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Molecularly imprinted polymers: towards highly selective stationary phases in liquid chromatography and capillary electrophoresis

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Abstract

Molecularly imprinted polymers (MIPs) are synthetic polymers with a predetermined selectivity for a given analyte, or group of structurally related compounds, that make them ideal materials to be used in separation processes. In this sense, it is not surprising that the first applications of MIPs were as tailor-made chiral stationary phases in liquid chromatography. However, peak broadening and tailing, especially of the more retained enantiomers, were observed. Accordingly, this paper gives an overview of the attempts carried out during the recent years to improve the chromatographic performance of MIPs in liquid chromatography and capillary electrophoresis as well as the more recent applications. We conclude that MIPs are very promising materials to be used as selective stationary phases in chromatography although further developments are necessary in order to fully exploit their potential.

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Acknowledgements

The authors wish to thank Dr Josephine McCourt for linguistic advice. A. Martin-Esteban acknowledges Spanish Ministry of Science and Technology for a Ramón y Cajal Contract.

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  1. E. Turiel

    Present address: Departamento de Quimica y Materiales, Facultad de Ciencias, Universidad Europea CEES, Villaviciosa de Odón, 28670, Madrid, Spain

Authors and Affiliations

  1. Institute for Reference Materials and Measurements, Joint Research Centre, European Commission, 2440, Geel, Belgium

    E. Turiel & A. Martin-Esteban

  2. Departemento de Medio Ambiente, INIA, Carretera de A Coruña km 7,5, 28040, Madrid, Spain

    A. Martin-Esteban

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  1. E. Turiel
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  2. A. Martin-Esteban
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Correspondence to A. Martin-Esteban.

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Turiel, E., Martin-Esteban, A. Molecularly imprinted polymers: towards highly selective stationary phases in liquid chromatography and capillary electrophoresis. Anal Bioanal Chem 378, 1876–1886 (2004). https://doi.org/10.1007/s00216-003-2331-1

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  • DOI: https://doi.org/10.1007/s00216-003-2331-1

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