Skip to main content
Log in

Quality assurance of iodine-124 produced via the nuclear reaction124Te (d, 2n)124I

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

For more than a year,124I (T=4.15 d) has been produced routinely with a compact cyclotron by irradiation of124TeO2 with 14 MeV deuterons, followed by dry distillation of the iodine radioisotopes formed from irradiated target materials. The following by-products have been measured and compiled in each charge: 13.2-d123I, 60-d125I, 13.0-d126I, 12.4-h130I and 8.02-d131I. The data show that after 45 h decay time, the sum of the activities of these nuclides is less than 5% of the124I activity. Observation of this limit has been required by the Swiss Regulatory Agencies for a PET study of cell proliferation in human brain tumors using [124I] IUdR.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C.B. Wilson, D.E. Snook, B. Dhokia, C.V. Taylor, I.A. Watson, A.A. Lammertsma, R.M. Lambrecht, J. Waxman, T. Jones, A.A. Epenetos,Int. J. Cancer, 47 (1991) 344.

    PubMed  Google Scholar 

  2. M.A. Bakir, J.W. Babich, J.M. Styles, C.J. Dean, S.A. Eccles, R.M. Lambrecht,J. Nucl. Med., 31 (1990) 777.

    Google Scholar 

  3. K.J. Langen, H.H. Coenen, N. Roosen, P. Kling, O. Muzik, H. Herzog, T. Kuwert, G. Stöcklin, L.E. Feinendegen,J. Nucl. Med., 31 (1990) 281.

    PubMed  Google Scholar 

  4. R. Blasberg, U. Roelcke, R. Weinreich, K. v. Ammon, N. Crompton, I. Guenther, E. Knust, B. Beattie, R. Finn, K. Leenders,J. Nucl. Med., in press.

  5. P. Frey, D. Townsend, A. Flattet, R. de Gautard, S. Widgren, A. Jeavons, A. Christin, A. Smith, A. Long, A. Donath,J. Clin. Endocrinol. Metab., 63 (1986) 918.

    PubMed  Google Scholar 

  6. R.M. Lambrecht, M. Sajjad, M.A. Qureshi, S.J. Al-Yanbawi,J. Radioanal. Nucl. Chem., Lett., 127 (1988) 143.

    Google Scholar 

  7. J. Zweit, M.A. Bakir, R.J. Ott, H.L. Sharma, M. Cox, R. Goodall, Proc. IV. Int. Workshop on Targetry and Target Chemistry (R. Weinreich, ed.), Villigen, Switzerland, PSI 1992, 76.

  8. M.L. Firouzbakht, D.J. Schlyer, R.D. Finn, G. Laguzzi, A.P. Wolf,Nucl. Instr. Meth., B 79 (1993) 909.

    Google Scholar 

  9. M.L. Firouzbakht, D.J. Schlyer, A.P. Wolf,J. Lab. Comp. Radiopharm., 35 (1994) 257.

    Google Scholar 

  10. E.J. Knust, H.J. Machulla, K. Dutschka,J. Radioanal. Nucl. Chem., Lett., 144 (1990) 107.

    Google Scholar 

  11. C.F. Williamson, J.P. Boujot, J. Picard, Report CEA-R 3042 (1966).

  12. E.J. Knust, K. Dutschka, unpublished results (1995).

  13. P. Paras, D.R. Hamilton, C. Evans, N.E. Herrera, M.C. Lagunas-Solar,Int. J. Nucl. Biol. Med., 10 (1983) 111.

    Google Scholar 

  14. B. Scholten, Z. Kovács, F. Tárkányi, S.M. Qaim,Appl. Radiat. Isot., 46 (1995) 255.

    Google Scholar 

  15. R. Weinreich, E.J. Knust, Proc. VI. Int. Workshop on Targetry and Target Chemistry, Vancouver (Aug. 1995). To be published in 1996.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weinreich, R., Knust, E.J. Quality assurance of iodine-124 produced via the nuclear reaction124Te (d, 2n)124I. Journal of Radioanalytical and Nuclear Chemistry Letters 213, 253–261 (1996). https://doi.org/10.1007/BF02163571

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02163571

Keywords

Navigation