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Selective recognition of a saccharide-type tumor marker with natural and synthetic ligands: a new trend in cancer diagnosis

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Abstract

It is well known that saccharides and their glycoconjugates can have an important influence on various serious pathologic stages such as cancer. They can regulate tumor proliferation, invasion, hematogenous metastasis, and angiogenesis. These facts clearly show the importance of cancer saccharide recognition. In medicine, sensor analysis is one of the best methods for recognition and determination of biologically important analytes. The development and study of sensors for saccharide tumor markers can open a new way for their detection. Therefore, this review is focused on recognition of saccharide-based cancer markers by natural or synthetic selective ligands working as bio- and chemosensors. The design and application of these ligands for cancer diagnosis is a useful direction of research. Moreover, it also opens the possibility of using these agents for the targeted drug transport required for advanced anticancer therapy.

Boronic acid sensor [56]

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Acknowledgements

This work was supported by grants from the Ministry of Education of the Czech Republic (grants MSMT 1M 6837805002, MSM6036137307, MSM0021620857, AV0Z50520514; projects LC512, LC06077, and MSM6036137307) and from the Grant Agency of the Czech Republic (grant 203/09/1311) and, in part, by project AV0Z50520514 and grant KAN200200651 awarded by the Grant Agency of the Academy of Sciences of the Czech Republic.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemical Engineering, Institute of Chemical Technology, Technická 5, 166 28, Prague 6, Czech Republic

    Zdeněk Kejík, Tomáš Bříza & Vladimír Král

  2. First Faculty of Medicine, Charles University in Prague, Katerinska 32, 121 08, Prague 2, Czech Republic

    Zdeněk Kejík, Tomáš Bříza & Pavel Martásek

  3. Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnská 1083, 142 20, Prague 4, Czech Republic

    Jarmila Králová

  4. Zentiva k.s (Part of the sanofi-aventis group), U Kabelovny 130, 10237, Prague 10, Czech Republic

    Vladimír Král

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  1. Zdeněk Kejík
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  2. Tomáš Bříza
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  3. Jarmila Králová
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  4. Pavel Martásek
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  5. Vladimír Král
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Correspondence to Zdeněk Kejík.

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Published in the special issue Optical Biochemical and Chemical Sensors (Europtrode X) with guest editor Jiri Homola.

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Kejík, Z., Bříza, T., Králová, J. et al. Selective recognition of a saccharide-type tumor marker with natural and synthetic ligands: a new trend in cancer diagnosis. Anal Bioanal Chem 398, 1865–1870 (2010). https://doi.org/10.1007/s00216-010-4124-7

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  • DOI: https://doi.org/10.1007/s00216-010-4124-7

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