Abstract
The worldwide increase in the number of people suffering from diabetes has been the driving force for the development of glucose sensors. The recent past has devised various approaches to formulate glucose sensors using various nanostructure materials. This review presents a combined survey of these various approaches, with emphasis on the current progress in the use of electrospun nanofibers and their composites. Outstanding characteristics of electrospun nanofibers, including high surface area, porosity, flexibility, cost effectiveness, and portable nature, make them a good choice for sensor applications. Particularly, their nature of possessing a high surface area makes them the right fit for large immobilization sites, resulting in increased interaction with analytes. Thus, these electrospun nanofiber-based glucose sensors present a number of advantages, including increased life time, which is greatly needed for practical applications. Taking all these facts into consideration, we have highlighted the latest significant developments in the field of glucose sensors across diverse approaches.
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References
Lin Y, Yu P, Hao J, Wang Y, Ohsaka T, Mao L (2014) Continuous and simultaneous electrochemical measurements of glucose, lactate, and ascorbate in rat brain following brain ischemia. Anal Chem 86:3895–3901
Odaci D, Gacal BN, Gacal B, Timur S, Yagci Y (2009) Fluorescence sensing of glucose using glucose oxidase modified by PVA-pyrene prepared via “click” chemistry. Biomacromolecules 10:2928–2934
Kropff J, Bruttomesso D, Doll W, Farret A, Galasso S, Luijf YM, Mader JK, Place J, Boscari F, Pieber TR, Renard E, DeVries JH (2015) Accuracy of two continuous glucose monitoring systems: to-head comparison under clinical research centre and daily life. Diabetes Obes Metab 17:343–349
Benassi K, Drobny J, Aye T (2013) Real-time continuous glucose monitoring systems in the classroom/school environment. Diabetes Technol Ther 15:409–412
Diagnosing Diabetes and Learning About Prediabetes. American Diabetes Association. Available at: http://www.diabetes.org/diabetes-basics/diagnosis/?loc=db-slabnav. Accessed 12 September 2015
International Diabetic Federation (2013) Annual report. 1–37. Available at: http://www.idf.org/sites/default/files/attachments/IDF-AR2013-final-rv.pdf. Accessed 12 September 2015
Clark LC Jr, Lyons C (1962) Electrode systems for continuous monitoring in cardiovascular surgery. Ann NY Acad Sci 102:29–45
Updike SJ, Hicks GP (1967) The enzyme electrode. Nature 214:986–988
McNichols RJ, Coté GL (2000) Optical glucose sensing in biological fluids: an overview. J Biomed Opt 5:5–16
Endo T, Ikeda R, Yanagida Y, Hatsuzawa T (2008) Stimuli-responsive hydrogel-silver nanoparticles composite for development of localized surface plasmon resonance-based optical biosensor. Anal Chim Acta 611:205–211
Steiner M-S, Duerkop A, Wolfbeis OS (2011) Optical methods for sensing glucose. Chem Soc Rev 40:4805–4839
Barone PW, Strano MS (2009) Single walled carbon nanotubes as reporters for the optical detection of glucose. J Diabetes Sci Technol 3:242–252
Zhou YG, Yang S, Qian QY, Xia XH (2009) Gold nanoparticles integrated in a nanotube array for electrochemical detection of glucose. Electrochem Commun 11:216–219
Wang J, Thomas DF, Chen A (2008) Nonenzymatic electrochemical glucose sensor based on nanoporous PtPb networks. Anal Chem 80:997–1004
Su C, Zhang C, Lu G, Ma C (2010) Nonenzymatic electrochemical glucose sensor based on Pt nanoparticles/mesoporous carbon matrix. Electroanalysis 22:1901–1905
Li H, Liu S, Dai Z, Bao J, Yang X (2009) Applications of nanomaterials in electrochemical enzyme biosensors. Sensors 9:8547–8561
du Toit H, Di Lorenzo M (2014) Glucose oxidase directly immobilized onto highly porous gold electrodes for sensing and fuel cell applications. Electrochim Acta 138:86–92
Wang Y, Liu L, Li M, Xu S, Gao F (2011) Multifunctional carbon nanotubes for direct electrochemistry of glucose oxidase and glucose bioassay. Biosens Bioelectron 30:107111
