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Syntheses and antibacterial studies of some 2-[5-(Aryl)-[1,3,4]oxadiazole-2-ylsulfanyl] alkanoic Acids

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Abstract

Some new 2-[5-(aryl)-[1,3,4]oxadiazole-2-ylsulfanyl]alkanoic acids were synthesized and studied for their antibacterial activity. These compounds were prepared from aromatic carboxylic acid hydrazides. Aromatic carboxylic acid hydrazides 1 on refluxing with carbon disulfide and methanolic potassium hydroxide and then on subsequent acidification with hydrochloric acid furnish 5-aryl-1,3,4-oxadiazole-2-thiones 2. 2-Chloro alkanoic acids react with 2 in alkaline media and on acidification yield the title compounds 3. These compounds were characterised by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and their minimum inhibitory concentration (MIC) were determined.

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Authors and Affiliations

  1. JCDM College of Pharmacy, Sirsa-125 055, Haryana, India

    N. Jain

  2. Delhi Institute of Pharmaceutical Science and Research, New Delhi, India

    D. P. Pathak

  3. Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya Sagar, 470 003, M.P., India

    P. Mishra

  4. Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125 001, Haryana, India

    S. Jain

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  1. N. Jain
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  2. D. P. Pathak
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  3. P. Mishra
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  4. S. Jain
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Correspondence to N. Jain.

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Jain, N., Pathak, D.P., Mishra, P. et al. Syntheses and antibacterial studies of some 2-[5-(Aryl)-[1,3,4]oxadiazole-2-ylsulfanyl] alkanoic Acids. JICS 6, 77–81 (2009). https://doi.org/10.1007/BF03246504

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  • DOI: https://doi.org/10.1007/BF03246504

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