Abstract
The integrated toxicities of 4-tert-octylphenol (t-OP) on Siganus oramin were investigated by dietary administration at doses of 5, 25 and 125 mg/kg body weight over 28 days. Significant increase was observed in the activity of hepatic glutathione S-transferase at 125 mg/kg on both day 14 and 28 in males, and at all doses on day 28 in females, and in hepatosomatic index at 25 mg/kg on day 14 in both sexes. Plasma levels of testosterone and cortisol decreased significantly at all doses on day 28. Histopathologic changes in liver, spleen, intestine and testis deteriorated with increasing doses and duration. The results suggest that S. oramin is sensitive to t-OP, and the above endpoints may be potential biomarkers for evaluating toxicities of environmental pollutants such as t-OP.
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References
Bendsen E, Laursen S, Olesen C (2001) Effect of 4-octylphenol on germ cell number in cultured human fetal gonads. Hum Reprod 16:236–243
Ferrara F, Fabietti F, Delise M, Funari E (2005) Alkylphenols and alkylphenol ethoxylates contamination of crustaceans and fishes from the Adriatic Sea (Italy). Chemosphere 59:1145–1150
Figueiredo-Fernandes A, Fontaínhas-Fernandes A, Peixoto F, Rocha E, Reis-Henriques MA (2006) Effects of gender and temperature on oxidative stress enzymes in Nile tilapia Oreochromis niloticus exposed to paraquat. Pest Biochem Physiol 85:97–103
Hanioka N, Jinno H, Chung YS, Nishimura T, Tanaka-Kagawa T, Ando M (2000) Effect of 4-tert-octylphenol on cytochrome P450 enzymes in rat liver. Arch Toxicol 73:625–631
Isidori M, Lavorgna M, Nardelli A, Parrella A (2006) Toxicity on crustaceans and endocrine disrupting activity on Saccharomyces cerevisiae of eight alkylphenols. Chemosphere 64:135–143
Jokanovic M (2001) Biotransformation of organophosphorus compounds. Toxicology 166:139–160
Kinnberg K, Korsgaard B, Bjerregaard P (2003) Effects of octylphenol and 17β-estradiol on the gonads of guppies (Poecilia reticulata) exposed as adults via the water or as embryos via the mother. Comp Biochem Physiol 134C:45–55
Kretschmer XC, Baldwin WS (2005) CAR and PXR: xenosensors of endocrine disrupters? Chem Biol Interact 155:111–128
Lai MS, Cheung YH, Chan KM (1999) Metal concentrations in tissues of rabbitfish (Siganus oramin) collected from Tolo Harbour and Victoria Harbour in Hong Kong. Mar Poll Bull 39:234–238
Madsen LL, Korsgaard B, Bjerregaard P (2006) Oral single pulse exposure of flounder Platichthys flesus to 4-tert-octylphenol: relations between tissue levels and estrogenic effects. Mar Environ Res 61:352–362
Monteiro DA, De Almeida JA, Rantin FT, Kalinin AL (2006) Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus, exposed to organophosphorus insecticide Folisuper 600 (methyl parathion). Comp Biochem Physiol 143C:141–149
Pacheco M, Santos MA (2002) Biotransformation, genotoxic, and histopathological effects of environmental contaminants in European eel (Anguilla anguilla L.). Ecotoxicol Environ Saf 53:331–347
Ronisz D, Larsson DGJ, Förlin L (1999) Seasonal variations in the activities of selected hepatic biotransformation and antioxidant enzymes in eelpout (Zoarces viviparus). Comp Biochem Physiol 124C:271–279
Thophon S, Kruatrachue M, Upatham ES, Pokethitiyook P, Sahaphong S, Jaritkhuan S (2003) Histopathological alterations of white seabass, Lates calcarifer, in acute and subchronic cadmium exposure. Environ Pollut 121:307–320
Acknowledgements
We thank Dr Margaret B. Murphy of City University of Hong Kong for earnestly revising this manuscript. This work was supported by grants from the National Natural Science Foundation of China (No. 30570325, 30671629), the NSF of Guangdong Province (No. 32046) and the Science and Technology Project of Guangdong Province (2005B20301013, 2006A36502004) to Y-Y L.
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Du, Y.B., Li, Y.Y., Zhen, Y.J. et al. Toxic Effects in Siganus oramin by Dietary Exposure to 4-tert-Octylphenol. Bull Environ Contam Toxicol 80, 534–538 (2008). https://doi.org/10.1007/s00128-008-9388-7
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DOI: https://doi.org/10.1007/s00128-008-9388-7