Cui HF, Zhang K, Zhang YF, Sun YL, Wang J, Zhang WD, Luong JHT (2013) Immobilization of glucose oxidase into a nanoporous TiO2 film layered on metallophthalocyanine modified vertically-aligned carbon nanotubes for efficient direct electron transfer. Biosens Bioelectron 46:113–118
Si P, Huang Y, Wang T, Ma J (2013) Nanomaterials for electrochemical nonenzymatic glucose biosensors. RSC Adv 3:3487–3502
Pradhan D, Niroui F, Leung KT (2010) High-performance, flexible enzymatic glucose biosensor based on ZnO nanowires supported on a gold-coated polyester substrate. ACS Appl Mater Interfaces 2:2409–2412
Yang X, Bai J, Wang Y, Jiang X, He X (2012) Hydrogen peroxide and glucose biosensor based on silver nanowires synthesized by polyol process. Analyst 137:4362–4367
Cherevko S, Chung CH (2009) Gold nanowire array electrode for nonenzymatic voltammetric and amperometric glucose detection. Sensors Actuators B Chem 142:216–223
Tarlani A, Fallah M, Lotfi B, Khazraei A, Golsanamlou S, Muzart J, Mirza-Aghayan M (2015) New ZnO nanostructures as nonenzymatic glucose biosensors. Biosens Bioelectron 67:601–607
Claussen JC, Kim SS, Haque AU, Artiles MS, Porterfield DM, Fisher TS (2010) Electrochemical glucose biosensor of platinum nanospheres connected by carbon nanotubes. J Diabetes Sci Technol 4:312–319
Alwarappan S, Liu C, Kumar A, Li CZ (2010) Enzyme-doped graphene nanosheets for enhanced glucose biosensing. J Phys Chem C 114:12920–12924
Ding Y, Wang Y, Su L, Bellagamba M, Zhang H, Lei Y (2010) Electrospun Co3O4 nanofibers for sensitive and selective glucose detection. Biosens Bioelectron 26:542–548
Li Z, Xin Y, Zhang Z, Wu H, Wang P (2015) Rational design of binder-free noble metal/metal oxide arrays with nanocauliflower structure for wide linear range nonenzymatic glucose detection. Sci Rep 5:10617
Huang S, Ding Y, Liu Y, Su L, Filosa R, Lei Y (2011) Glucose biosensor using glucose oxidase and electrospun Mn2O3-Ag nanofibers. Electroanalysis 23:1912–1920
Scampicchio M, Arecchi A, Lawrence NS, Mannino S (2010) Nylon nanofibrous membrane for mediated glucose biosensing. Sensors Actuators B Chem 145:394–397
Umar A, Rahman MM, Al-Hajry A, Hahn YB (2009) Enzymatic glucose biosensor based on flower-shaped copper oxide nanostructures composed of thin nanosheets. Electrochem Commun 11:278–281
Wang X, Hu C, Liu H, Du G, He X, Xi Y (2010) Synthesis of CuO nanostructures and their application for nonenzymatic glucose sensing. Sensors Actuators B Chem 144:220–225
Zhang Y, Wang Y, Jia J, Wang J (2012) Nonenzymatic glucose sensor based on graphene oxide and electrospun NiO nanofibers. Sensors Actuators B Chem 171(172):580–587
Zhang Y, Liu S, Li Y, Deng D, Si X, Ding Y, He H, Luo L, Wang Z (2015) Electrospun graphene decorated MnCo2O4 composite nanofibers for glucose biosensing. Biosens Bioelectron 66:308–315
Wang ZG, Wang Y, Xu H, Li G, Xu ZK (2009) Carbon nanotube-filled nanofibrous membranes electrospun from poly(acrylonitrile-co-acrylic acid) for glucose biosensor. J Phys Chem C 113:2955–2960
Manesh KM, Kim HT, Santhosh P, Gopalan AI, Lee KP (2008) A novel glucose biosensor based on immobilization of glucose oxidase into multiwall carbon nanotubes-polyelectrolyte-loaded electrospun nanofibrous membrane. Biosens Bioelectron 23:771–779
Bai Y, Yang H, Yang W, Li Y, Sun C (2007) Gold nanoparticles-mesoporous silica composite used as an enzyme immobilization matrix for amperometric glucose biosensor construction. Sensors Actuators B Chem 124:179–186
Zhao L, Wu G, Cai Z, Zhao T, Yao Q, Chen X (2015) Ultrasensitive nonenzymatic glucose sensing at near-neutral pH values via anodic stripping voltammetry using a glassy carbon electrode modified with Pt3Pd nanoparticles and reduced graphene oxide. Microchim Acta 182:2055–2060
Solanki PR, Kaushik A, Agrawal VV, Malhotra BD (2011) Nanostructured metal oxide-based biosensors. NPG Asia Mater 3:17–24
Cash KJ, Clark HA (2010) Nanosensors and nanomaterials for monitoring glucose in diabetes. Trends Mol Med 16:584–593
Nitinaivinij K, Parnklang T, Thammacharoen C, Ekgasita S, Wongravee K (2014) Colorimetric determination of hydrogen peroxide by morphological decomposition of silver nanoprisms coupled with chromaticity analysis. Anal Methods 6:9816–9824
