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Synthesis of magnetic nanoparticles and their application to bioassays

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Abstract

Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.

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Acknowledgements

The authors acknowledge the financial support provided by Grants-in-Aid from COE Research (Molecular Nano-Engineering), Encouraging Development Strategic Research Centers Program, Special Coordination Funds for Promoting Science and Technology (Establishment of Consolidated Research Institute for Advanced Science and Medical Care), and the 21st Century COE Program (Center for Practical Nano-Chemistry) of the Ministry of Education, Culture, Sports, Science and Technology, Japan. The authors would like to acknowledge Dr. Y. Okinaka for valuable discussions.

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Authors and Affiliations

  1. Department of Applied Chemistry, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan

    Tetsuya Osaka & Hironori Iida

  2. Institute for Biomedical Engineering, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku, Tokyo, 162-0041, Japan

    Tetsuya Osaka, Tadashi Matsunaga, Takuya Nakanishi, Atsushi Arakaki & Daisuke Niwa

  3. Department of Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan

    Tadashi Matsunaga & Atsushi Arakaki

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  1. Tetsuya Osaka
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  2. Tadashi Matsunaga
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  3. Takuya Nakanishi
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  4. Atsushi Arakaki
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  5. Daisuke Niwa
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  6. Hironori Iida
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Correspondence to Tetsuya Osaka.

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Osaka, T., Matsunaga, T., Nakanishi, T. et al. Synthesis of magnetic nanoparticles and their application to bioassays. Anal Bioanal Chem 384, 593–600 (2006). https://doi.org/10.1007/s00216-005-0255-7

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  • DOI: https://doi.org/10.1007/s00216-005-0255-7

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