Skip to main content
SpringerLink
Log in

Glycoproteins of myelin sheaths

  • Minireview
  • Published:
Journal of Molecular Neuroscience Aims and scope Submit manuscript

Abstract

A growing number of glycoproteins have been identified and characterized in myelin and myelin-forming cells. In addition to the major P0 glycoprotein of compact PNS myelin and the myelin-associated glycoprotein (MAG) in the periaxonal membranes of myelin-forming oligodendrocytes and Schwann cells, the list now includes peripheral myelin protein-22 (PMP-22), a 170 kDa glycoprotein associated with PNS myelin and Schwann cells (P170k/SAG), Schwann cell myelin protein (SMP), myelin/oligodendrocyte glycoprotein (MOG), and oligodendrocytemyelin glycoprotein (OMgp). Many of these glycoproteins are members of the immunoglobulin superfamily and express the adhesion-related HNK-1 carbohydrate epitope. This review summarizes recent findings concerning the structure and function of these glycoproteins of myelin sheaths with emphasis on the physiological roles of oligosaccharide moieties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Adelmann M., Wood J., Benzel I., Fiori P., Lassmann H., Matthieu J. M., Gardinier M. V., Dornmair K., and Linington C. (1995) The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat.J. Neuroimmunol. 63, 17–27.

    Article  PubMed  CAS  Google Scholar 

  • Afar D. E., Salzer J. L., Roder J., Braun P. E., and Bell J. C. (1990) Differential phosphorylation of myelin-associated glycoprotein isoforms in cell culture.J. Neurochem. 55, 1418–1426.

    Article  PubMed  CAS  Google Scholar 

  • Agrawal H. C., Noronha A. B., Agrawal D., and Quarles R. H. (1990) The myelin-associated glycoprotein is phosphorylated in the peripheral nervous system.Biochem. Biophys. Res. Commun. 169, 953–958.

    Article  PubMed  CAS  Google Scholar 

  • Amiguet P., Gardinier M. V., Zanetta J. P., and Matthieu J. M. (1992) Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein.J. Neurochem. 58, 1676–1682.

    Article  PubMed  CAS  Google Scholar 

  • Amor S., Groome N., Linington C., Morris M. M., Dornmair K., Gardinier M. V., Matthieu J. M., and Baker D. (1994) Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice.J. Immunol. 153, 4349–4356.

    PubMed  CAS  Google Scholar 

  • Bambrick L. L. and Braun P. E. (1991) Phosphorylation of myelin-associated glycoprotein in cultured oligodendrocytes.Dev. Neurosci. 13, 412–416.

    PubMed  CAS  Google Scholar 

  • Bartoszewicz Z. P., Noronha N. B., Fujita N., Sato S., Bö L., Trapp B. D., and Quarles R. H. (1995) Abnormal expression and glycosylation of the large and small isoforms of myelin-associated glycoprotein in dysmyelinating trembler mutants.J. Neurosci. Res. 41, 27–38.

    Article  PubMed  CAS  Google Scholar 

  • Bartoszewicz Z. P., Lauter C. J., and Quarles R. H. (1996) The myelin-associated glycoprotein of the peripheral nervous system in trembler mutants contains increased α2–3 sialic acid.J. Neurosci. Res. 43, 587–593.

    Article  PubMed  CAS  Google Scholar 

  • Bartsch U., Bandtlow C., Schnell L., Batrsch S., Spillman A., Rubin B., Hillenbrand R., Montag D., Schwab M., and Schachner M. (1995) Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS.Neuron 15, 1375–1381.

    Article  PubMed  CAS  Google Scholar 

  • Bollensen E. and Schachner M. (1987) The peripheral myelin glycoprotein P0 expresses the L2/HNK-1 and L3 carbohydrate structures shared by neural adhesion molecules.Neurosci. Lett. 82, 77–82.

    Article  PubMed  CAS  Google Scholar 

  • Brunden K. R. (1992) Age-dependent changes in the oligosaccharide structure of the major myelin glycoprotein, P0.J. Neurochem. 58, 1659–1666.

