References
Alam, M. andF. H. Smirk, Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J. Physiol. London89, 372–377 (1937).
Alam, M. andF. H. Smirk, Blood pressure raising reflex in health, essential hypertension and renal hypertension. Clin. Sci.3, 259–269 (1938).
Alam, M. andF. H. Smirk, Unilateral loss of a blood pressure raising, pulse accelerating reflex from voluntary muscle due to a lesion of spinal cord. clin. Sci.3, 247–258 (1938).
Andrew, G., C. Guzman andM. Becklake, Effect of athletic training on exercise cardiac output. J. Appl. Physiol.21, 603–608 (1966).
Asmussen, E., Exercise: general statement of unsolved problems. Circul. Res.20, Suppl. I, 2–6 (1967).
Asmussen, E., M. Nielsen andK. Wieth-Pedersen, Cortical or reflex control of respiration during muscular work. Acta physiol. Scand.6, 168–175 (1943).
Asmussen, E. andM. Nielsen, Cardiac output during muscular work and its regulation. Physiol. Rev.35, 778–800 (1959).
Asmussen, E. andM. Nielsen, Experiments of nervous factors controlling respiration and circulation during exercise. Acta physiol. scand.60, 103–111 (1964).
Asmussen, E., S. H. Johansen, M. Jorgensen andM. Nielsen, On the nervous factors controlling respiration and circulation during exercise. Acta physiol. Scand.63, 343–350 (1965).
Astrand, P. O. andP. Ryhming, A nomogram for calculation of aerobic capacity (pysical fitness) from pulse rate during submaximal work. J. Appl. Physiol.7, 218–221 (1954).
Astrand, P. O., T. E. Cuddy, B. Saltin andJ. Stenberg, Cardiac output during submaximal and maximal work. J. Appl. Physiol.19, 268–274 (1964).
Bainbridge, F. A., The physiology of muscular exercise (London 1929).
Barcroft, H. andJ. L. E. Millen, The blood flow through muscle during sustained contractions. J. Physiol. London97, 17–31 (1939).
Berggren, G. andE. H. Christensen, Pulsfrequenz und Körpertemperatur als Indices der Stoffwechselgröße während der Arbeit. Arbeitsphysiologie14, 225–261 (1950).
Bergstrom, J., Local changes of ATP and Phosphorylcreatine in human muscle tissue in connection with exercise. Circul. Res.20, Suppl. I, 91–96 (1967).
Bevegard, B. S., andJ. T. Shepherd, Circulatory effects of stimulating the carotis stretch receptors in man at rest and during exercise. J. Clin. Invest.45, 132–142 (1966).
Bevegard, B. S. andJ. T. Shepherd, Regulation of the circulation during exercise in man. Physiol. Rev.47, 178–213 (1967).
Bevegard, B. S., U. Freyschuss andT. Strandell, Circulatory adaptation to arm and leg exercise in supine and sitting position. J. Appl. Physiol.21, 37–46 (1966).
Blair, D., A. Glover andI. C. Roddie, Vasomotor responses in the human arm during leg exercise. Circul. Res.9, 264–274 (1961).
Böning, D., Veränderungen der CO2-Bindungskurve des Blutes bei akuter respiratorischer Acidose und ihre Ursachen. Pflügers Arch. ges. Physiol.302, 1233–148 (1968).
Braunwald, E., E. H. Sonnenblick, J. Ross, G. Glick andS. E. Epstein, An analysis of the cardiac response to exercise. Circulat. Res.20, Suppl. I, 44–58 (1967).
Brutsaert, D. L., Influence of different fixed heart rates on the adaptation of the cardiac output to muscular exercise. Arch. Int. Physiol.73, 384–386 (1965).
Burgh Daly, de M., Reflex circulatory and respiratory responses to hypoxia. In:F. Dickens andE. Neil: Oxygen in the Animal Organism. (New York 1964).
Cardus, D. andW. Spencer, Recovery time of heart frequency in healthy men its relation to age and physical condition. Arch. Phys. Med.48, 71–77 (1967).
Ceretelli, P. andI. Brambilla, Cinetica dells contrazione di un debito di O2 nell'uomo. Boll. Soz. it al. biol. speriment.34, 679–684 (1958).
Chalmers, J. P., P. I. Korner andS. W. White, Local and reflex factors effecting the distribution of the peripheral blood flow during arterial hypoxia in the rabbit. J. Physiol. (London)192, 537–548 (1967).
Capler, C. K. andW. N. Stainsby, Carbohydrate metabolism in contracting dog skeletal muscle in situ. Amer. J. Physiol.215, 995–1004 (1968).
