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D-lactate dehydrogenase

Substrate specificity and use as a catalyst in the synthesis of homochiral 2-hydroxy acids

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Abstract

This note compares the substrate specifity of D-lactate dehydrogenase (D-LDH, EC 1.1.1.28) to that of L-lactate dehydrogenase (L-LDH, EC 1.1.1.27), illustrates three procedures that use D-LDH in synthesis and two methods for recycling NADH, and provides experimental details illustrating the use of D-LDH in organic synthesis.

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Authors and Affiliations

  1. Department of Chemistry, Harvard University, 02138, Cambridge, MA

    Ethan S. Simon, Raymond Plante & George M. Whitesides

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  1. Ethan S. Simon
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  2. Raymond Plante
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  3. George M. Whitesides
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Simon, E.S., Plante, R. & Whitesides, G.M. D-lactate dehydrogenase. Appl Biochem Biotechnol 22, 169–179 (1989). https://doi.org/10.1007/BF02921743

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  • DOI: https://doi.org/10.1007/BF02921743

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