Skip to main content
SpringerLink
Log in

Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA

  • Review
  • Published:
Analytical and Bioanalytical Chemistry Aims and scope Submit manuscript

Abstract

Many of the current investigations on the environmental and human health risks of engineered nanomaterials focus on their short-term acute toxicity. However, the long-term chronic effects of nanomaterials on living systems, and in particular, on the genetic components of living systems, also warrant attention. An increasing number of nanomaterial safety studies include an assessment of genotoxicity as part of the overall risk evaluation. The potential of nanomaterials to directly or indirectly promote the formation of reactive oxygen species is one of the primary steps in their genotoxic repertoire. The subsequent modification of genomic DNA by reactive oxygen species could lead to the development of mutagenesis, carcinogenesis, or other age-related diseases if the DNA damage is not repaired. This review focuses on the interactions of nanomaterials with DNA and specifically on the capacity of some nanomaterials to induce oxidative damage to DNA. A critical assessment of the analytical methodology and the potential biochemical mechanisms involved in nanomaterial induction of oxidative damage to DNA is presented, results obtained for the various studies with each nanomaterial are compared, and recommendations for future research are discussed. Researchers should consider, among other experimental recommendations, (1) the application of more chromatography-based and mass-spectrometry-based analytical techniques to the assessment of oxidative damage to DNA to facilitate an enhanced understanding of DNA damage mechanisms and (2) the verification of cellular viability before conducting genotoxicity assays to reduce the impact of fragmented DNA, formed as a consequence of cell death, on DNA damage measurements.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Nel A, Xia T, Madler L, Li N (2006) Science 311:622–627

    Article  CAS  Google Scholar 

  2. Li N, Xia T, Nel AE (2008) Free Radic Biol Med 44:1689–1699

    Article  CAS  Google Scholar 

  3. Warheit DB (2008) Toxicol Sci 101:183–185

    Article  CAS  Google Scholar 

  4. Gonzalez L, Lison D, Kirsch-Volders M (2009) Nanotoxicology 2:252–273

    Article  Google Scholar 

  5. Schins RPF, van Berlo D, Wessels A, Gerloff K, Boots A, Scherbart A, Cassee FR, Gerlofs-Nijland M, Fokkens P, Schooten FJ, Albrecht C (2009) Mutagenesis 24:24

    Google Scholar 

  6. Singh N, Manshian B, Jenkins GJS, Griffiths SM, Williams PM, Maffeis TGG, Wright CJ, Doak SH (2009) Biomaterials 30:3891–3914

    Article  CAS  Google Scholar 

  7. Halliwell B, Gutteridge JMC (2007) Free radicals in biology and medicine. Oxford University Press, New York

    Google Scholar 

  8. Knaapen AM, Seiler F, Schilderman PAEL, Nehls P, Bruch J, Schins RPF, Borm PJA (1999) Free Radic Biol Med 27:234–240

    Article  CAS  Google Scholar 

  9. Evans DE, Dizdaroglu M, Cooke MS (2004) Mutat Res 567:1–61

    Article  CAS  Google Scholar 

  10. Khanna KK, Jackson SP (2001) Nat Genet 27:247–254

    Article  CAS  Google Scholar 

  11. Lan L, Nakajima S, Oohata Y, Takao M, Okano S, Masutani M, Wilson SH, Yasui A (2004) Proc Natl Acad Sci USA 101:13738–13743

    Article  Google Scholar 

  12. Olive PL, Banath JP (2006) Nat Protoc 1:23–29

    Article  CAS  Google Scholar 

  13. Collins AR (2004) Mol Biotechnol 26:249–261

    Article  CAS  Google Scholar 

  14. Kumaravel TS, Vilhar B, Faux SP, Jha AN (2009) Cell Biol Toxicol 25:53–64

    Article  CAS  Google Scholar 

  15. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF (2000) Environ Mol Mutagen 35:206–221

    Article  CAS  Google Scholar 

  16. Johansson C, Moller P, Forchhammer L, Loft S, Godschalk RWL, Langie SAS, Lumeij S, Jones GDD, Kwok RWL, Azqueta A, Phillips DH, Sozeri O, Routledge MN, Charlton AJ, Riso P, Porrini M, Allione A, Matullo G, Palus J, Stepnik M, Collins AR, Moller L (2009) Mutagenesis 25:125–132