Cherniak, N. S., G. S. Longobardo, I. Stow andM. Heymann, Dynamics of carbon dioxide stores changes following an alteration in ventilation. J. Appl. Physiol.21, 785–793 (1966).
Clynes, M., Unidirectional rate sensitivity: a biocybernetic law of the reflex and humoral systems as physiological channals of control and communication. Ann. N. Y. Acad. Sci.92, 946–969 (1961).
Cogswell, R. C. andW. J. Browner, Effects of non voluntary electrically stimulated muscular activity on pulse rate, blood pressure and O2 uptake. J. Appl. Physiol.8, 19–21 (1955).
Davies, C., Limitations of the prediction of maximum oxygen intake from cardiac frequency measurements. J. Appl. Physiol.24, 700–706 (1968).
Diamant, B., J. Karlsson andB. Saltin, Muscle tissue lactate after maximal exercise in man. Acta Physiol. Scand.72, 386–384 (1968).
Donald, D. E. andJ. T. Shepherd, Response to exercise in dogs with cardiac denervation. Amer. J. Physiol.205, 393–400 (1963).
Donald, D. E. andJ. T. Shepherd, Initial cardiovascular adjustment to exercise in dogs with chronic cardiac denervation. Amer. J. Physiol.207, 1325–1329 (1964).
Douglas, C. G. andJ. S. Haldane, The regulation of the general circulation rate in man. J. Physiol., London,56, 69–83 (1922).
Ekblom, B. andL. Hermansen, Cardiac output in athletes. J. Appl. Physiol.25, 619–625 (1968).
Ekelund, L. G., Circulatory and respiratory adaptation during prolonged exercise in the supine position. Acta. Physiol. Scand.68, 382–396 (1966).
Ekelund, L. G. andA. Holmgren, Circulatory and respiratory adaptation during long term, non steady state exercise in the sitting position. Acta Physiol. Scand.62, 240–255 (1964).
Ekelund, L. G., A. Holmgren andC. O. Ovenfors, Heart volume during prolonged exercise in the supine and sitting position. Acta Physiol. Scand.70, 88–98 (1967).
Farhi, L. E., Gas stores of the body. Handbook of Physiology, Respiration I (Washingon 1964).
Farhi, L. E. andH. Rahn, Gas stores of the body and the unsteady state. J. Appl. Physiol.7, 472–484 (1955).
Fassbender, D., Der Einfluß von Arbeitszeit und Leistung auf die physische Ermüdung gemessen an der Erholungspulssumme. (Dissertation Universität Köln, 1969).
Goldstone, B. W., Cardiac adaptation to exercise. Pflügers Arch. ges. Physiol.295, 15–34 (1967).
Granit, R., Receptors and sensory perception. New Haven: Yale Univ. Press, 1955).
Grimby, G., N. J. Nilson andB. Saltin, Cardiac output during submaximal exercise in active middle-aged athlets. J. Appl. Physiol.21, 1150–1156 (1966).
Guyton, A. C., Venous return. Handbook of Physiol. Sect.2, Vol. 2, 1099–1133 (1963).
Guyton, A. C., S. M. Ross, O. Carrier andJ. R. Walker, Evidence for tissue oxygen demands as the major factor causing autoregulation, AHA Monogr.8, 60–68 (1964).
Haddy, E. andJ. B. Scott, Metabolically linked vasoactive chemicals in local regulation of blood flow. Physiol. Rev.48, 688–707 (1968).
Heinrich, K. W., H. V. Ulmer andJ. Stegemann, Sauerstoffaufnahme, Pulsfrequenz und Ventilation bei Variation von Tretgeschwindigkeit und Tretkraft bei aerober Ergometerarbeit. Pflügers Arch. ges. Physiol.298, 191–199 (1968).
Henry, F. M., Aerobi coxygen consumption and alactic debt in muscu-lar work. J. Appl. Physiol.3, 427–438 (1951).
Henry, F. M., Lactic and alactic oxygen consumption in moderate exercise of gradet intensity. J. Appl. Physiol.8, 608–614 (1956).
Heymans, C. andE. Neil, Reflexogenic areas of the cardiovascular system. (Boston, Mass., 1958).
Hill, A. V. andJ. V. Howarth, The efect of potassium on the resting metabolism of the frog statorius. Proc. Roy. Soc. B147, 21–43 (1957).
Hirche, Hj., W. K. Raff andD. Gruen, Der extravasale Strömungswiderstand des Skelettmuskels. Pflügers Arch. ges. Physiol.300, R66 (1968).