    Article  PubMed  CAS  Google Scholar 

  • Brunner C., Lassmann H., Waehneldt T. V., Matthieu J. M., and Linington C. (1989) Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats.J. Neurochem. 52, 296–304.

    Article  PubMed  CAS  Google Scholar 

  • Burger D., Perruisseau G., Simon M., and Steck A. J. (1992a) Comparison of the N-linked oligosaccharide structures of the two major human myelin glycoproteins MAG and P0: assessment and relative occurrence of oligosaccharide structures by serial lectin affinity chromatography of 14C-glycopeptides.J. Neurochem. 58, 845–853.

    Article  PubMed  CAS  Google Scholar 

  • Burger D., Perruisseau G., Simon M., and Steck A. J. (1992b) Comparison of the N-linked oligosaccharide structures of the two major human myelin glycoproteins MAG and P0: assessment of the structures bearing the epitope for HNK-1 and human monoclonal immunoglobulin M found in demyelinating neuropathy.J. Neurochem. 58, 854–861.

    Article  PubMed  CAS  Google Scholar 

  • Burger D., Steck A. J., Bernard C. C., and Kerlero de Rosbo N. (1993) Human myelin/oligodendrocyte glycoprotein: a new member of the L2/HNK-1 family.J. Neurochem. 61, 1822–1827.

    Article  PubMed  CAS  Google Scholar 

  • D’Urso D., Brophy P. J., Staugaitis S. M., Gillespie C. S., Frey A. B., Stempak J. G., and Colman D. R. (1990) Protein zero of peripheral nerve myelin: biosynthesis, membrane insertion, and evidence for homotypic interaction.Neuron 4, 449–460.

    Article  PubMed  CAS  Google Scholar 

  • de Waegh S. M., Lee V. M., and Brady S. T. (1992) Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells.Cell 68, 451–463.

    Article  PubMed  Google Scholar 

  • Dieperink M. E., O’Neill A., Magnoni G., Wollmann R. L., Heinrikson R. L., Zucher N. H., and Stefansson K. (1992) SAG: a Schwann cell membrane glycoprotein.J. Neurosci. 12, 2177–2185.

    PubMed  CAS  Google Scholar 

  • Doherty P. and Walsh F. S. (1994) Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules.Curr. Opin. Neurobiol. 4, 49–55.

    Article  PubMed  CAS  Google Scholar 

  • Dulac C., Cameron-Curry P., Ziller C., and Le Douarin N. M. (1988) A surface protein expressed by avian myelinating and nonmyelinating Schwann cells but not by satellite or enteric glial cells.Neuron 1, 211–220.

    Article  PubMed  CAS  Google Scholar 

  • Dulac C., Tropak M. B., Cameron-Curry P., Rossier J., Marshak D. R., Roder J., and Le Douarin N. M. (1992) Molecular characterization of the Schwann cell myelin protein, SMP: structural similarities within the immunoglobulin superfamily.Neuron 8, 323–334.

    Article  PubMed  CAS  Google Scholar 

  • Dyer C. A. and Matthieu J. M. (1994) Antibodies to myelin/oligodendrocyte-specific protein and myelin/oligodendrocyte glycoprotein signal distinct changes in the organization of cultured oligodendroglial membrane sheets.J. Neurochem. 62, 777–787.

    Article  PubMed  CAS  Google Scholar 

  • Edwards A. M., Arquint M., Braun P. E., Roder J. C., Dunn R. J., Pawson T., and Bell J. C. (1988) Myelin-associated glycoprotein, a cell adhesion molecule of oligodendrocytes, is phosphorylated in brain.Mol. Cell Biol. 8, 2655–2658.

    PubMed  CAS  Google Scholar 

  • Edwards A. M., Braun P. E., and Bell J. C. (1989) Phosphorylation of myelin-associated glycoprotein in vivo and in vitro occurs only in the cytoplasmic domain of the large isoform.J. Neurochem. 52, 317–320.