    Article  CAS  Google Scholar 

  17. Forchhammer L, Brauner EV, Folkmann JK, Danielsen PH, Nielsen C, Jensen AW, Loft S, Friis G, Moller P (2008) Mutagenesis 23:223–231

    Article  CAS  Google Scholar 

  18. Mroz RM, Schins RPF, Li H, Jimenez LA, Drost EM, Holownia A, MacNee W, Donaldson K (2008) Eur Respir J 31:241–251

    Article  CAS  Google Scholar 

  19. Gurr JR, Wang ASS, Chen CH, Jan KY (2005) Toxicology 213:66–73

    Article  CAS  Google Scholar 

  20. Jacobsen NR, Pojana G, White P, Moller P, Cohn CA, Korsholm KS, Vogel U, Marcomini A, Loft S, Wallin H (2008) Environ Mol Mutagen 49:476–487

    Article  CAS  Google Scholar 

  21. Jacobsen NR, Saber AT, White P, Moller P, Pojana G, Vogel U, Loft S, Gingerich J, Soper L, Douglas GR, Wallin H (2007) Environ Mol Mutagen 48:451–461

    Article  CAS  Google Scholar 

  22. Karlsson HL, Cronholm P, Gustafsson J, Moller L (2008) Chem Res Toxicol 21:1726–1732

    Article  CAS  Google Scholar 

  23. Karlsson HL, Gustafsson J, Cronholm P, Moller L (2009) Toxicol Lett 188:112–118

    Article  CAS  Google Scholar 

  24. Muslimovic A, Ismail IH, Gao Y, Hammarsten O (2008) Nat Protoc 3:1187–1193

    Article  CAS  Google Scholar 

  25. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM (1998) J Biol Chem 273:5858–5868

    Article  CAS  Google Scholar 

  26. Shafirovich V, Singh C, Geacintov NE (2003) J Chem Educ 80:1297–1299

    Article  CAS  Google Scholar 

  27. Olive PL (2006) Environ Mol Mutagen 11:487–495

    Article  Google Scholar 

  28. Olive PL, Chan APS, Cu CS (1988) Cancer Res 48:6444–6449

    CAS  Google Scholar 

  29. Dizdaroglu M, Jaruga P, Birincioglu M, Rodriguez H (2002) Free Radic Biol Med 32:1102–1115

    Article  CAS  Google Scholar 

  30. Voller A, Bartlett A, Bidwell DE (1978) J Clin Pathol 31:507–520

    Article  CAS  Google Scholar 

  31. Burnett R, Guichard Y, Barale E (1997) Toxicology 119:83–93

    Article  CAS  Google Scholar 

  32. Dorsey JG, Cooper WT (1994) Anal Chem 66:857A–867A

    Article  CAS  Google Scholar 

  33. Greenberg MM, Hantosi Z, Wiederholt CJ, Rithner CD (2001) Biochemistry 40:15856–15861

    Article  CAS  Google Scholar 

  34. Feig DI, Sowers L, Loeb LA (1994) Proc Natl Acad Sci USA 91:6609–6613

    Article  CAS  Google Scholar 

  35. Kreutzer DA, Essigmann JM (1998) Proc Natl Acad Sci USA 95:3578–3582

    Article  CAS  Google Scholar 

  36. Purmal AA, Kow TW, Wallace SS (1994) Nucleic Acids Res 22:3930–3935

    Article  CAS  Google Scholar 

  37. Wallace SS (2002) Free Radic Biol Med 33:1–14

    Article  CAS  Google Scholar 

  38. Delaney MO, Wiederholt CJ, Greenberg MM (2002) Angew Chem Int Ed 41:771–773

    Article  CAS  Google Scholar 

  39. Wiederholt CJ, Greenberg MM (2002) J Am Chem Soc 124:7278–7279

    Article  CAS  Google Scholar 

  40. Dizdaroglu M, Kirkali G, Jaruga P (2008) Free Radic Biol Med 45:1610–1621

    Article  CAS  Google Scholar 

  41. Kalam MA, Haraguchi K, Chandani S, Loechler EL, Moriya M, Greenberg MM, Basu AK (2006) Nucleic Acids Res 34:2305–2315

