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Trends in solid-state NMR spectroscopy and their relevance for bioanalytics

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Abstract

Based on continuous methodical advances and developments, solid-state NMR spectroscopy has become a powerful tool for the investigation of various materials, including polymers, glasses, zeolites, fullerenes, and many others. During the past decade, solid-state NMR spectroscopy also found increasing interest for the study of biomolecules. For example, membrane proteins reconstituted into lipid environments such as bilayers or vesicles, protein aggregates such as amyloid fibrils, as well as carbohydrates can now be studied by solid-state NMR spectroscopy. This review briefly introduces the principles of solid-state NMR spectroscopy and highlights novel methodical trends. Selected applications demonstrate the possibilities of solid-state NMR spectroscopy as a valuable bioanalytical tool.

Trends in solid-state NMR spectroscopy

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Acknowledgements

The authors wish to thank Annett Bachmann and Renate Schulze for carefully proofreading the manuscript. Financial support from the Deutsche Forschungsgemeinschaft (BR 1278/ 12) is gratefully acknowledged.

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  1. Fachrichtung Chemie und Lebensmittelchemie, Bioanalytische Chemie, TU Dresden, 01062, Dresden, Germany

    Silvia Paasch & Eike Brunner

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  1. Silvia Paasch
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Correspondence to Eike Brunner.

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Published in the special issue on Focus on Bioanalysis with Guest Editors Antje J. Baeumner, Günter Gauglitz, and Frieder W. Scheller.

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Paasch, S., Brunner, E. Trends in solid-state NMR spectroscopy and their relevance for bioanalytics. Anal Bioanal Chem 398, 2351–2362 (2010). https://doi.org/10.1007/s00216-010-4037-5

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