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Gentherapie in der Orthopädie

Gene therapy in orthopaedic surgery

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Zusammenfassung

Gentherapie in der Orthopädie wird intensiv im Rahmen verschiedener vererbbarer und nichtvererbbarer orthopädischer Krankheiten untersucht. Der experimentelle Fortschritt auf diesem Gebiet ist durch die Komplexität von Vektorauswahl und -herstellung, Gentransfertechnik, Applikationsweg in geeigneten Tier-Modellen sowie dem Nachweis auf struktureller und funktioneller Ebene gekennzeichnet. Die ersten klinischen Studien zur Gentherapie der chronischen Polyarthritis haben bereits ihre praktische Durchführbarkeit demonstriert. Es ist wahrscheinlich, dass genbasierte Verfahren zur Erweiterung und Verbesserung bestehender orthopädisch-chirurgischer Therapien führen werden.

Abstract

Gene therapy in orthopaedic surgery is being intensively studied in the context of different genetic and nonmendelian diseases. Experimental progress in this area is characterized by the complexity of gene vector selection and production, gene transfer technology, application routes, choice of animal models, and evaluation of its efficacy using structural and functional parameters. The first clinical studies for gene therapy of rheumatoid arthritis already demonstrated their practical feasibility. Current data indicate that gene-based therapies are effective in promoting the repair of articular cartilage, and bone defects. Such strategies may lead to the development of novel molecular therapies treatments in orthopaedic surgery.

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Danksagung

Unterstützt durch die Deutsche Forschungsgemeinschaft (DFG MA 2363/1–1, /1–2, /1–3 und CU 55/1–1, /1–2, /1–3) und die Deutsche Arthrose-Hilfe. Wir danken Frau Anja Weimer für redaktionelle Arbeit am Manuskript.

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Authors and Affiliations

  1. Labor für Experimentelle Orthopädie Klinik für Orthopädie und Orthopädische Chirurgie, Universitätsklinikum des Saarlandes, 66421 , Homburg

    H. Madry, D. Kohn & M. Cucchiarini

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  1. H. Madry
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  2. D. Kohn
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  3. M. Cucchiarini
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Correspondence to H. Madry.

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Madry, H., Kohn, D. & Cucchiarini, M. Gentherapie in der Orthopädie. Orthopäde 35, 1193–1204 (2006). https://doi.org/10.1007/s00132-006-1016-9

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  • DOI: https://doi.org/10.1007/s00132-006-1016-9

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