Rahman MM, Ahammad AJS, Jin JH, Ahn SJ, Lee JJ (2010) A comprehensive review of glucose biosensors based on nanostructured metal-oxides. Sensors 10:4855–4886
Senthamizhan A, Celebioglu A, Uyar T (2015) Ultrafast on-site selective visual detection of TNT at sub-ppt level using fluorescent gold cluster incorporated single nanofiber. Chem Commun 51:5590–5593
Senthamizhan A, Celebioglu A, Uyar T (2014) Flexible and highly stable electrospun nanofibrous membrane incorporating gold nanoclusters as an efficient probe for visual colorimetric detection of Hg(II). J Mater Chem A 2:12717–12723
Nakabayashi Y, Hirosaki Y, Yamauchi O (2006) Dipolar ruthenium–ammine complexes with 4,4'-bipyridinium ions accessible for both amperometric and colorimetric glucose sensors. Inorg Chem Commun 9:935–938
Zhou B, Wang J, Guo Z, Tan H, Zhu X (2006) A simple colorimetric method for determination of hydrogen peroxide in plant tissues. Plant Growth Regul 49:113–118
Chigome S, Torto N (2011) A review of opportunities for electrospun nanofibers in analytical chemistry. Anal Chim Acta 706:25–36
Ondigo DA, Tshentu ZR, Torto N (2013) Electrospun nanofibe-based colorimetric probe for rapid detection of Fe2+ in water. Anal Chim Acta 804:228–234
Mudabuka B, Ondigo D, Degni S, Vilakazi S, Torto N (2014) A colorimetric probe for ascorbic acid based on copper-gold nanoparticles in electrospun nylon. Microchim Acta 181:395–401
Wang X, Si Y, Wang J, Ding B, Yu J, Al-Deyab SS (2012) A facile and highly sensitive colorimetric sensor for the detection of formaldehyde based on electro-spinning/netting nano-fiber/nets. Sensors Actuators B Chem 163:186–193
Gao F, Luo F, Chen X, Yao W, Yin J, Yao Z, Wang L (2009) A novel nonenzymatic fluorescent sensor for glucose based on silica nanoparticles doped with europium coordination compound. Talanta 80:202–206
Kochubey VI, Volkova EK, Konyukhova JG (2014) Fluorescent ZnCdS nanoparticles for glucose sensing. J Biomed Opt 19:011020
Li J, Li Y, Shahzad SA, Chen J, Chen Y, Wang Y, Yang M, Yu C (2015) Fluorescence turn-on detection of glucose via the Ag nanoparticle mediated release of a perylene probe. Chem Commun 51:6354–6356
Ding B, Yu J (2014) Electrospun nanofibers for energy and environmental applications. Springer, Berlin, Germany
Senthamizhan A, Celebioglu A, Bayir S, Gorur M, Doganci E, Yilmaz F, Uyar T (2015) Highly fluorescent pyrene-functional polystyrene copolymer nanofibers for enhanced sensing performance of TNT. ACS Appl Mater Interfaces. doi:10.1021/acsami.5b07184
Thavasi V, Singh G, Ramakrishna S (2008) Electrospun nanofibers in energy and environmental applications. Energy Environ Sci 1:205–221
Fang J, Niu H, Lin T, Wang X (2008) Applications of electrospun nanofibers. Chin Sci Bull 53:2265–2286
Celebioglu A, Umu OC, Tekinay T, Uyar T (2013) Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes. Colloids Surf B: Biointerfaces 116:612–619
Uyar T, Havelund R, Nur Y, Balan A, Hacaloglu J, Toppare L, Besenbacher F, Kingshott P (2010) Cyclodextrin functionalized poly(methyl methacrylate) (PMMA) electrospun nanofibers for organic vapors waste treatment. J Membr Sci 365:409–417
Anitha S, Brabu B, Rajesh KP, Natarajan TS (2013) Fabrication of UV sensor based on electrospun composite fibers. Mater Lett 92:417–420
Anitha S, Brabu B, Thiruvadigal DJ, Gopalakrishnan C, Natarajan TS (2013) Optical, bactericidal, and water repellent properties of electrospun nano-composite membranes of cellulose acetate and ZnO. Carbohydr Polym 97:856–863
Anitha S, Brabu B, Thiruvadigal DJ, Gopalakrishnan C, Natarajan TS (2012) Preparation of free-standing electrospun composite ZnO membranefor antibacterial applications. Adv Sci Lett 5:468–477
Senthamizhan A, Uyar T (2015) In: Macagnano A, Zampetti E, Kny E (eds) Electrospinning for high performance sensors, 1st edn. Springer International Publishing, Switzerland
Hu X, Liu S, Zhou G, Huang Y, Xie Z, Jing X (2014) Electrospinning of polymeric nanofibers for drug delivery applications. J Control Release 185:12–21
Dong Z, Kennedy SJ, Wu Y (2011) Electrospinning materials for energy-related applications and devices. J Power Sources 196:4886–4904
