2, 1960, p. 225.

    Google Scholar 

  2. Radiopharmaceuticals from Generator-Produded Radionuclides, Panel Proc. Series STI/PUB/294, Vienna, IAEA, 1971.

  3. W. C. ECKELMAN, B. M. COURSAY (Eds), Int. J. Appl. Radiation Isotopes, 33 (1982) 10.

  4. R. E. BOYD, Radiochim. Acta, 30 (1982) 123.

    Google Scholar 

  5. H. ARINO, H. H. KRAMER, Int. J. Appl. Radiation Isotopes, 26 (1975) 301.

    Article  Google Scholar 

  6. M. A. EL ABSY, Radiochim. Acta, 55 (1991) 23 and references therein.

    Google Scholar 

  7. Fission Molybdenum for Medical USE, IAEA TECDOC-515, Vienna, IAEA, 1989.

  8. J. J. PINAJIAN, Int. J. Appl. Radiation Isotopes, 17 (1966) 664.

    Article  Google Scholar 

  9. M. GUILLAUME, Radiochim. Radioanal., Letters, 13 (1973) 307.

    Google Scholar 

  10. A. MUSHTAQ, M. S. MANSOOR, H. M. A. KARIM, M. A. KHAN, J. Radioanal. Nucl. Chem., 147 (1991) 257.

    Google Scholar 

  11. V. I. LEVIN, L. S. KOZYREVA-ALEXANDRA, T. SOKOLOVA, T. L. BAGENOVA, Int. J. Appl. Radiation Isotopes, 30 (1979) 450.

    Article  Google Scholar 

  12. V. I. SPITSYN, N. B. MIKHEEV, At. Energy Rev., 9 (1971) 827.

    Google Scholar 

  13. M. ANWAR, K. LATHROP, D. ROSSKELLY, P. V. HARPER, J. Nucl. Med., 9 (1968) 298.

    Google Scholar 

  14. E. HALLABA, H. A. EL ASRAG, Isotopenpraxis, 11 (1975) 290.

    Google Scholar 

  15. L. ZSINKA, Radiochim. Acta, 41 (1987) 91 and reference therein.

    Google Scholar 

  16. T. BRAUN, H. IMURA, R. SUZUKI, J. Radioanal. Nucl. Chem., 119 (1987) 315.

    Google Scholar 

  17. D. V. S. NARASIMHAN, KUM P. VANAJA, R. S. MANI, J. Radioanal. Nucl. Chem., 85 (1984) 345.

    Google Scholar 

  18. J. V. EVANS, P. W. MOORE, Proc. World Congress of Nuclear Medicine and Biology, Paris, 1982.

  19. D. V. S. NARASIMHAN, KUM P. VANAJA, R. S. MANI, J. Radioanal. Nucl. Chem., 85 (1984) 163.

    Google Scholar 

  20. J. V. EVANS, P. W. MOORE, M. E. SHYING, J. M. SODEAU, Appl. Radiat. Isot., 38 (1987) 19, 25.

    Google Scholar 

  21. SÁNCHEZ-OCAMPO, S. BULBULIAN, Intern. J. Appl. Radiation Isotope, 42 (1991) 1073.

    Article  Google Scholar 

  22. M. A. EL ABSY, S. EL BAYOUMY, Isotopenpraxis, 26 (1990) 60.

    Google Scholar 

  23. M. A. EL ABSY, I. M. EL NAGGAR, A. I. AUDAH. J. Radioanal. Nucl. Chem., 173 (1993) 185.

    Google Scholar 

  24. K. SVOBODA, J. LEZAMA, J. TENDILLA, F. MELICHAR, M. TYMPL, J. Radioanal. Nucl. Chem., 96 (1985) 405.

    Google Scholar 

  25. P. VANAJA, N. RAMAMOORTHY, S. P. IYER, R. S. MANI, Radiochim. Acta, 42 (1987) 49.

    Google Scholar 

  26. N. RAMAMOORTHY, P. VANAJA, S. P. IYER, R. S. MANI, Intern. Symp. on Artificial Radioactivity, Pune, India, 1985.

  27. N. RAMAMOORTHY, P. VANAJA, S. P. IYER, R. S. MANI, Seminar on Radionuclide Generator Technology, IAEA-SR-131/23, Vienna, 1986.

  28. E. B. SANDELL, Colorimetric Determination of Traces of Matals, Interscience Publishers, Inc. New York, 1959.

    Google Scholar 

  29. S. A. COTTON, F. A. HART, The Heavy Transiton Elements, Macmillan, London and Basingstoke, 1975.

  30. P. SANDRU, A. TOPA, Radionuclizii, Academiei Republicii Socialiste Romania, Bucharest, 1968.

    Google Scholar 

  31. G. ERDTMANN, W. SOYKA, Die γ-Linien der Radionuklide, Vol. 1, Jül-1003-AC, 1973.

  32. P. GALLE, R. MASSE (Eds), Radionuclide Metabolism and Toxicity, Masson, Paris-New York-Barcelone-Milan-Mexico-Rio de Janeiro, 1982.

    Google Scholar 

  33. J. BONNYMAN, Int. J. Appl. Radiation Isotopes, 34 (1983) 901.

    Article  Google Scholar 

  34. J. H. ZAIDI, H. M. A. KARIM, M. ARIF, I. H. QURESHI, Radiochim. Acta, 49 (1990) 107.

    Google Scholar 

  35. H. S. STERN, I. ZOLLE, J. G. McFREE, Int. J. Appl. Radiation Isotopes, 16 (1965) 283.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Radioisotope Production Department, Atomic Energy Establishment, P.O. Code 13759, Cairo, (Egypt.)

    M. A. El-Absy & A. I. Audah

  2. Nuclear Chemistry Department, Atomic Energy Establishment, P.O. Code 13759, Cairo, (Egypt.)

    I. M. El-Naggar

Authors
  1. M. A. El-Absy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. M. El-Naggar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. I. Audah
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

El-Absy, M.A., El-Naggar, I.M. & Audah, A.I. Technetium-99m generators based on neutron irradiated 12-molybdocerate as column matrix. Journal of Radioanalytical and Nuclear Chemistry, Articles 183, 339–350 (1994). https://doi.org/10.1007/BF02038002

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02038002

Keywords

Search

Navigation