    Article  CAS  Google Scholar 

  42. Hurt RH, Monthioux M, Kane A (2006) Carbon 44:1028–1033

    Article  CAS  Google Scholar 

  43. Landsiedel R, Kapp MD, Schulz M, Wiench K, Oesch F (2009) Mutat Res Rev Mutat Res 681:241–258

    CAS  Google Scholar 

  44. Gerloff K, Albrecht C, Boots AW, Forster I, Schins RPF (2009) Nanotoxicology 3:355–364

    Article  CAS  Google Scholar 

  45. Mroz RM, Schins RPF, Li H, Drost EM, Macnee W, Donaldson K (2007) J Physiol Pharmacol 58:461–470

    Google Scholar 

  46. Yang H, Liu C, Yang DF, Zhang HS, Xi ZG (2009) J Appl Toxicol 29:69–78

    Article  CAS  Google Scholar 

  47. Zhong BZ, Whong WZ, Ong TM (1997) Mutat Res Genet Toxicol Environ Mutagen 393:181–187

    Article  CAS  Google Scholar 

  48. Jacobsen NR, Moller P, Jensen KA, Vogel U, Ladefoged O, Loft S, Wallin H (2009) Part Fibre Toxicol 6:2

    Article  CAS  Google Scholar 

  49. Totsuka Y, Higuchi T, Imai T, Nishikawa A, Nohmi T, Kato T, Masuda S, Kinae N, Hiyoshi K, Ogo S, Kawanishi M, Yagi T, Ichinose T, Fukumori N, Watanabe M, Sugimura T, Wakabayashi K (2009) Part Fibre Toxicol 6:23

    Article  CAS  Google Scholar 

  50. Gallagher J, Sams R, Inmon J, Gelein R, Elder A, Oberdorster G, Prahalad AK (2003) Toxicol Appl Pharmacol 190:224–231

    Article  CAS  Google Scholar 

  51. Kisin ER, Murray AR, Keane MJ, Shi XC, Schwegler-Berry D, Gorelik O, Arepalli S, Castranova V, Wallace WE, Kagan VE, Shvedova AA (2007) J Toxicol Environ Health Part A 70:2071–2079

    Article  CAS  Google Scholar 

  52. Lindberg HK, Falck GCM, Suhonen S, Vippola M, Vanhala E, Catalan J, Savolainen K, Norppa H (2009) Toxicol Lett 186:166–173

    Article  CAS  Google Scholar 

  53. Pacurari M, Yin XJ, Ding M, Leonard SS, Schwegler-Berry D, Ducatman BS, Chirila M, Endo M, Castranova V, Vallyathan V (2008) Nanotoxicology 2:155–170

    Article  CAS  Google Scholar 

  54. Pacurari M, Yin XJ, Zhao JS, Ding M, Leonard SS, Schwegier-Berry D, Ducatman BS, Sbarra D, Hoover MD, Castranova V, Vallyathan V (2008) Environ Health Perspect 116:1211–1217

    Article  CAS  Google Scholar 

  55. Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR (2008) Sensors 8:488–499

    Article  CAS  Google Scholar 

  56. Zhu L, Chang DW, Dai LM, Hong YL (2007) Nano Lett 7:3592–3597

    Article  CAS  Google Scholar 

  57. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WAH, Seaton A, Stone V, Brown S, MacNee W, Donaldson K (2008) Nat Nanotechnol 3:423–428

    Article  CAS  Google Scholar 

  58. Shvedova AA, Kisin ER, Porter D, Schulte P, Kagan VE, Fadeel B, Castranova V (2009) Pharmacol Ther 121:192–204

    Article  CAS  Google Scholar 

  59. Jakubek LM, Marangoudakis S, Raingo J, Liu XY, Lipscombe D, Hurt RH (2009) Biomaterials 30:6351–6357

    Article  CAS  Google Scholar 

  60. Liu XY, Gurel V, Morris D, Murray DW, Zhitkovich A, Kane AB, Hurt RH (2007) Adv Mater 19:2790

    Article  CAS  Google Scholar 

  61. Folkmann JK, Risom L, Jacobsen NR, Wallin H, Loft S, Moller P (2009) Environ Health Perspect 117:703–708

    CAS  Google Scholar 

  62. Cherukuri P, Gannon CJ, Leeuw TK, Schmidt HK, Smalley RE, Curley SA, Weisman B (2006) Proc Natl Acad Sci USA 103:18882–18886