Senthamizhan A, Celebioglu A, Balusamy B, Uyar T (2015) Immobilization of gold nanoclusters inside porous electrospun fibers for selective detection of Cu(II): a strategic approach to shielding pristine performance. Sci Rep 5:15608
Wang ZG, Wan LS, Liu ZM, Huang XJ, Xu ZK (2009) Enzyme immobilization on electrospun polymer nanofibers: an overview. J Mol Catal B Enzym 56:189–195
Wang J (2008) Electrochemical glucose biosensors. Chem Rev 108:814–825
Heller A, Feldman B (2008) Electrochemical glucose sensors and their applications in diabetes management. Chem Rev 108:2482–2505
Song C, Pehrsson PE, Zhao W (2006) Optical enzymatic detection of glucose based on hydrogen peroxide-sensitive HiPco carbon nanotubes. J Mater Res 21:2817–2823
Cheng Z, Wang E, Yang X (2001) Capacitive detection of glucose using molecularly imprinted polymers. Biosens Bioelectron 16:179–185
Nakamura H, Mogi Y, Akimoto T, Naemura K, Kato T, Yano K, Karube I (2008) An enzyme-chromogenic surface plasmon resonance biosensor probe for hydrogen peroxide determination using a modified Trinder's reagent. Biosens Bioelectron 24:455–460
Sophia J, Muralidharan G (2015) Gold nanoparticles for sensitive detection of hydrogen peroxide: a simple nonenzymatic approach. J Appl Electrochem 45:963–971
Tura A, Sbrignadello S, Cianciavicchia D, Pacini G, Ravazzani P (2010) A low frequency electromagnetic sensor for indirect measurement of glucose concentration: in vitro experiments in different conductive solutions. Sensors 10:5346–5358
Gourzi M, Rouane A, Guelaz R, Alavi MS, McHugh MB, Nadi M, Roth P (2005) Noninvasive glycaemia blood measurements by electromagnetic sensor: study in static and dynamic blood circulation. J Med Eng Technol 29:22–26
Wilson R, Turner APF (1992) Glucose oxidase: an ideal enzyme. Biosens Bioelectron 7:165–185
Al-Halhouli A, Demming S, Alahmad L, LIobera A, Büttgenbach S (2014) An in-line photonic biosensor for monitoring of glucose concentrations. Sensors 14:15749–15759
Park S, Boo H, Chung TD (2006) Electrochemical nonenzymatic glucose sensors. Anal Chim Acta 556:46–57
Clark L Jr (1970) US Patent 33,539,455
Chen C, Xie Q, Yang D, Xiao H, Fu Y, Tan Y, Yao S (2013) Recent advances in electrochemical glucose biosensors: a review. RSC Adv 3:4473–4491
Saleh FS, Mao L, Ohsaka T (2012) A promising dehydrogenase-based bioanode for a glucose biosensor and glucose/O2 biofuel cell. Analyst 137:2233–2238
Yehezkeli O, Tel-Vered R, Raichlin S, Willner I (2011) Nano-engineered flavin-dependent glucose dehydrogenase/gold nanoparticle-modified electrodes for glucose sensing and biofuel cell applications. ACS Nano 5:2385–2391
Zayats M, Katz E, Baron R, Willner I (2005) Reconstitution of apo-glucose dehydrogenase on pyrroloquinoline quinone-functionalized Au nanoparticles yields an electrically contacted biocatalyst. J Am Chem Soc 127:12400–12406
Zafar MN, Wang X, Sygmund C, Ludwig R, Leech D, Gorton L (2012) Electron-transfer studies with a new flavin adenine dinucleotide-dependent glucose dehydrogenase and osmium polymers of different redox potentials. Anal Chem 84:334–341
Lewis BE, Schramm VL (2003) Binding equilibrium isotope effects for glucose at the catalytic domain of human brain hexokinase. J Am Chem Soc 125:4785–4798
Anicet N, Bourdillon C, Moiroux J, Savéant JM (1999) Step-by-step avidin-biotin construction of bienzyme electrodes. Kinetic analysis of the coupling between the catalytic activities of immobilized monomolecular layers of glucose oxidase and hexokinase. Langmuir 15:6527–6533
Bunte C, Prucker O, König T, Rühe J (2010) Enzyme containing redox polymer networks for biosensors or biofuel cells: a photochemical approach. Langmuir 26:6019–6027
Toghill KE, Compton RG (2010) Electrochemical nonenzymatic glucose sensors: a perspective and an evaluation. Int J Electrochem Sci 5:1246–1301
Cass AEG, Davis G, Francis GD, Hill HAO, Aston WJ, Higgins IJ, Plotkin EV, Scott LDL, Turner APF (1984) Ferrocene-mediated enzyme electrode for amperometric determination of glucose. Anal Chem 56:667–671
Tsujimura S, Kojima S, Kano K, Ikeda T, Sato M, Sanada H, Omura H (2006) Novel FAD-dependent glucose dehydrogenase for a dioxygen-insensitive glucose biosensor. Biosci Biotechnol Biochem 70:654–659
