Abstract
This article provides an overview of the applications of biosensors in analysis and monitoring of endocrine-disrupting compounds (EDCs) in the environment. Special attention is devoted to the various types of physical-chemical signal transduction elements, biological mechanisms employed as sensing elements and techniques used for immobilisation of the bioreceptor molecules on the transducer surface. Two different classes of biosensors for EDCs are considered: biosensors that measure endocrine-disrupting effects, and biosensors that respond to the presence of a specific substance (or group of substances) based on the specific recognition of a biomolecule. Several examples of them are presented to illustrate the power of the biosensor technology for environmental applications. Future trends in the development of new, more advanced devices are also outlined.
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Acknowledgements
This work has been supported by AWACSS (EVK1-CT-2000-00045) and by RADAR (QLRT-2000-01670). Sara Rodriguez acknowledges Ministerio de Ciencia y Tecnología (Project PPQ 2000-3006-CE) and the I3P Program (Itinerario integrado de inserción professional; co-financed by CSIC and European Social Funds). María J. López de Alda acknowledges her Ramon y Cajal contract from the Spanish Ministry of Science and Technology.
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Rodriguez-Mozaz, S., Marco, MP., Lopez de Alda, M. et al. Biosensors for environmental monitoring of endocrine disruptors: a review article. Anal Bioanal Chem 378, 588–598 (2004). https://doi.org/10.1007/s00216-003-2385-0
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DOI: https://doi.org/10.1007/s00216-003-2385-0