    Article  CAS  Google Scholar 

  63. Liu Z, Davis C, Cai WB, He L, Chen XY, Dai HJ (2008) Proc Natl Acad Sci USA 105:1410–1415

    Article  CAS  Google Scholar 

  64. Singh R, Pantarotto D, Lacerda L, Pastorin G, Klumpp C, Prato M, Bianco A, Kostarelos K (2006) Proc Natl Acad Sci USA 103:3357–3362

    Article  CAS  Google Scholar 

  65. Yang ST, Guo W, Lin Y, Deng XY, Wang HF, Sun HF, Liu YF, Wang X, Wang W, Chen M, Huang YP, Sun YP (2007) J Phys Chem C 111:17761–17764

    Article  CAS  Google Scholar 

  66. Ferguson PL, Chandler GT, Templeton RC, Demarco A, Scrivens WA, Englehart BA (2008) Environ Sci Technol 42:3879–3885

    Article  CAS  Google Scholar 

  67. Leeuw TK, Reith RM, Simonette RA, Harden ME, Cherukuri P, Tsyboulski DA, Beckingham KM, Weisman RB (2007) Nano Lett 7:2650–2654

    Article  CAS  Google Scholar 

  68. Petersen EJ, Akkanen J, Kukkonen JVK, Weber WJ Jr (2009) Environ Sci Technol 43:2969–2975

    Article  CAS  Google Scholar 

  69. Petersen EJ, Huang QG, Weber WJ Jr (2010) Environ Toxicol Chem 29:1106–1112

    CAS  Google Scholar 

  70. Petersen EJ, Huang QG, Weber WJ Jr (2008) Environ Sci Technol 42:3090–3095

    Article  CAS  Google Scholar 

  71. Petersen EJ, Huang QG, Weber WJ Jr (2008) Environ Health Perspect 116:496–500

    CAS  Google Scholar 

  72. Worle-Knirsch JM, Pulskamp K, Krug HF (2006) Nano Lett 6:1261–1268

    Article  CAS  Google Scholar 

  73. Lin MH, Hsu TS, Yang PM, Tsai MY, Perng TP, Lin LY (2009) Int J Radiat Biol 85:214–226

    Article  CAS  Google Scholar 

  74. Brown DM, Kinloch IA, Bangert U, Windle AH, Walter DM, Walker GS, Scotchford CA, Donaldson K, Stone V (2007) Carbon 45:1743–1756

    Article  CAS  Google Scholar 

  75. Dhawan A, Taurozzi JS, Pandey AK, Shan WQ, Miller SM, Hashsham SA, Tarabara VV (2006) Environ Sci Technol 40:7394–7401

    Article  CAS  Google Scholar 

  76. Jafvert CT, Kulkarni PP (2008) Environ Sci Technol 42:5945–5950

    Article  CAS  Google Scholar 

  77. Henry TB, Menn FM, Fleming JT, Wilgus J, Compton RN, Sayler GS (2007) Environ Health Perspect 115:1059–1065

    Article  CAS  Google Scholar 

  78. Kovochich M, Espinasse B, Auffan M, Hotze EM, Wessel L, Xia T, Nel AE, Wiesner MR (2009) Environ Sci Technol 43:6378–6384

    Article  CAS  Google Scholar 

  79. Spohn P, Hirsch C, Hasler F, Bruinink A, Krug HF, Wick P (2009) Environ Pollut 157:1134–1139

    Article  CAS  Google Scholar 

  80. Bernstein R, Prat F, Foote CS (1999) J Am Chem Soc 121:464–465

    Article  CAS  Google Scholar 

  81. Isakovic A, Markovic Z, Todorovic-Markovic B, Nikolic N, Vranjes-Djuric S, Mirkovic M, Dramicanin M, Harhaji L, Raicevic N, Nikolic Z, Trajkovic V (2006) Toxicol Sci 91:173–183