Lau KT, De Fortescu SAL, Murphy LJ, Slater JM (2003) Disposable glucose sensors for flow injection analysis using substituted 1,4-benzoquinone mediators. Electroanalysis 15:975–981
Taylor C, Kenausis G, Katakis I, Heller A (1995) “Wiring” of glucose oxidase within a hydrogel made with polyvinyl imidazole complexed with [(Os-4,4′-dimethoxy-2,2′-bipyridine)Cl]+/2+1. J Electroanal Chem 396:511–515
Katakis I, Dominguez E (1995) Characterization and stabilization of enzyme biosensors. Trends Anal Chem 14:310–319
Schugerl K, Hitzmann B, Jurgens H, Kullick T, Ulber R, Weigal B (1996) Challenges in integrating biosensors and FIA for on-line monitoring and control. Trends Biotechnol 14:21–31
Li J, Lin X (2007) Glucose biosensor based on immobilization of glucose oxidase in poly(o-aminophenol) film on polypyrrole-Pt nanocomposite modified glassy carbon electrode. Biosens Bioelectron 22:2898–2905
Loeb W (1909) Biochem Z 17:132
Luo D, Wu L, Zhi J (2009) Fabrication of boron-doped diamond nanorod forest electrodes and their application in nonenzymatic amperometric glucose biosensing. ACS Nano 3:2121–2128
Gao H, Xiao F, Ching CB, Duan H (2011) One-step electrochemical synthesis of PtNi nanoparticle-graphene nanocomposites for nonenzymatic amperometric glucose detection. ACS Appl Mater Interfaces 3:3049–3057
Tian K, Prestgard M, Tiwari A (2014) A review of recent advances in nonenzymatic glucose sensors. Mater Sci Eng C 41:100–118
Kang X, Mai Z, Zou X, Cai P, Mo J (2008) Glucose biosensors based on platinum nanoparticles-deposited carbon nanotubes in sol-gel chitosan/silica hybrid. Talanta 74:879–886
Feng D, Wang F, Chen Z (2009) Electrochemical glucose sensor based on one-step construction of gold nanoparticle-chitosan composite film. Sensors Actuators B Chem 138:539–544
Bai H, Han M, Du Y, Bao J, Dai Z (2010) Facile synthesis of porous tubular palladium nanostructures and their application in a nonenzymatic glucose sensor. Chem Commun 46:1739–1741
Lu LM, Zhang L, Qu FL, Lu HX, Zhang XB, Wu ZS, Huan SY, Wang QA, Shen GL, Yu RQ (2009) A nano-Ni based ultrasensitive nonenzymatic electrochemical sensor for glucose: enhancing sensitivity through a nanowire array strategy. Biosens Bioelectron 25:218–223
Huang TK, Lin KW, Tung SP, Cheng TM, Chang IC, Hsieh YZ, Lee CY, Chiu HT (2009) Glucose sensing by electrochemically grown copper nanobelt electrode. J Electroanal Chem 636:123–127
Reitz E, Jia W, Gentile M, Wang Y, Lei Y (2008) CuO nanospheres based nonenzymatic glucose sensor. Electroanalysis 20:2482–2486
Dong XC, Xu H, Wang XW, Huang YX, Chan-Park MB, Zhang H, Wang LH, Huang W, Chen P (2012) 3D graphene-cobalt oxide electrode for high-performance supercapacitor and enzymeless glucose detection. ACS Nano 6:3206–3213
Li C, Liu Y, Li L, Du Z, Xu S, Zhang M, Yin X, Wang T (2008) A novel amperometric biosensor based on NiO hollow nanospheres for biosensing glucose. Talanta 77:455–459
Umar A, Rahman MM, Hahn YB (2009) MgO polyhedral nanocages and nanocrystals based glucose biosensor. Electrochem Commun 11:1353–1357
Kong T, Chen Y, Ye Y, Zhang K, Wang Z, Wang X (2009) An amperometric glucose biosensor based on the immobilization of glucose oxidase on the ZnO nanotubes. Sensors Actuators B Chem 138:344–350
Cao X, Wang N (2011) A novel nonenzymatic glucose sensor modified with Fe2O3 nanowire arrays. Analyst 136:4241–4246
Wang X, Zhang Y, Banks CE, Chen Q, Ji X (2010) Nonenzymatic amperometric glucose biosensor based on nickel hexacyanoferrate nanoparticle film modified electrodes. Colloids Surfaces B Biointerfaces 78:363–366
Bai Y, Sun Y, Sun C (2008) Pt-Pb nanowire array electrode for enzyme-free glucose detection. Biosens Bioelectron 24:579–585
Li LH, Zhang WD, Ye JS (2008) Electrocatalytic oxidation of glucose at carbon nanotubes supported PtRu nanoparticles and its detection. Electroanalysis 20:2212–2216
Holt-Hindle P, Nigro S, Asmussen M, Chen A (2008) Amperometric glucose sensor based on platinum-iridium nanomaterials. Electrochem Commun 10:1438–1441
Mahshid SS, Mahshid S, Dolati A, Ghorbani M, Yang L, Luo S, Cai Q (2011) Template-based electrodeposition of Pt/Ni nanowires and its catalytic activity towards glucose oxidation. Electrochim Acta 58:551–555