    Article  PubMed  CAS  Google Scholar 

  • Eichberg J. and Iyer S. (1996) Minireview: phosphorylation of myelin proteins: recent advances.Neurochem. Res. 21, 527–535.

    Article  PubMed  CAS  Google Scholar 

  • Fahrig T., Landa C., Pesheva P., Kuhn K., and Schachner M. (1987) Characterization of binding properties of the myelin-associated glycoprotein to extracellular matrix constituents.EMBO J. 6, 2875–2883.

    PubMed  CAS  Google Scholar 

  • Fahrig T., Probstmeier R., Spiess E., Meyer F. A., Kirchhoff F., Drescher B., and Schachner M. (1993) Functional topography of the myelin-associated glycoprotein. I. Mapping of domains by electron microscopy.Eur. J. Neurosci. 5, 1118–1126.

    Article  PubMed  CAS  Google Scholar 

  • Field M. C., Wing D. R., Dwek R. A., Rademacher T. W., Schmitz B., Bollensen E., and Schachner M. (1992) Detection of multisulphated N-linked glycans in the L2/HNK-1 carbohydrate epitope expressing neural adhesion molecule P0.J. Neurochem. 58, 993–1000.

    Article  PubMed  CAS  Google Scholar 

  • Filbin M. T., Walsh F. S., Trapp B. D., Pizzey J. A., and Tennekoon G. I. (1990) Role of myelin Po protein as a homophilic adhesion molecule.Nature 344, 871,872.

    Article  PubMed  CAS  Google Scholar 

  • Filbin M. T. and Tennekoon G. I. (1991) The role of complex carbohydrates in adhesion of the myelin protein, P0.Neuron 7, 845–855.

    Article  PubMed  CAS  Google Scholar 

  • Filbin M. T. and Tennekoon G. I. (1993) Homophilic adhesion of the myelin Po protein requires glycosylation of both molecules in the homophilic pair.J. Cell. Biol. 122, 451–459.

    Article  PubMed  CAS  Google Scholar 

  • Fruttiger M., Montag D., Schachner M., and Martini R. (1995) Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity.Eur. J. Neurosci. 7, 511–515.

    Article  PubMed  CAS  Google Scholar 

  • Gardinier M. V., Amiguet P., Linington C., and Matthieu J. M. (1992) Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily.J. Neurosci. Res. 33, 177–187.

    Article  PubMed  CAS  Google Scholar 

  • Giese K. P., Martini R., Lemke G., Soriano P., and Schachner M. (1992) Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons.Cell 71, 565–576.

    Article  PubMed  CAS  Google Scholar 

  • Griffith L. S., Schmitz B., and Schachner M. (1992) L2/HNK-1 carbohydrate and protein-protein interactions mediate the homophilic binding of the neural adhesion molecule P0.J. Neurosci. Res. 33, 639–648.

    Article  PubMed  CAS  Google Scholar 

  • Hammer J. A., O’Shannessy D. J., De L. M., Gould R., Zand D., Daune G., and Quarles R. H. (1993) Immunoreactivity of PMP-22, P0, and other 19 to 28 kDa glycoproteins in peripheral nerve myelin of mammals and fish with HNK1 and related antibodies.J. Neurosci. Res. 35, 546–558.

    Article  PubMed  CAS  Google Scholar 

  • Hays A. P., Latov N., Takatsu M., and Sherman W. H. (1987) Experimental demyelination of nerve induced by serum of patients with neuropathy and an anti-MAG IgM M-protein.Neurology 37, 242–256.

    PubMed  CAS  Google Scholar 

  • Hilton A. A., Slavin A. J., Hilton D. J., and Bernard C. C. (1995) Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein.J. Neurochem. 65, 309–318.

    Article  PubMed  CAS  Google Scholar 

  • Jaramillo M. L., Afar D. E., Almazan G., and Bell J. C. (1994) Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules.J. Biol. Chem. 269, 27,240–27,245.

