Abstract
The occurrence of 15 pharmaceuticals and personal care products in the influent and effluent from the wastewater treatment plant (WWTP) and its receiving water in Beijing, China were determined. Results from the present study confirmed that caffeine, N,N-diethyl-m-toluamide and chloramphenicol were removed at a high rate (>70 % efficiency). In contrast, removal efficiency of the other 12 compounds was quite poor (ranged from −40 % to 58 %). Some compounds in the receiving river were present at higher concentrations compared to those in the WWTP effluent, indicating that sources other than treated effluents are present. The risk to the aquatic environment was estimated by a ratio of measured environmental concentration and predicted no-effect concentration. For those compounds found in the effluent and surface water, mefenamic acid, trimethoprim and gemfibrozil may pose a medium risk to aquatic environment.
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References
Bendz D, Paxeus NA, Ginn TR, Logec FJ (2005) Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Hoje River in Sweden. J Hazard Mater 122:195–204
Chang H, Wan Y, Hu JY (2009) Determination and source apportion of five classes of steroid hormones in urban rivers. Environ Sci Technol 43:7691–7698
Costanz SD, Watkinson AJ, Murby EJ, Kolpin DW, Sandstrom MW (2007) Is there a risk associated with the insect repellent DEET (N, N-Diethyl-M-Toluamide) commonly found in aquatic environments? Sci Total Environ 384(1–3):214–220
Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107:907–938
EMEA (European Agency for the Evaluation of Medicinal Products) (2006) Guideline on the environmental risk assessment of medicinal products for human use CPMP/S WP/4447/00. http://www.ema.europa.eu/ema/. Accessed 13 May 3 2013
Heberer T (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 131:5–17
Heeb F, Singer H, Pernet-Coudrier B, Qi WX, Liu HJ, Longrée P, Müller B, Berg M (2012) Organic micropollutants in rivers downstream of the megacity beijing: sources and mass fluxes in a large-scale wastewater irrigation system. Environ Sci Technol 46:8680–8688
Hernando MD, Mezcua M, Fernandez-Alba AR, Barcelo D (2006) Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 69(2):334–342
Jelić A, Gros M, Petrović M, Ginebreda A, Barceló D (2012) Occurrence and elimination of pharmaceuticals during conventional wastewater treatment. In: Barceló D, Kostianoy AG (eds) Handbook of environmental chemistry, vol 19. Springer Berlin, Heidelberg, pp 1–24
Jia A, Wan Y, Xiao Y, Hu JY (2012) Occurrence and fate of quinolone and fluoroquinolone antibiotics in a municipal sewage treatment plant. Water Res 46:387–394
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2009) The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Res 43:363–380
Lishman L, Smyth SA, Sarafin K, Kleywegt S, Toito J, Peart T et al (2006) Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada. Sci Total Environ 367:544–558
Peng X, Wang Z, Kuang W, Tan J, Li K (2006) A preliminary study on the occurrence and behavior of sulfonamides, ofloxacin and chloramphenicol antimicrobials in wastewater of two sewage treatment plants in Guangzhou, China. Sci Total Environ 371:314–322
Rosal R, Rodrìguez A, Perdigòn-Melòn JA, Petre A, Garcìa-Calvo E, Gòmez MJ et al (2010) Occurrence of emerging pollutants in urban wastewater and their removal through biological treatment followed by ozonation. Water Res 44:578–588
Schwab BW, Hayes EP, Fiori JM, Mastrocco FJ et al (2005) Human pharmaceuticals in us surface waters: a human health risk assessment. Regul Toxicol Pharmacol 42(3):296–312
Spongberg AL, Witter JD (2008) Pharmaceutical compounds in the wastewater process stream in Northwest Ohio. Sci Total Environ 397:148–157
Sui Q, Huang J, Deng SB, Chen WW, Yu G (2011) Seasonal variation in the occurrence and removal of pharmaceuticals and personal care products in different biological wastewater treatment. Environ Sci Technol 45:3341–3348
Tewari S, Jindal R, Kho YL, Eo S, Choi K (2013) Major pharmaceutical residues in wastewater treatment plants and receiving waters in Bangkok, Thailand, and associated ecological risks. Chemosphere 91:697–704
Verlicchi P, Al Aukidy M, Zambello E (2012) Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment: a review. Sci Total Environ 429:123–155
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This research was supported by the Chinese National Environmental Protection Public Welfare Industry Targeted Research Fund (No. 201309001) and the China Postdoctoral Science Foundation (2013M530640).
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Dai, G., Huang, J., Chen, W. et al. Major Pharmaceuticals and Personal Care Products (PPCPs) in Wastewater Treatment Plant and Receiving Water in Beijing, China, and Associated Ecological Risks. Bull Environ Contam Toxicol 92, 655–661 (2014). https://doi.org/10.1007/s00128-014-1247-0
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DOI: https://doi.org/10.1007/s00128-014-1247-0