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Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species

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Abstract

The fact that the essential or toxic character of elements is species specific has encouraged the development of analytical strategies for chemical speciation over the last twenty years; indeed, there are now a great number of them that provide very good performance. However, biological systems are exposed to a complex environment in which species of elements can interact in a synergistic/antagonistic fashion. Thus, the metabolism of trace elements cannot be considered in isolation. On the other hand, biological systems are dynamic, so it is necessary to study the trafficking of species of elements between organs, tissues or cell compartments in order to decipher the biochemical processes of the interactions in which they are involved. Although the application of liquid chromatography–inductively coupled plasma-based “metallomics” methods in combination with organic mass spectrometry can provide much-needed insight, new analytical strategies are required to really understand the role of species of elements in biological systems and the mechanisms of their interactions. In the present paper, the interactions of the most widely studied elements in this context (Se, Hg and As) are discussed, as well as other important interactions between different elements.

Interactions of chemical species in biology

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Abbreviations

APS:

ATP sulfurylase/adenyl sulfate reductase

APSe-5′:

Adenylylselenate

CE:

Capillary electrophoresis

DMA:

Dimethylarsinate

ESI:

Electrospray ionization

GPx:

Glutathione peroxidase

HPLC:

High-performance liquid chromatography

IC:

Ion chromatography

ICP-AES:

Inductively coupled plasma atomic emission spectroscopy

ICP-MS:

Inductively coupled plasma mass spectrometry

MS:

Mass spectrometry

MALDI:

Matrix-assisted laser desorption ionization

MeHg+ :

Methylmercury

MA:

Methylarsonate

PheHg+ :

Phenylmercury

SeBet:

Selenobetaine

SeMet:

Selenomethionine

SeProt:

Selenoproteins

TlAc:

Thallium acetate

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Acknowledgments

This work was supported by the project CTM2009-12858-C02-01 from the Spanish Ministry of Science and Education, and the projects P08-FQM-03554 and P09-FQM-4659 from the Innovation, Science and Enterprise Agency (Andalusian Government). M. González-Fernández thanks the Spanish Ministry of Education/Ministry of Science and Innovation (Campus of Excellence—CiA3 Program) for a postdoctoral grant. M.A. García Sevillano thanks the Ministry of Education for a Ph.D. scholarship (FPU). V. Gómez-Jacinto thanks the Ministry of Innovation and Science for a Ph.D. grant.

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  1. Department of Chemistry and Materials Science, Faculty of Experimental Sciences, University of Huelva, 21007, Huelva, Spain

    T. García-Barrera, J. L. Gómez-Ariza, M. González-Fernández, F. Moreno, M. A. García-Sevillano & V. Gómez-Jacinto

  2. Campus of Excellence CiA3, University of Huelva, 21007, Huelva, Spain

    T. García-Barrera, J. L. Gómez-Ariza, M. González-Fernández, F. Moreno, M. A. García-Sevillano & V. Gómez-Jacinto

  3. Research Center of Health and Environment (CYSMA), University of Huelva, 21007, Huelva, Spain

    T. García-Barrera, J. L. Gómez-Ariza, M. González-Fernández, F. Moreno, M. A. García-Sevillano & V. Gómez-Jacinto

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Published in the special issue Young Investigators in Analytical and Bioanalytical Science with guest editors S. Daunert, J. Bettmer, T. Hasegawa, Q. Wang and Y. Wei.

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García-Barrera, T., Gómez-Ariza, J.L., González-Fernández, M. et al. Biological responses related to agonistic, antagonistic and synergistic interactions of chemical species. Anal Bioanal Chem 403, 2237–2253 (2012). https://doi.org/10.1007/s00216-012-5776-2

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