    Article  CAS  Google Scholar 

  82. Sera N, Tokiwa H, Miyata N (1996) Carcinogenesis 17:2163–2169

    Article  CAS  Google Scholar 

  83. Tokuyama H, Yamago S, Nakamura E (1993) J Am Chem Soc 115:7918–919

    Article  CAS  Google Scholar 

  84. Nielsen GD, Roursgaard M, Jensen KA, Poulsen SS, Larsen ST (2008) Basic Clin Pharmacol Toxicol 103:197–208

    Article  CAS  Google Scholar 

  85. Moreira S, Silva NB, Almeida-Lima J, Rocha HAO, Medeiros SRB, Alves C, Gama FM (2009) Toxicol Lett 189:235–241

    Article  CAS  Google Scholar 

  86. Colognato R, Bonelli A, Ponti J, Farina M, Bergamaschi E, Sabbioni E, Migliore L (2008) Mutagenesis 23:377–382

    Article  CAS  Google Scholar 

  87. Ponti J, Sabbioni E, Munaro B, Broggi F, Marmorato P, Franchini F, Colognato R, Rossi F (2009) Mutagenesis 24:439–445

    Article  CAS  Google Scholar 

  88. Colvin VL (2003) Nat Biotechnol 21:1166–1170

    Article  CAS  Google Scholar 

  89. Oberdorster G, Oberdorster E, Oberdorster J (2005) Environ Health Perspect 113:823–839

    Article  CAS  Google Scholar 

  90. Papageorgiou I, Brown C, Schins R, Singh S, Newson R, Davis S, Fisher J, Ingham E, Case CP (2007) Biomaterials 28:2946–2958

    Article  CAS  Google Scholar 

  91. Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP (2009) Nat Nanotechnol 4:876–883, http://www.nature.com/nnano/journal/v4/n12/pdf/nnano.2009.313.pdf

    Article  CAS  Google Scholar 

  92. Baldwin EL, Byl JA, Osheroff N (2004) Biochemistry 43:728–735

    Article  CAS  Google Scholar 

  93. Kopera E, Schwerdtle T, Hartwig A, Bal W (2004) Chem Res Toxicol 17:1452–1458

    Article  CAS  Google Scholar 

  94. Midander M, Cronholm P, Karlsson HL, Elihn K, Moller L, Leygraf C, Wallinder IO (2009) Small 5:389–399

    Article  CAS  Google Scholar 

  95. Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD (2005) Small 1:325–327

    Article  CAS  Google Scholar 

  96. Ponti J, Colognato R, Franchini F, Gioria S, Simonelli F, Abbas K, Uboldi C, Kirkpatrick CJ, Holzwarth U, Rossi F (2009) Nanotoxicology 3:296–306

    Article  CAS  Google Scholar 

  97. Rosi NL, Giljohann DA, Thaxton CS, Lytton-Jean AKR, Han MS, Mirkin CA (2006) Science 312:1027–1030

    Article  CAS  Google Scholar 

  98. Shenoy D, Fu W, Li JB, Crasto C, Jones G, DimMarzio C, Sridhar S, Amiji M (2006) J Nanomed 1:51–57

    Article  CAS  Google Scholar 

  99. Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M (2005) Langmuir 21:10644–10654

    Article  CAS  Google Scholar 

  100. Tkachenko AG, Xie H, Liu T, Coleman D, Ryan J, Glomm W, Shipton MK, Franzen S, Feldheim DL (2004) Bioconjug Chem 14:482–490

    Article  CAS  Google Scholar 

  101. Tsoli M, Kuhn H, Brandau W, Esche H, Schmid G (2005) Small 1:841–844

    Article  CAS  Google Scholar 

  102. Kang B, Mackey MA, El-Sayed MA (2010) J Am Chem Soc 132:1517–1519

    Article  CAS  Google Scholar 

  103. Grigg J, Tellabati A, Rhead S, Almeida GM, Higgins JA, Bowman KJ, Jones GD, Howes PB (2009) Nanotoxicology 3:348–345

    Article  CAS  Google Scholar 

  104. Kang JS, Yum YN, Kim JH, Song H, Jeong J, Lim YT, Chung BH, Park SN (2009) Biomol Ther 17:92–97

    Article  CAS  Google Scholar 

  105. Li JJ, Zou L, Hartono D, Ong CN, Bay BH, Yung LYL (2008) Adv Mater 20:138–142

    Article  CAS  Google Scholar 

  106. Chithrani BD, Ghazani AA, Chan WCW (2006) Nano Lett 6:662–668

    Article  CAS  Google Scholar 

  107. Chithrani BD, Chan WCW (2007) Nano Lett 7:1542–1550

    Article  CAS  Google Scholar 

  108. Zhang Q, Kusaka Y, Sato K (1998) J Toxicol Environ Health Part A 53:423–438

    Article  CAS  Google Scholar 

  109. Pelka J, Gehrke H, Esselen M, Turk M, Crone M, Brase S, Muller T, Blank H, Send W, Zibat V, Brenner P, Schneider R, Gerthsen D, Marko D (2009) Chem Res Toxicol 22:649–659