Ryu J, Kim K, Kim HS, Hahn HT, Lashmore D (2010) Intense pulsed light induced platinum-gold alloy formation on carbon nanotubes for nonenzymatic glucose detection. Biosens Bioelectron 26:602–607
Tominaga M, Shimazoe T, Nagashima M, Taniguchi I (2008) Composition–activity relationships of carbon electrode-supported bimetallic gold-silver nanoparticles in electrocatalytic oxidation of glucose. J Electroanal Chem 615:51–61
Yi Q, Yu W, Niu F (2010) Novel nanoporous binary Au-Ru electrocatalysts for glucose oxidation. Electroanalysis 22:556–563
Chen LY, Fujita T, Ding Y, Chen MW (2010) A three-dimensional gold-decorated nanoporous copper core-shell composite for electrocatalysis and nonenzymatic biosensing. Adv Funct Mater 20:2279–2285
Ni Y, Jin L, Zhanga L, Hong J (2010) Honeycomb-like Ni@C composite nanostructures: synthesis, properties and applications in the detection of glucose and the removal of heavy-metal ions. J Mater Chem 20:6430–6436
Ding Y, Liu Y, Zhang L, Wang Y, Bellagamba M, Parisi J, Li CM, Lei Y (2011) Sensitive and selective nonenzymatic glucose detection using functional NiO-Pt hybrid nanofibers. Electrochim Acta 58:209–214
Zhang X, Gu A, Wang G, Huang Y, Ji H, Fang B (2011) Porous Cu–NiO modified glass carbon electrode enhanced nonenzymatic glucose electrochemical sensors. Analyst 136:5175–5180
Kumar SA, Cheng HW, Chen SM, Wang SF (2010) Preparation and characterization of copper nanoparticles/zinc oxide composite modified electrode and its application to glucose sensing. Mater Sci Eng C 30:86–91
Wang AJ, Feng JJ, Li ZH, Liao QC, Wang ZZ, Chen JR (2012) Solvothermal synthesis of Cu/Cu2O hollow microspheres for nonenzymatic amperometric glucose sensing. Cryst Eng Comm 14:1289
Wang W, Li Z, Zheng W, Yang J, Zhang H, Wang C (2009) Electrospun palladium (IV)-doped copper oxide composite nanofibers for nonenzymatic glucose sensors. Electrochem Commun 11:1811–1814
Luo S, Su F, Liu C, Li J, Liu R, Xiao Y, Li Y, Liu X, Cai Q (2011) A new method for fabricating a CuO/TiO2 nanotube arrays electrode and its application as a sensitive nonenzymatic glucose sensor. Talanta 86:157–163
Ding Y, Wang Y, Zhang L, Zhang H, Lei Y (2012) Preparation, characterization and application of novel conductive NiO–CdO nanofibers with dislocation feature. J Mater Chem 22:980–986
Cao L, Ye J, Tong L, Tang B (2008) A new route to the considerable enhancement of glucose oxidase (GOx) activity: the simple assembly of a complex from CdTe quantum dots and GOx, and its glucose sensing. Chem Eur J 14:9633–9640
Wu P, He Y, Wang HF, Yan XP (2010) Conjugation of glucose oxidase onto Mn-doped Zns quantum dots for phosphorescent sensing of glucose in biological fluids. Anal Chem 82:1427–1433
Sun J, Zhu Y, Yang X, Li C (2009) Photoelectrochemical glucose biosensor incorporating CdS nanoparticles. Particuology 7:347–352
Wang Z, Liu S, Wu P, Cai C (2009) Detection of glucose based on direct electron transfer reaction of glucose oxidase immobilized on highly ordered polyaniline nanotubes. Anal Chem 81:1638–1645
Zenkl G, Mayr T, Klimant I (2008) Sugar-responsive fluorescent nanospheres. Macromol Biosci 8:146–152
Lin LH, Shih JS (2011) Immobilized fullerene C60-enzyme-based electrochemical glucose sensor. J Chin Chem Soc 58:228–235
Zhu Z, Garcia-Gancedo L, Flewitt AJ, Xie H, Moussy F, Milne WI (2012) A critical review of glucose biosensors based on carbon nanomaterials: carbon nanotubes and graphene. Sensors 12:5996–6022
Rathod D, Dickinson C, Egan D, Dempsey E (2010) Platinum nanoparticle decoration of carbon materials with applications in nonenzymatic glucose sensing. Sensors Actuators B Chem 143:547–554
Agarwal S, Greiner A, Wendorff JH (2009) Electrospinning of manmade and biopolymer nanofibers—progress in techniques, materials, and applications. Adv Funct Mater 19:2863–2879
Lu X, Wang C, Wei Y (2009) One-dimensional composite nanomaterials: synthesis by electrospinning and their applications. Small 5:2349–2370
Ramaseshan R, Sundarrajan S, Jose R, Ramakrishna S (2007) Nanostructured ceramics by electrospinning. J Appl Phys 102:111101