    CAS  Google Scholar 

  • Johns T. G., Kerlero de Rosbo N., Menon K. K., Abo S., Gonzales M. F., and Bernard C. C. (1995) Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis.J. Immunol. 154, 5536–5541.

    PubMed  CAS  Google Scholar 

  • Johnson P. W., Abramow N. W., Seilheimer B., Sadoul R., Tropak M. B., Arquint M., Dunn R. J., Schachner M., and Roder J. C. (1989) Recombinant myelin-associated glycoprotein confers neural adhesion and neurite outgrowth function.Neuron 3, 377–385.

    Article  PubMed  CAS  Google Scholar 

  • Kelm S., Pelz A., Schauer R., Filbin M. T., Tang S., de B. M., Schnaar R. L., Mahoney J. A., Hartnell A., Bradfield P., et al. (1994) Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily.Curr. Biol. 4, 965–792.

    Article  PubMed  CAS  Google Scholar 

  • Kerlero de Rosbo N., Milo R., Lees M. B., Burger D., Bernard C. C., and Ben N. A. (1993) Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein.J. Clin. Invest. 92, 2602–2608.

    Article  PubMed  CAS  Google Scholar 

  • Kirchhoff F., Hofer H. W., and Schachner M. (1993) Myelin-associated glycoprotein is phosphorylated by protein kinase C.J. Neurosci. Res. 36, 368–381.

    Article  PubMed  CAS  Google Scholar 

  • Kitamura K., Suzuki M., and Uyemura K. (1976) Purification and partial characterization of two glycoproteins in bovine peripheral nerve myelin membrane.Biochim. Biophys. Acta 455, 806–816.

    Article  PubMed  CAS  Google Scholar 

  • Li C., Tropak M. B., Gerlai R., Clapoff S., Abramow N. W., Trapp B., Peterson A., and Roder J. (1994) Myelination in the absence of myelin-associated glycoprotein.Nature 369, 747–750.

    Article  PubMed  CAS  Google Scholar 

  • Linington C., Webb M., and Woodhams P. (1984) A novel myelin associated glycoprotein defined by a mouse monoclonal antibody.J. Neuroimmunol. 6, 387–396.

    Article  Google Scholar 

  • Low K., Orberger G., Schmitz B., Martini R., and Schachner M. (1994) The L2/HNK-1 carbohydrate is carried by the myelin associated glycoprotein and sulphated glucuronyl glycolipids in muscle but not cutaneous nerves of adult mice.Eur. J. Neurosci. 6, 1773–1781.

    Article  PubMed  CAS  Google Scholar 

  • Martini R., Schachner M., and Brushart T. M. (1994) The L2/HNK-1 carbohydrate is preferentially expressed by previously motor axon-associated Schwann cells in reinnervated peripheral nerves.J. Neurosci. 14, 7180–7191.

    PubMed  CAS  Google Scholar 

  • Martini R., Mohajeri M. H., Kasper S., Giese K. P., and Schachner M. (1995) Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin.J. Neurosci. 15, 4488–4495.

    PubMed  CAS  Google Scholar 

  • Matthieu J. M. and Amiguet P. (1990) Myelin/oligodendrocyte glycoprotein expression during development in normal and myelin-deficient mice.Dev. Neurosci. 12, 293–302.

    PubMed  CAS  Google Scholar 

  • McKerracher L., David S., Jackson D. L., Kottis V., Dunn R. J., and Braun P. E. (1994) Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth.Neuron 13, 805–811.

    Article  PubMed  CAS  Google Scholar 

  • Mendel I., Kerlero de Rosbo N., and Ben-Nun A. (1995) A myelin/oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells.Eur. J. Immunol. 25, 1951–1959.

    Article  PubMed  CAS  Google Scholar 

  • Meyer-Franke A., Tropak M. B., Roder J. C., Fischer P., Beyreuther K., Probstmeier R., and Schachner M. (1995) Functional topography of myelin-associated glycoprotein. II. Mapping of domains on molecular fragments.J. Neurosci. Res. 41, 311–323.