    Article  CAS  Google Scholar 

  110. Coste F, Ober M, Carell T, Boiteux S, Zelwer C, Castaing B (2004) J Biol Chem 279:44074–44083

    Article  CAS  Google Scholar 

  111. Navarro E, Piccapietra F, Wagner B, Marconi F, Kaegi R, Odzak N, Sigg L, Behra R (2008) Environ Sci Technol 42:8959–8964

    Article  CAS  Google Scholar 

  112. Arakawa H, Neault JF, Tajmir-Riahi HA (2001) Biophys J 81:1580–1587

    Article  CAS  Google Scholar 

  113. Ahamed M, Karns M, Goodson M, Rowe J, Hussain SM, Schlager JJ, Hong YL (2008) Toxicol Appl Pharmacol 233:404–410

    Article  CAS  Google Scholar 

  114. AshaRani PV, Mun GLK, Hande MP, Valiyaveettil S (2009) ACS Nano 3:279–290

    Article  CAS  Google Scholar 

  115. Kim S, Choi JE, Choi J, Chung KH, Park K, Yi J, Ryu DY (2009) Toxicol In Vitro 23:1076–1084

    Article  CAS  Google Scholar 

  116. Sawosz E, Grodzik M, Zielinska M, Niemiec T, Olszanka B, Chwalibog A (2009) Arch Geflugelk 73:208–213

    CAS  Google Scholar 

  117. Aruoma OI, Halliwell B, Gajewski E, Dizdaroglu M (1989) J Biol Chem 264:20509–20512

    CAS  Google Scholar 

  118. Aruoma OI, Halliwell B, Gajewski E, Dizdaroglu M (1991) Biochem J 273:601–604

    CAS  Google Scholar 

  119. Gwinn MR, Leonard SS, Sargent LM, Lowry DT, McKinstry KT, Meighan T, Reynolds SH, Kashon M, Castranova V, Vallyathan V (2009) J Toxicol Environ Health Part A 72:1509–1519

    Article  CAS  Google Scholar 

  120. Chen M, von Mikecz A (2005) Exp Cell Res 305:51–62

    Article  CAS  Google Scholar 

  121. Limbach LK, Wick P, Manser P, Grass RN, Bruinink A, Start WJ (2007) Environ Sci Technol 41:4158–4163

    Article  CAS  Google Scholar 

  122. Barnes CA, Elsaesser A, Arkusz J, Smok A, Palus J, Lesniak A, Salvati A, Hanrahan JP, de Jong WH, Dziubaltowska E, Stepnik M, Rydzynski K, McKerr G, Lynch I, Dawson KA, Howard CV (2008) Nano Lett 8:3069–3074

    Article  CAS  Google Scholar 

  123. Jin YH, Kannan S, Wu M, Zhao JXJ (2007) Chem Res Toxicol 20:1126–1133

    Article  CAS  Google Scholar 

  124. Wang JJ, Sanderson BJS, Wang H (2007) Environ Mol Mutagen 48:151–157

    Article  CAS  Google Scholar 

  125. Lee SW, Kim SM, Choi J (2009) Environ Toxicol Pharmacol 28:86–91

    Article  CAS  Google Scholar 

  126. Kim YJ, Choi HS, Song MK, Youk DY, Kim JH, Ryu JC (2009) Molecul Cell Toxicol 5:172–178

    Google Scholar 

  127. Balasubramanyam A, Sailaja N, Mahboob M, Rahman MF, Hussain SM, Grover P (2009) Mutagenesis 24:245–251

    Article  CAS  Google Scholar 

  128. Pierscionek BK, Li YB, Yasseen AA, Colhoun LM, Schachar RA, Chen W (2010) Nanotechnology 21:035102

    Article  CAS  Google Scholar 

  129. Rothen-Rutishauser B, Grass RN, Blank F, Limbach LK, Muehlfeld C, Brandenberger C, Raemy DO, Gehr P, Stark WJ (2009) Environ Sci Technol 43:2634–2640

    Article  CAS  Google Scholar 

  130. Auffan M, Rose J, Orsiere T, Meo MD, Thill A, Zeyons O, Proux O, Masion A, Chaurand P, Spalla O, Botta A, Wiesner MR, Bottero JY (2009) Nanotoxicology 3:161–171