Wu H, Pan W, Lin D, Li H (2012) Electrospinning of ceramic nanofibers: fabrication assembly and applications. J Adv Ceram 1:2–23
Celebioglu A, Uyar T (2012) Electrospinning of nanofibers from non-polymeric systems: polymer-free nanofibers from cyclodextrin derivatives. Nanoscale 4:621–631
Fong H, Chun I, Reneker DH (1999) Beaded nanofibers formed during electrospinning. Polymer 40:4585–4592
Casper CL, Stephens JS, Tassi NG, Chase DB, Rabolt JF (2004) Controlling surface morphology of electrospun polystyrene fibers: effect of humidity and molecular weight in the electrospinning process. Macromolecules 37:573–578
Thompson CJ, Chase GG, Yarin AL, Reneker DH (2007) Effects of parameters on nanofiber diameter determined from electrospinning model. Polymer 48:6913–6922
Ramakrishna S, Fujihara K, Teo WE, Lim TC, Ma Z (2005) An introduction to electrospinning and nanofibers. World Scientific Publishing Co. Pte. Ltd, Singapore
Wendorff JH, Agarwal S, Greiner A (2012) Electrospinning: materials, processing, and applications. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany
Greiner A, Wendorff JH (2007) Electrospinning: a fascinating method for the preparation of ultrathin fibers. Angew Chem Int Ed 46:5670–5703
Uyar T, Besenbacher F (2008) Electrospinning of uniform polystyrene fibers: the effect of solvent conductivity. Polymer 49:5336–5343
Celebioglu A, Uyar T (2011) Electrospun porous cellulose acetate fibers from volatile solvent mixture. Mater Lett 65:2291–2294
Persano L, Camposeo A, Tekmen C, Pisignano D (2013) Industrial upscaling of electrospinning and applications of polymer nanofibers: a review. Macromol Mater Eng 298:504–520
Yan G, Yu J, Qiu Y, Yi X, Lu J, Zhou X, Bai X (2011) Self-assembly of electrospun polymer nanofibers: a general phenomenon generating honeycomb-patterned nanofibrous structures. Langmuir 27:4285–4289
Sun B, Long YZ, Zhang HD, Li MM, Duvail JL, Jiang XY, Yin HL (2014) Advances in three-dimensional nanofibrous macrostructures via electrospinning. Prog Polym Sci 39:862–890
Dong H, Wang D, Sun G, Hinestroza JP (2008) Assembly of metal nanoparticles on electrospun nylon 6 nanofibers by control of interfacial hydrogen-bonding interactions. Chem Mater 20:6627–6632
Sahay R, Kumar PS, Sridhar R, Sundaramurthy J, Venugopal J, Mhaisalkar SG, Ramakrishna S (2012) Electrospun composite nanofibers and their multifaceted applications. J Mater Chem 22:12953–12971
Tamaki T, Sugiyama T, Mizoe M, Oshiba Y, Yamaguchi T (2014) Reducing physical adsorption of enzymes by surface modification of carbon black for high-current-density biofuel cells. J Electrochem Soc 161:H3095–H3099
de Luiz MI, Lukachova LV, Gorton L, Laurell T, Karyakin AA (2001) Evaluation of glucose biosensors based on Prussian blue and lyophilised, crystalline, and cross-linked glucose oxidases (CLEC®). Talanta 54:963–974
Hodak J, Etchenique R, Calvo EJ, Singhal K, Bartlett PN (1997) Layer-by-layer self-assembly of glucose oxidase with a poly(allylamine)ferrocene redox mediator. Langmuir 13:2708–2716
Guo C, Zhang X, Huo H, Xu C, Han X (2013) Co3O4 microspheres with free-standing nanofibers for high performance nonenzymatic glucose sensor. Analyst 138:6727–6731
Ramakrishna S, Mayer J, Wintermantel E, Leong KW (2001) Biomedical applications of polymer-composite materials: a review. Compos Sci Technol 61:1189–1224
Balazs AC, Emrick T, Russell TP (2006) Nanoparticle polymer composites: where two small worlds meet. Science 314:1107–1110
Sun HZ, Yang B (2008) In situ preparation of nanoparticles/polymer composites. Sci Chin Ser E-Technol Sci 51:1886–1901
Schmidt G, Malwitz MM (2003) Properties of polymer–nanoparticle composites. Curr Opin Colloid Interface Sci 8:103–108
Vauthier C, Cabane B, Labarre D (2008) How to concentrate nanoparticles and avoid aggregation? Eur J Pharm Biopharm 69:466–475
Mathew M, Sandhyarani N (2014) Detection of glucose using immobilized bienzyme on cyclic bisureas-gold nanoparticle conjugate. Anal Biochem 459:31–38
Jin C, Taniguchi I (2007) Electrocatalytic oxidation of glucose on gold nanocomposite electrodes. Chem Eng Technol 30:1298–1301
