Abstract
Non digestible dietary carbohydrates have been reported to modify lipaemia and post-prandial glycaemia and insulinaemia. The aim of this study was to investigate the effect of a non-digestible gluco-oligosaccharides (GOS) diet on glucose, insulin, triglycerides and free fatty acid blood levels and glucose sensitivity in high fat diet fed mice (a high fat diet composed of 45% fat, 35% carbohydrate and 20% protein). Female C57Bl6/J mice were divided into two groups fed a high fat diet (HF) for 20 weeks supplemented or not with 1.5 g/kg/day of GOS (HF-GOS). The GOS supplementation did not change body weight nor fat pad mass, nor any of the blood parameters measured (glucose, insulin, leptin, triglycerides, and free fatty acids). However, mice which received the GOS supplemented diet showed an increased glucose utilization after a 1 g/kg load of glucose compared with the mice fed the high fat diet alone. Our results suggest a role for non-digestible GOS in the regulation of carbohydrate metabolism.
Resumen
Los carbohidratos no digeribles presentes en los alimentos pueden modificar la lipemia y la glucemia e insulinemia post-prandiales. Se examina en este trabjo el efecto de la suplementación con gluco-oligosacáridos (GOS) no digeribles sobre los niveles en sangre de glucosa, insulina, triglicéridos y ácidos grasos libres, y sobre la tolerancia a la glucosa en ratones sometidos a una dieta rica en grasas (45% grasa, 35% glúcidos y 20% proteínas). Ratones hembra C57Bl6/J alimentados con dieta grasa (DG) durante 20 semanas se repartieron en dos grupos, según recibieran o no suplemento de GOS (1.5 g/kg/día). La suplementación con GOS no modificó el peso corporal, masa grasa ni los niveles circulantes de glucosa, insulina, leptina, triglicéridos, y ácidos grasos libres. Sin embargo, la utilización de glucosa tras sobrecarga del azúcar es superior en los ratones tratados con GOS respecto de los controles sometidos solo a dieta grasa. Estos resultados sugieren un posible papel para los GOS no digeribles en la regulación del metabolismo glucídico.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Daubioul, C. A., Taper, H. S., De Wispelaere L. D. and Delzenne, N. M. (2000):J. Nutr.,130, 1314–1319.
Delzenne, N. M. (2003):Proc. Nutr. Soc.,62(1), 177–182.
Delzenne, N. M. and Kok, N. N. (1999):J. Nutr.,129, 1467S-1470S.
Djouzi, Z. andrieux, C., Pelenc, V., Somarriba, S., Popot, F., Paul, F., Monsan, P. and Szylit, O. (1995):J. Appl. Bacteriol.,79, 117–127.
Fiordaliso, M., Kok, N. N., Desager, J. P., Goethals, F., Deboyser, D., Roberfroid, M. and Delzenne, N. M. (1995):Lipids,30(2), 163–167.
Flickinger, E. A., Wolf, B. W., Garleb, K. A., Chow, J., Leyer, G. J., Johns, P. W. and Fahey Jr, G. C. (2000):J. Nutr.,130, 1267–1273.
Gibson, G. R. and Roberfroid, M. R. (1995):J. Nutr.,125, 1401–1412.
Kok, N. N., Morgan, L. M., Williams, C. M., Roberfroid, M. B., Thissen J-P. and Delzenne, N. M. (1998):J. Nutr.,128, 1099–1103.
Kok, N. N., Taper, H. S. and Delzenne, N.M. (1998):J. Appl. Toxicol.,18(1), 47–53.
Remaud-Simeon, M., Willemot, R. M., Sarçabal, P., Potocki de Montalk, G. and Monsan, P. (2000):J. Mol. Catal. B. Enzymatic.,10, 117–128.
Roberfroid, M. (1993):CRC Crit. Rev. Food Sci. Nutr.,33, 103–148.
Roberfroid, M. B. and Delzenne, N. M. (1998):Annu. Rev. Nutr.,18, 117–143.
Valette, P., Pelenc, V., Djouzi, Z. andrieux, C., Paul, F., Monsan, P. and Szylit, O. (1993):J. Sci. Food Agric.,62, 121–127.
Williams, C. M. and Jackson, K. G. (2002):Br. J. Nutr.,87, Suppl 2, 261–264.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Boucher, J., Daviaud, D., Siméon-Remaud, M. et al. Effect of non-digestible gluco-oligosaccharides on glucose sensitivity in high fat diet fed mice. J. Physiol. Biochem. 59, 169–173 (2003). https://doi.org/10.1007/BF03179912
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03179912