    Article  CAS  Google Scholar 

  131. Stone V, Johnston H, Schins RPF (2009) Crit Rev Toxicol 39:613–626

    Article  CAS  Google Scholar 

  132. Fahmy B, Cormier SA (2009) Toxicol In Vitro 23:1365–1371

    Article  CAS  Google Scholar 

  133. Auffan M, Decome L, Rose J, Orsiere T, De Meo M, Briois V, Chaneac C, Olivi L, Berge-Lefranc JL, Botta A, Wiesner MR, Bottero JY (2006) Environ Sci Technol 40:4367–4373

    Article  CAS  Google Scholar 

  134. Bhattacharya K, Davoren M, Boertz J, Schins RPF, Hoffmann E, Dopp E (2009) Part Fibre Toxicol 6:17

    Article  CAS  Google Scholar 

  135. Petrat F, Paluch S, Dogruoz E, Dorfler P, Kirsch M, Korth HG (2003) J Biol Chem 278:46403–46413

    Article  CAS  Google Scholar 

  136. Dunford R, Salinaro A, Cai L, Serpone N, Horikoshi S, Hidaka H, Knowland J (1997) FEBS Lett 418:87–90

    Article  CAS  Google Scholar 

  137. Gottschalk F, Sonderer T, Scholz RW, Nowack B (2009) Environ Sci Technol 43:9216–9222

    Article  CAS  Google Scholar 

  138. Mueller NC, Nowack B (2008) Environ Sci Technol 42:4447–4453

    Article  CAS  Google Scholar 

  139. Hirakawa K, Mori M, Yoshida M, Oikawa S, Kawanishi S (2004) Free Radic Res 38:439–447

    Article  CAS  Google Scholar 

  140. Kemp TJ, McIntyre RA (2007) Prog React Kinet Mech 32:219–229

    Article  CAS  Google Scholar 

  141. Nakagawa Y, Wakuri S, Sakamoto K, Tanaka K (1997) Mutat Res 394:125–132

    CAS  Google Scholar 

  142. Reeves JF, Davies SJ, Dodd NJF, Jha AN (2008) Mutat Res 640:113–122

    CAS  Google Scholar 

  143. Serpone N, Salinaro AE, Horikoshi S, Hidaka H (2006) J Photochem Photobiol A 179:200–212

    Article  CAS  Google Scholar 

  144. Vevers WF, Jha AN (2008) Ecotoxicology 17:410–420

    Article  CAS  Google Scholar 

  145. Zhu RR, Wang SL, Chao J, Shi DL, Zhang R, Sun XY, Yao SD (2009) Mater Sci Eng C 29:691–696

    Article  CAS  Google Scholar 

  146. Gopalan RC, Osman IF, Amani A, Matas MD, Anderson D (2009) Nanotoxicology 3:33–39

    Article  CAS  Google Scholar 

  147. Huang NP, Xu MH, Yuan CW, Yu RR (1997) J Photochem Photobiol A 108:229–233

    Article  CAS  Google Scholar 

  148. Falck GCM, Lindberg HK, Suhonen S, Vippola M, Vanhala E, Catalan J, Savolainen K, Norppa H (2009) Hum Exp Toxicol 28:339–352

    Article  CAS  Google Scholar 

  149. Kang SJ, Kim BM, Lee YJ, Chung HW (2008) Environ Mol Mutagen 49:399–405

    Article  CAS  Google Scholar 

  150. Wang JJ, Sanderson BJS, Wang H (2007) Mutat Res Genet Toxicol Environ Mutagen 628:99–106

    Article  CAS  Google Scholar 

  151. Sato T, Taya M (2006) Biochem Eng J 28:303–308

    Article  CAS  Google Scholar 

  152. Dodd NJF, Jha AN (2009) Mutat Res Fundam Molecul Mech Mutagen 660:79–82

    Article  CAS  Google Scholar 

  153. Rehn B, Seiler F, Rehn S, Bruch J, Maier M (2003) Toxicol Appl Pharmacol 189:84–95

    Article  CAS  Google Scholar 

  154. Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiestl RH (2009) Cancer Res 69:8784–8789