Hnik, P., O. Hudlicka, J. Kucera andR. Payne, Activation of muscle afferents by non proprioceptive stimuli. Amer. J. Physiol.217, 1451–1457 (1969).
Hollmann, W., Die Höchst- und Dauerleistungsgrenze des Sportlers (München 1963).
Holloszy, J. O., Biochemical adaptations in muscle. Effect of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J. Biol. Chem.242, 2278–2284 (1967).
Holmgren, A., Circulatory changes during muscular exercise in man. Scand. J. Clin. Lab. Invest.8, Suppl. 24 (1956).
Hultmann, E., Physiological role of muscle glycogen in man, with special reference to exercise. Circul. Res.20, Suppl. 1, 99–120 (1967).
Jarisch, A. andF. Gaisboek, Über das Verhalten des Kreislaufes bei der postanämischen Hyperämie. Arch. exp. path. Pharmacol.139, 159–171 (1929).
Jöbsis, F. F., Basic processes in cellular respiration. Handbook of Physiology, Respiration I, (Washington, D. C. 1964).
Kao, F. F., L. Sukhamay, C. Wang andS. Mei, Ventilation and cardiac output in exercise. Circulat. Res.20: Suppl. I, 179–191 (1967).
Karrasch, K. andE. A. Müller, Das Verhalten der Pulsfrequenz in der Erholungsphase nach körperlicher Arbeit. Arbeitsphysiologie14, 369–378 (1951).
Kenner, T., M. Ueda, L. Huntsman andE. O. Attinger, Effects of local and general hypoxia on iliac flow. Angiologica5, 345–363 (1968).
Keul, J., E. Doll andD. Keppler, Zum Stoffwechsel des Skelettmuskels. 1. Mitteilung. Pflügers Arch. ges. Physiol.301, 198–208 (1968).
Khouri, E. M., D. E. Gregg undC. R. Rayford, Effect of exercise on cardiac output, left coronary and myocardial metabolism in the unanesthetized dog. Circul. Res17, 427–437 (1965).
Kjellmer, I., On the competition between metabolic vasodilation and neurogenic vasoconstriction in skeletal muscle. Acta Physiol. Scand.63, 450–459 (1965).
Kjellmer, I., The potassium ion as a vasodilatator during muscle exercise. Acta Physiol. Scand.63, 460–468 (1965).
Kontos, H. A., D. W. Richardson andJ. L. Patterson, Effects of hypercapnia on human forearm blood flow. Amer. J. Physiol.212, 1070–1080 (1967).
Korner, P. I. andS. W. White, Circulatory control in hypoxia by the sympathetic nerve and adrenal medulla. J. Physiol. (London)184, 272–290 (1959).
Korner, P. I., Circulatory adaptation in hypoxia.39, 687–730 (1959).
Krogh, A. andJ. Lindhard, The regulation of respiration and circulation during the initial stages of muscular work. J. Physiol., London47, 112–127 (1913).
Kraus, H., R. Kirsten andJ. Wolff, Die Wirkung von Schwimm- und Lauftraining auf die celluläre Funktion und Struktur des Muskels. Pflügers Arch. ges. Physiol.308, 57–79 (1969).
Lind, A. R. andG. W. McNicol, Cardiovascular responses to holding and carrying weights by hand and by shoulder harness. J. Appl. Physiol.25, 261–267 (1968).
Lind, A. R. andG. W. McNicol, Muscular factors which determine the cardiovascular responses to sustained and rhythmic exercise. Can. Med. Ass.69, 706–713 (1967).
Luft, U. C., Aviation Physiology—The effects of altitude. Handbook of Physiology, Respiration II. (Washington D. C. 1965).
Marsland, W., Heart rate response to submaximal exercise in the standardbred horse. J. Appl. Physiol.24, 98–101 (1968).
Margaria, R., H. T. Edwards andD. B. Dill, The possible mechanism of contracting and paying the oxygen debt and the role of lactic acid in muscular contraction. Amer. J. Physiol.106, 699–712 (1933).
Migone, L., Metabolics aspects of shock, In: Shock, pathogenesis and therapy. (Berlin/Göttingen/Heidelberg 1962).
Monod, H., La validite desmeasures de frequence cardiaque en ergonomie Ergonomics10, 485–537 (1967).
Moor, de J., Individual differences in oxygen debt curves related to mechanical efficiency and sex. J. Appl. Physiol.6, 440–466 (1954).
Müller, E. A., Ein Leistungspulsindex als Maß der Leistungsfähigkeit. Arbeitsphysiologie14, 271–279 (1950).
