Summary
As there is only little information on pregnancy complicated by hereditary spherocytosis, we report on 8 patients with this disorder who had a total of 19 pregnancies. 10 pregnancies occurred in patients before splenectomy, and 9 occurred after splenectomy. There were 13 term births, 4 spontaneous abortions and 2 therapeutic abortions. Of the 19 pregnancies, 8 were complicated by anemia and all were in patients without splenectomy. A hemolytic crisis was encountered in 6 pregnancies, and persistent anemia occurred in 2. Transfusion was required in 4 pregnancies. It would appear that pregnancy may precipitate hemolytic anemia but maternal morbidity and fetal outcome seem more favorable after splenectomy than before splenectomy.
Similar content being viewed by others
References
Dacie J (1985) Hereditary haemolytic anaemias. In: Dacie J (ed) The Haemolytic Anaemias, Vol. 1, Part 1. Churchill Livingstone, Edinburgh, p 142
Ho-Yen DO (1984) Hereditary spherocytosis presenting in pregnancy. Acta Haematol 72:29–33
Ho-Yen DO, Clark DM, Thomson MAR, Brown RA, Goodall HB (1980) In vitro autohaemolysis during pregnancy. Acta Haematol 63:301–304
Kohler HG, Meynell MJ, Cooke WT (1960) Spherotic anaemia, complicated by megaloblastic anaemia of pregnancy. Br Med J I:779–781
Komninos ZD, Minogne WF, Sarvajic-Dottor J (1965) Folic acid deficiency in hereditary spherocytosis. Failure of response to massive parenteral doses of cyanocobalamin. Arch Int Med 115:663–666
Maberry MC, Mason RA, Cunningham FG, Pritchard JA (1992) Pregnancy complicated by hereditary spherocytosis. Obstet Gynecol 79:735–738
Magid MS, Perlin M, Gottfried EL (1982) Increased erythrocyte osmotic fragility in pregnancy. Am J Obstet Gynecol 144:910–914
Mandal AK, Singh T, Ahuja P (1985) Pregnancy in pre- and postsplenectomy cases of hereditary spherocytosis. Acta Haematol 73:187 (letter)
McElin TW, Mussey RD, Watkins CH (1950) Splenectomy during pregnancy, with a report of 5 cases and review of the literature. Am J Obstet Gynecol 59:1036–1044
Mintz U, Moohr JW, Ultmann JE (1977) Hemolytic anemias during pregnancy and the reproductive years. J Reprod Med 19:243–253
Moore A, Sherman MM, Strongin MJ (1976) Hereditary spherocytosis with hemolytic crisis during pregnancy. Treatment by splenectomy. Obstet Gynecol 47:19s-21s
Robertson EG (1968) Increased erythrocyte fragility in association with osmotic changes in pregnancy serum. J Reprod Fertil 16:323–324
Rutkow IM (1981) Twenty years of splenectomy for hereditary spherocytosis. Arch Surg 116:306–308
Ventura CS (1982) Hereditary spherocytosis with hemolytic crisis during pregnancy. Aust N Z Obstet Gynaecol 22:50–53
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pajor, A., Lehoczky, D. & Szakács, Z. Pregnancy and hereditary spherocytosis. Arch Gynecol Obstet 253, 37–42 (1993). https://doi.org/10.1007/BF02770632
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02770632