    Article  CAS  Google Scholar 

  155. Lin WS, Xu Y, Huang CC, Ma YF, Shannon KB, Chen DR, Huang YW (2009) J Nanopart Res 11:25–39

    Article  CAS  Google Scholar 

  156. Sharma V, Shukla RK, Saxena N, Parmar D, Das M, Dhawan A (2009) Toxicol Lett 185:211–218

    Article  CAS  Google Scholar 

  157. Mahendra S, Zhu HG, Colvin VL, Alvarez PJ (2008) Environ Sci Technol 42:9424–9430

    Article  CAS  Google Scholar 

  158. Green M, Howman E (2005) Chem Commun 121–123

  159. Hoshino A, Fujioka K, Oku T, Suga M, Sasaki YF, Ohta T, Yasuhara M, Suzuki K, Yamamoto K (2004) Nano Lett 4:2163–2169

    Article  CAS  Google Scholar 

  160. Anas A, Akita H, Harashima H, Itoh T, Ishikawa M, Biju V (2008) J Phys Chem B 112:10005–10011

    Article  CAS  Google Scholar 

  161. Mottley C, Harman LS, Mason RP (1985) Biochem Pharmacol 34:3005–3008

    Article  CAS  Google Scholar 

  162. Gagne F, Auclair J, Turcotte P, Fournier M, Gagnon C, Sauve S, Blaise C (2008) Aquat Toxicol 86:333–340

    Article  CAS  Google Scholar 

  163. Gagne F, Maysinger D, Andre C, Blaise C (2008) Nanotoxicology 2:113–120

    Article  CAS  Google Scholar 

  164. Badisa VLD, Latinwo LM, Odewumi CO, Ikediobi CO, Badisa RB, Ayuk-Takem LT, Nwoga J, West J (2007) Environ Toxicol 22:144–151

    Article  CAS  Google Scholar 

  165. Faverney CR, Devaux A, Lafaurie M, Girard JP, Bailly B, Rahmani R (2001) Aquat Toxicol 53:65–76

    Article  Google Scholar 

  166. Hossain Z, Huq F (2002) J Inorg Biochem 90:85–96

    Article  CAS  Google Scholar 

  167. Prakash AS, Rao KS, Dameron CT (1998) Biochem Biophys Res Commun 244:198–203

    Article  CAS  Google Scholar 

  168. Dizdaroglu M (1998) Free Radic Res 29:551–563

    Article  CAS  Google Scholar 

  169. ESCODD (2003) Free Radic Biol Med 34:1089–1099

    Article  CAS  Google Scholar 

  170. Park H, Grassian VH (2010) Environ Toxicol Chem 29:715–721

    Article  CAS  Google Scholar 

  171. Doak SH, Griffiths SM, Manshian B, Singh N, Williams PM, Brown AP, Jenkins GJS (2009) Mutagenesis 24:285–293

    Article  CAS  Google Scholar 

  172. Sayes CM, Marchione AA, Reed KL, Warheit DB (2007) Nano Lett 7:2399–2406

    Article  CAS  Google Scholar 

  173. Rakiman I, Chinnadurai M, Baraneedharan U, Paul SFD, Venkatachalam P (2008) Adv Biotechnol 7:39–41

    Google Scholar 

Download references

Acknowledgements

The authors would like to thank Miral Dizdaroglu (NIST) for carefully reviewing the manuscript during its preparation and Jerry Rattanong (Georgetown University) for editorial assistance.

Disclaimer

Certain commercial equipment, instruments, and materials are identified to specify experimental procedures as completely as possible. In no case does such identification imply a recommendation or endorsement by the NIST nor does it imply that any of the materials, instruments, or equipment identified are necessarily the best available for the purpose.

Author information

Authors and Affiliations

  1. Chemical Science and Technology Laboratory, Biochemical Science Division, National Institute of Standards and Technology, 100 Bureau Drive, Stop 8311, Gaithersburg, MD, 20899-0001, USA

    Elijah J. Petersen & Bryant C. Nelson

Authors
  1. Elijah J. Petersen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bryant C. Nelson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bryant C. Nelson.

Electronic supplementary material

Below is the link to the electronic supplementary material.

ESM 1

(PDF 503 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Petersen, E.J., Nelson, B.C. Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA. Anal Bioanal Chem 398, 613–650 (2010). https://doi.org/10.1007/s00216-010-3881-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-010-3881-7

Keywords

Search

Navigation