Müller, E. A., Energieumsatz und Pulsfrequenz bei negativer Muskelarbeit. Arbeitsphysiologie15, 196–202 (1953).
Müller, E. A., Wirkungsgrad und Leistungsfähigkeit bei Arbeit mit den Wadenmuskeln. Int. Z. angew. Physiol.16, 25–39 (1955).
Müller, E. A., Regulation der Pulsfrequenz in der Erholungsphase nach ermüdender Muskelarbeit. Int. Z. angew. Physiol.17, 25–34 (1955).
Müller, E. A., Muskelarbeit und Muskeldurchblutung bei reaktiver Hyperämie. Pflügers Arch. ges. Physiol.265, 429–439 (1958).
Müller, E. A., Die physische Ermüdung. In: Handbuch der gesamten Arbeitsmedizin, Vol. 1. (München 1961).
Müller, E. A., Physiological methods of increasing human physical work capacity. Ergonomics8, 409–424 (1965).
Müller, E. A. andK. Kogi, Die Arbeits-pulsfrequenz als Indikator für langfristige Muskelermüdung. Int. Z. angew. Physiol.20, 493–503 (1965).
Opitz, E., Über akute Hypoxie. Erg. Physiol. exptl. Pharmacol.44, 315–424 (1941).
Optiz, E., Registrierung des Herzzeitvolumens beim Hund nach dem Fick'schen Prinzip. Pflügers Arch. ges. Physiol.250, 56–78 (1948).
Pichotka, J., Der Gesamtorganismus im Sauerstoffmangel. In: Handbuch der Allgemeinen Pathologie, IV/2, 395–453 (1957).
Prampero, D. E. andR. Margaria, Relationship between O2 consumption high energy phosphates and the kinetics of the O2 debt in exercise. Pflügers Arch. ges. Physiol.304, 11–19 (1968).
Piiper, J., E. Prampero andP. Cerretelli, Oxygen debt and high energy phosphates in gastrocnemius muscle of the dog. Amer. J. Physiol.215, 523–531 (1968).
Pugh, L., M. Gill, S. Lahiri, J. S. Milledge, M. Ward andJ. West, Muscular exercise at great altitude. J. Appl. Physiol.19, 431–440 (1964).
Raemmal, L. andG. Stroem, The rate of lactate utilization in man during work and at rest. Acta Physiol. Scand.17, 452–456 (1949).
Rein, H., Die Interferenz der vasomotorischen Regulationen. Klin. Wschr.9, 1485–1489 (1930).
Robinson, B. F., S. T. Epstein, G. Beiser andE. Braunwald, Control of the heart rate by the autonomic nervous system. Studies in man on the interaction between baroreceptor mechanism and exercise. Circul. Res.19, 400–411 (1966).
Richardson, D. W., A. J. Wassermann andJ. L. Patterson, General and regional circulatory responses to change in blood pH and carbon dioxide tension. J. Clin. Invest.40, 31–43 (1961).
Rohmert, W., Ermittlung von Erholungspausen für statische Arbeit des Menschen. Int. Z. angew. Physiol.18, 123–164 (1960).
Rohmert, W., Untersuchungen über Muskelermüdung und Arbeitsgestaltung. (Habilitationsschrift der Techn. Hochschule Aachen 1962).
Rowlands, D. andD. Donald, Sympathetic vasoconstrictive responses during exercise or drug induced vasodilatation. Circul. Res.23, 45–60 (1968).
Rulcker, C., Influence of physical training and short time physical stress on colour fluid loss, pH, adenosine triphosphate and glycogen of gracilis muscle in pigs, an experimental study. Acta vet. Scand. Suppl.7 (1968).
Rushmer, R. F. andO. A. Smith jr., Cardiac control. Physiol. Rev.39, 41–65 (1959).
Saltin, B., A. P. Gagge andJ. A. Stolmijk, Muscle temperature during submaximal exercise in man. J. Appl. Physiol.25, 679–683 (1968).
Scher, A. M. andA. C. Young, Servoanalysis of carotid sinus reflex effects on peripheral resistance. Circul. Res.12, 152–164 (1963).
Schneider, E. G., S. Robinson andJ. L. Newton, Oxygen debt in aerobic work. J. Appl. Physiol.25, 58–62 (1968).
Sjoestrand, T., Volume and distribution of blood and their significance in regulating the circulation. Physiol. Rev.33, 202–228 (1953).
Skinner, N. S. andW. J. Powell, Actions of oxygen and potassium on vascular resistance of dog skeletal muscle. Amer. J. Physiol.212, 533–540 (1967).
