Abstract
The ethanol extracts ofOpuntia ficus-indica fructus (EEOF) andOpuntia ficus-indica stem (EEOS) were prepared and used to evaluate the pharmacological effects of cactus. Both the extracts inhibited the writhing syndrome induced by acetic acid, indicating that they contains analgesic effect. The oral administrations of EEOF and EEOS suppressed carrageenan-induced rat paw edema and also showed potent inhibition in the leukocyte migration of CMC-pouch model in rats. Moreover, the extracts suppressed the release of β-glucuronidase, a lysosomal enzyme in rat neutrophils. It was also noted that the extracts showed the protective effect on gastric mucosal layers. From the results it is suggested that the cactus extracts contain anti-inflammatory action having protective effect against gastric lesions.
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References Cited
Ahmad, A., Davies, J., Randall, S. and Skinner G. R., Antiviral properties of extract ofOpuntia streptacantha.Antiviral Res., 30, 75–85 (1996).
Brittinger, C., Hirrschhorn, R., Douglas, S. D. and Weissmann, G., Studies on lysosomes. XI. Characterization of hydrolase-rich fraction from human leuoocytes.J. Cell Biology., 37, 394–411 (1968).
Cohn, E. A. and Hirsh, J. C., The influence of phagocytosis on the intracellular distribution of granule-associated components of polymorphonuclear leucocytes.J. Exp. Med., 112, 1015 (1950).
Di Rosa, M., Giroud, J. P. and Willoughby, D. A., Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageen-in and turpentine.J. Pathol, 104, 15–29 (1971).
Ghansah, E., Kopsombut, P., Malque, M. A. and Brossi, A., The effects of mescaline and some of its analogs on cholinergic neuromuscular transmission.Neuropharmacology, 32, 169–174 (1993).
Ibanez-Camacho R. and Roman-Ramos R., Hypoglycemic effect of Opuntia cactus.Arch. Invest. Med (Mex)., 10, 223–230 (1979).
Koster, R., Anderson, M. and De Beer, E. J., Acetic acid for analgesic screening.Fed. Proc., 18, 412 (1959).
Lovvry, O. H., Rosebrough, N. J., Farr, A. L. and Radall, R. J., Protein measurement with the folin reagents.J. Biol. Chem., 193, 265–275 (1985).
Mizui, T. and Doteuchi, M., Effects of polyamines on acidified ethanol-induced gastric lesions in rats.Jpn. J. Pharmacol., 33, 939–945 (1983).
Sedgwick, A. D., Sin, Y. M., Edwards, J. C. W. and Willoughby, D. A., Increased inflammatory reactivity in newly formed lining tissue.J. Pathol., 141, 483–496 (1983).
Trejo-Gonzalez A, Gabriel-Ortiz G, Puebla-Perez A. M., Huizar-Contreras M. D, Munguia-Mazarigos M. R. and Mejia-Arreguins C. E., A purified extract from prickly pear cactus (Opuntia fulginosa) controls experimentally induced diabetes in rats.J. Ethanopharmacol., 55, 27–33 (1996).
Vane, J. and Botting, R., Inflammation and mechanism of action of antiinflammatory drugs.FASEB J., 1, 89–96 (1987).
Vineger, R., Truax, J. F. and Selph, J. L., Quantitative studies of the pathway to acute carrageenin inflammation.Fed. Proc., 35, 2447–2456 (1976).
Vineger, R., Truax, J. F., Selph, J. L. and Vowelker, F. A., Pathway of onset, development and decay of carrageenin pleurisy in the rat.Fed. Proc., 41, 2588–2595 (1982).
Wedmore, C. V. and Williams, T. J., Control of vascular permeability by polymorphonuclear leucocyte in inflammation.Nature, 289, 646–650 (1981).
Winter, C. A., Riskey, E. A. and Nuss, G. W., Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drug.Pro. Soc. Exp. Med., 111, 544–547 (1962).
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Park, EH., Kahng, JH. & Paek, EA. Studies on the pharmacological actions of cactus: Identification of its anti-inflammatory effect. Arch. Pharm. Res. 21, 30–34 (1998). https://doi.org/10.1007/BF03216749
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DOI: https://doi.org/10.1007/BF03216749