    Article  PubMed  CAS  Google Scholar 

  • Mikol D. D. and Stefansson K. (1988) A phosphatidylinositol-linked peanut agglutinin-binding glycoprotein in central nervous system myelin and on oligodendrocytes.J. Cell Biol. 106, 1273–1279.

    Article  PubMed  CAS  Google Scholar 

  • Mikol D. D., Gulcher J. R., and Sefansson K. (1990a) The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate.J. Cell Biol. 110, 471–479.

    Article  PubMed  CAS  Google Scholar 

  • Mikol D. D., Alexakos M. J., Bayley C. A., Lemons R. S., Le B. M., and Stefansson K. (1990b) Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein.J. Cell Biol. 111, 2673–2679.

    Article  PubMed  CAS  Google Scholar 

  • Mikol D. D., Rongnoparut P., Allwardt B. A., Marton L. S., and Stefansson K. (1993) The oligodendrocyte-myelin glycoprotein of mouse: primary structure and gene structure.Genomics 17, 604–610.

    Article  PubMed  CAS  Google Scholar 

  • Montag D., Giese K. P., Bartsch U., Martini R., Lang Y., Bluthmann H., Karthigasan J., Kirschner D. A., Wintergerst E. S., Nave K. A., et al. (1994) Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin.Neuron 13, 229–246.

    Article  PubMed  CAS  Google Scholar 

  • Morell P., Quarles R.H., and Norton W.T. (1994) Myelin formation structure and biochemistry, inBasic Neurochemistry: Molecular, Cellular and Basic Aspects (Siegel G. J., et al., eds.), Raven, New York, pp. 117–143.

    Google Scholar 

  • Mukhopadhyay G., Doherty P., Walsh F. S., Crocker P. R., and Filbin M. T. (1994) A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration.Neuron 13, 757–767.

    Article  PubMed  CAS  Google Scholar 

  • Needham L. K. and Schnaar R. L. (1993) Carbohydrate recognition in the peripheral nervous system: a calcium-dependent membrane binding site for HNK-1 reactive glycolipids potentially involved in Schwann cell adhesion.J. Cell Biol. 121, 397–408.

    Article  PubMed  CAS  Google Scholar 

  • Owens G. C. and Boyd C. J. (1991) Expressing antisense P0 RNA in Schwann cells perturbs myelination.Development 112, 639–649.

    PubMed  CAS  Google Scholar 

  • Pareek S., Suter U., Snipes G. J., Welcher A. A., Shooter E. M., and Murphy R. A. (1993) Detection and processing of peripheral myelin protein PMP22 in cultured Schwann cells.J. Biol. Chem. 268, 10,372–10,379.

    CAS  Google Scholar 

  • Pedraza L., Spagnol G., Latov N., and Salzer J. L. (1995) Biosynthesis and regulation of expression of the HNK-1 epitope on myelin-associated glycoprotein in a transfected cell model system.J. Neurosci. Res. 40, 716–727.

    Article  PubMed  CAS  Google Scholar 

  • Pham-Dinh D., Mattei M. G., Nussbaum J. L., Roussel G., Pontarotti P., Roeckel N., Mather I. H., Artzt K., Lindahl K. F., and Dautigny A. (1993) Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex.Proc. Natl. Acad. Sci. USA 90, 7990–7994.

    Article  PubMed  CAS  Google Scholar 

  • Pham-Dinh D., Allinquant B., Ruberg M., Dellagaspera B., Nussbaum J. L., and Dautigny A. (1994) Characterization and expression of the cDNA coding for the human myelin/oligodendrocyte glycoprotein.J. Neurochem. 63, 2353–2356.

    Article  PubMed  CAS  Google Scholar 

  • Poltorak M., Sadoul R., Keilhauer G., Landa C., Fahrig T., and Schachner M. (1987) Myelin-associated glycoprotein, a member of the L2/HNK-1 family of neural cell adhesion molecules, is involved in neuron-oligodendrocyte and oligodendrocyte-oligodendrocyte interaction.J. Cell Biol. 105, 1893–1899.