Solandt, D. Y., The effect of potassium on the excitability and resting metabolism of frog muscle. J. Physiol. (London)86, 162–170 (1936).
Stegemann, J., Der Einfluß sinusförmiger Druckänderungen im isolierten Karotissinus auf Blutdruck und Pulsfrequenz beim Hund. Verh. Dtsch. Ges. Kreislaufforschg.23, 392–395 (Darmstadt 1957).
Stegemann, J., Zum Mechanismus der Pulsfrequenzeinstellung durch den Stoffwechsel. Mitteilung 1–4. Pflügers Arch. ges. Physiol.276, 481–537 (1963). (4 communications: a, b, c, d).
Stegemann, J., Der Einfluß von Kohlendioxyddrucken auf das interstitielle pH des iosierten Rattendiaphragmas. Pflügers Arch. ges. Physiol.279, 36–49 (1964).
Stegemann, J. andM. Maggio, Die additive Wirkung der Führungsgrößen Hypoxämie und Muskelleistung auf die Regelung des Kreislaufes. Pflügers Arch. ges. Physiol.265, 541–549 (1958).
Stegemann, J. andH. Mueller Buetow, Zur regeltheoretischen Analyse des Blutkreislaufes, 1. Mitteilung. Pflügers Arch. ges. Physiol.287, 249–256 (1966).
Stegemann, J. andK. Geisen, Zur regeltheoretischen Analyse des Blutkreislaufes, 4. Mitteilung. Pfügers Arch. ges. Physiol.287, 276–285 (1966).
Stegemann, J., H. V. Ulmer andD. Boening, Auslösung peripherer neurogener Atmungs- und Kreislaufantriebe durch Erhöhung des CO2 Druckes in größeren Muskelgruppen. Pflügers Arch. ges. Physiol.293, 155–164 (1967).
Stegemann, J. andD. Boening, Die Wirkung erhöhter Metabolit-konzentrationen im Muskel auf die Ventilation. Pflügers Arch. ges. Physiol.294, 214–226 (1967).
Stegemann, J. andU. Tibes, Sinusoidal stimulation of carotid sinus baroreceptors and peripheral blood pressure in dogs. Ann. N. Y. Acad. Sci.156, 787–792 (1969).
Stegemann, J., H. Framing andM. Schiefeling, Der Einfluß einer mehrstündigen Immersion in thermoindifferentem Wasser auf Blutdruck und Pulsfrequenzverhalten des Menschen. Pflügers Arch. ges. Physiol. (in press).
Stenberg, J., B. Ekblom andR. Messin, Hemodynamic response to work at stimulated altitude. J. Appl. Physiol.21, 1589–1594 (1966).
Strauss, E., Die Bedeutung der Druckamplitude und des Herzreflexes für die reflektorische Selbststeuerung des Kreislaufes. Arch. Kreislaufforschg.6, 65–71 (1940).
Suutarinen, T., Cardiovascular response to changes in arterial carbon dioxide tension. Acta Physiol. Scand.67, Suppl. 266 (1966).
Ulmer, H. V., Ein rechnerisches Kriterion zur Bestimmung der Dauerleistungsgrenze. Int. Z. angew. Physiol.27, 299–310 (1969).
Warner, H., The role of peripheral resistance in controlling cardiac output during exercise. Ann. N. Y. Acad. Sci.115, 669–679 (1964).
Welch, H. G. andW. N. Stainsby, Oxygen debt in contracting dog skeletal muscle in situ. Resp. Physiol.3, 229–242 (1967)
Wenzel, H. G., Über die Beziehung zwischen Körperkerntemperatur und Pulsfrequenz des Menschen bei körperlicher Arbeit unter warmen Klimabedingungen. Int. Z. angew. Physiol.26, 43–94 (1968).
Wigertz, O., Dynamics of ventilation and heart rate response to sinusoidal work load in man. J. Appl. Physiol.29, 208–218 (1970).
Wiggers, C. J., Physiology of shock. (New York 1950).
Wildenthal, K., D. Mierzwiak, N. S. Skinner andJ. Mitchell, Potassium induced cardiovascular and ventilatory reflexes from the dog hind limb. Amer. J. Physiol.215, 542–548 (1968).
Winzler, R. J., The respiration of baker's yeast at low oxygen tension. J. Cell. Comp. Physiol.17, 263–276 (1941).
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Stegemann, J., Kenner, T. A theory on heart rate control by muscular metabolic receptors. Archiv für Kreislaufforschung 64, 185–214 (1971). https://doi.org/10.1007/BF02120466
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DOI: https://doi.org/10.1007/BF02120466