    Article  PubMed  CAS  Google Scholar 

  • Powell L. D. and Varki A. (1995) I-type lectins.J. Biol. Chem. 270, 14,243–14,246.

    CAS  Google Scholar 

  • Probstmeier R., Fahrig T., Spiess E., and Schachner M. (1992) Interactions of the neural cell adhesion molecule and the myelin-associated glycoprotein with collagen type I: involvement in fibrillogenesis.J. Cell Biol. 116, 1063–1070.

    Article  PubMed  CAS  Google Scholar 

  • Quarles R. H. (1989) Glycoproteins of myelin and myelin-forming cells, inNeurobiology of Glycoconjugates (Margolis R. U. and Margolis R. K., eds.), Plenum, New York, pp. 243–275.

    Google Scholar 

  • Quarles R., Colman D., Salzer J., and Trapp B. (1992) Myelin-associated glycoprotein: structure-function relationships and involvement in neurological diseases, inMyelin: Biology and Chemistry (Martenson R., ed.), CRC, Boca Raton, FL, pp. 4413–4448.

    Google Scholar 

  • Rodriguez M. and Scheithauer B. (1994) Ultrastructure of multiple sclerosis.Ultrastruct. Pathol. 18, 3–13.

    PubMed  CAS  Google Scholar 

  • Sadoul R., Fahrig T., Bartsch U., and Schachner M. (1990) Binding properties of liposomes containing the myelin-associated glycoprotein MAG to neural cell cultures.J. Neurosci. Res. 25, 1–13.

    Article  PubMed  CAS  Google Scholar 

  • Schneider-Schaulies J., von Brunn K. A., and Schachner M. (1990) Recombinant peripheral myelin protein Po confers both adhesion and neurite outgrowth-promoting properties.J. Neurosci. Res. 27, 286–297.

    Article  PubMed  CAS  Google Scholar 

  • Schwab M. E., Kapfhammer J. P., and Bandtlow C. E. (1993) Inhibitors of neurite growth.Ann. Rev. Neurosci. 16, 565–595.

    Article  PubMed  CAS  Google Scholar 

  • Scolding N. J., Frith S., Linington C., Morgan B. P., Campbell A. K., Compston D. A., Schluesener H. J., Sobel R. A., Linington C., and Weiner H. L. (1989) Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation.J. Neuroimmunol. 22, 169–176.

    Article  PubMed  CAS  Google Scholar 

  • Shuman S., Hardy M., and Pleasure D. (1983) Peripheral nervous system myelin and Schwann cell glycoproteins: identification by lectin binding and partial purification of a peripheral nervous system myelin-specific 170,000 molecular weight glycoprotein.J. Neurochem. 41, 1277–1285.

    Article  PubMed  CAS  Google Scholar 

  • Shuman S., Hardy M., and Pleasure D. (1986) Immunochemical characterization of peripheral nervous system myelin 170,000-Mr glycoprotein.J. Neurochem. 47, 811–818.

    Article  PubMed  CAS  Google Scholar 

  • Snipes G. J., Suter U., and Shooter E. M. (1993) Human peripheral myelin protein-22 carries the L2/HNK-1 carbohydrate adhesion epitope.J. Neurochem. 61, 1961–1964.

    Article  PubMed  CAS  Google Scholar 

  • Snipes G. J. and Suter U. (1995) Molecular basis of common hereditary motor and sensory neuropathies in humans and in mouse models.Brain Pathol. 5, 233–247.

    PubMed  CAS  Google Scholar 

  • Sun J., Link H., Olsson T., Xiao B. G., Andersson G., Ekre H. P., Linington C., and Diener P. (1991) T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.J. Immunol. 146, 1490–1495.

    PubMed  CAS  Google Scholar 

  • Suter U. and Snipes G. J. (1995) Peripheral myelin protein 22: facts and hypotheses.J. Neurosci. Res. 40, 145–151.

    Article  PubMed  CAS  Google Scholar 

  • Tatum A. H. (1993) Experimental paraprotein neuropathy, demyelination by passive transfer of human IgM anti-myelin-associated glycoprotein.Ann. Neurol. 33, 502–506.

    Article  PubMed  CAS  Google Scholar 

  • Umemori H., Sato S., Yagi T., Aizawa S., and Yamamoto T. (1994) Initial events of myelination involve Fyn tyrosine kinase signalling.Nature 367, 572–576.

    Article  PubMed  CAS  Google Scholar 

  • Uyemura K., Kitamura K., and Miura M. (1992). Structure and molecular biology of P0 glycoprotein, inMyelin: Chemistry and Biology (Martenson, R. E., ed.), CRC, Boca Raton, FL, pp. 481–508.

    Google Scholar 

  • Viskochil D., Cawthon R., O’Connell P., Xu G. F., Stevens J., Culver M., Carey J., and White R. (1991) The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene.Mol. Cell. Biol. 11, 906–912.

    PubMed  CAS  Google Scholar 

  • Wells C. A., Saavedra R. A., Inouye H., and Kirschner D. A. (1993) Myelin P0-glycoprotein: predicted structure and interactions of extracellular domain.J. Neurochem. 61, 1987–1995.

    Article  PubMed  CAS  Google Scholar 

  • Willison H. J., Trapp B. D., Bacher J. D., Dalakas M. C., Griffin J. W., and Quarles R. H. (1988) Demyelination induced by intraneural injection of human antimyelin-associated glycoprotein antibodies.Muscle and Nerve 11, 1169–1176.

    Article  PubMed  CAS  Google Scholar 

  • Xiao B. G., Linington C., and Link H. (1991) Antibodies to myelin-oligodendrocyte glycoprotein in cerebrospinal fluid from patients with multiple sclerosis and controls.J. Neuroimmunol. 31, 91–96.

    Article  PubMed  CAS  Google Scholar 

  • Yamawaki M., Vasquez A., Ben Younes A., Yoshino H., Kanda T., Ariga T., Baumann N., and Yu R. K. (1996) Sensitization of Lewis rats with sulfogucuronosyl paragloboside; Electrophysiological and immunological studies of an animal model of peripheral neuropathy.J. Neurosci. Res. 44, 58–65.

    Article  PubMed  CAS  Google Scholar 

  • Yang L. J., Zeller C. B., Shaper N. L., Kiso M., Hasegawa A., Shapiro R. E., and Schnaar R. L. (1996) Gangliosides are neuronal ligands for myelin-associated glycoprotein.Proc. Natl. Acad. Sci. USA 93, 814–818.

    Article  PubMed  CAS  Google Scholar 

  • Yazaki T., Miura M., Asou H., Kitamura K., Toya S., and Keiichi U. (1992) Glycopeptide of P0 protein inhibits homophilic cell adhesion: competition assay with transformants and peptides.FEBS Lett. 307, 361–366.

    Article  PubMed  CAS  Google Scholar 

  • Yim S. H., Toda K., Goda S., and Quarles R. H. (1995) Comparison of the phosphorylation of myelin-associated glycoprotein in cultured oligodendrocytes and Schwann cells.J. Mol. Neurosci. 6, 63–74.

    PubMed  CAS  Google Scholar 

  • Zhang S. M., Marsh R., Ratner N., and Brackenbury R. (1995) Myelin glycoprotein P0 is expressed at early stages of chicken and rat embryogenesis.J. Neurosci. Res. 40, 241–250.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Myelin and Brain Development Section, Laboratory of Molecular and Cellular Neurobiology, NINDS, NIH, 20892, Bethesda, MD

    Richard H. Quarles

Authors
  1. Richard H. Quarles
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Quarles, R.H. Glycoproteins of myelin sheaths. J Mol Neurosci 8, 1–12 (1997). https://doi.org/10.1007/BF02736858

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02736858

Index Entries

Search

Navigation