Li C, Su Y, Lv X, Xia H, Shi H, Yang X, Zhang J, Wang Y (2012) Controllable anchoring of gold nanoparticles to polypyrrole nanofibers by hydrogen bonding and their application in nonenzymatic glucose sensors. Biosens Bioelectron 38:402–406
Raicopol M, Prună A, Damian C, Pilan L (2013) Functionalized single-walled carbon nanotubes/polypyrrole composites for amperometric glucose biosensors. Nanoscale Res Lett 8:316
Forzani ES, Zhang H, Nagahara LA, Amlani I, Tsui R, Tao N (2004) A conducting polymer nanojunction sensor for glucose detection. Nano Lett 4:1785–1788
Nien PC, Tung TS, Ho KC (2006) Amperometric glucose biosensor based on entrapment of glucose oxidase in a poly(3,4-ethylenedioxythiophene) film. Electroanalysis 18:1408–1415
Yang G, Kampstra KL, Abidian MR (2014) High-performance conducting polymer nanofiber biosensors for detection of biomolecules. Adv Mater 26:4954–4960
Macaya DJ, Nikolou M, Takamatsu S, Mabeck JT, Owens RM, Malliaras GG (2007) Simple glucose sensors with micromolar sensitivity based on organic electrochemical transistors. Sensors Actuators B Chem 123:374–378
Zhang M, Liao C, Mak CH, You P, Mak CL, Yan F (2015) Highly sensitive glucose sensors based on enzyme-modified whole-graphene solution-gated transistors. Sci Rep 5:8311
Olenic L, Mihailescu G, Pruneanu S, Lupu D, Biris AR, Margineanu P, Garabagiu S, Biris AS (2009) Investigation of carbon nanofibers as support for bioactive substances. J Mater Sci Mater Med 20:177–183
Periasamy AP, Chang YJ, Chen SM (2011) Amperometric glucose sensor based on glucose oxidase immobilized on gelatin-multiwalled carbon nanotube modified glassy carbon electrode. Bioelectrochemistry 80:114–120
Wu S, Ju HX, Liu Y (2007) Conductive mesocellular silica-carbon nanocomposite foams for immobilization, direct electrochemistry, and biosensing of proteins. Adv Funct Mater 17:585–592
Liu Y, Teng H, Hou H, You T (2009) Nonenzymatic glucose sensor based on renewable electrospun Ni nanoparticle-loaded carbon nanofiber paste electrode. Biosens Bioelectron 24:3329–3334
Zhang L, Li Y, Zhang Q, Wang H (2013) Hierarchical nanostructure of WO3 nanorods on TiO2 nanofibers and the enhanced visible light photocatalytic activity for degradation of organic pollutants. Cryst Eng Comm 15:5986–5993
Ostermann R, Li D, Yin Y, McCann JT, Xia Y (2006) V2O5 nanorods on TiO2 nanofibers: a new class of hierarchical nanostructures enabled by electrospinning and calcination. 6:1297–1302
Li M, Liu L, Xiong Y, Liu X, Nsabimana A, Bo X, Guo L (2015) Bimetallic MCo (M = Cu, Fe, Ni, and Mn) nanoparticles doped-carbon nanofibers synthetized by electrospinning for nonenzymatic glucose detection. Sensors Actuators B Chem 207:614–622
Uzun SD, Kayaci F, Uyar T, Timur S, Toppare L (2014) Bioactive surface design based on functional composite electrospun nano fibers for biomolecule immobilization and biosensor applications. ACS Appl Mater Interfaces 6:5235–5243
Zhao M, Gao Y, Sun J, Gao F (2015) Mediatorless glucose biosensor and direct electron transfer type glucose/air biofuel cell enabled with carbon nanodots. Anal Chem 87:2615–2622
Cai C, Chen J (2004) Direct electron transfer of glucose oxidase promoted by carbon nanotubes. Anal Biochem 332:75–83
Zhang X, Liu D, Li L, You T (2015) Direct electrochemistry of glucose oxidase on novel free-standing nitrogen-doped carbon nanospheres@carbon nanofibers composite film. Sci Rep 5:9885
Anitha S, Natarajan TS (2013) Fabrication of hierarchical ZnO enriched fibrous PVA membrane. J Nanosci Nanotechnol 13:4256–4264
Anitha S, Thiruvadigal DJ, Natarajan TS (2011) In-situ preparation of high optical quality ZnO nanoparticles in nanofibrous PVA matrix. Mater Lett 65:2872–2876
Yuan Y, Zhao Y, Li H, Li Y, Gao X, Zheng C, Zhang J (2012) Electrospun metal oxide–TiO2 nanofibers for elemental mercury removal from flue gas. J Hazard Mater 227–228:427–435
Horzum N, Muñoz-Espí R, Glasser G, Demir MM, Landfester K, Crespy D (2012) Hierarchically structured metal oxide/silica nanofibers by colloid electrospinning. ACS Appl Mater Interfaces 4:6338–6345
Hwang SH, Song J, Jung Y, Kweon OY, Song H, Jang J (2011) Electrospun ZnO/TiO2 composite nanofibers as a bactericidal agent. Chem Commun 47:9164–9166
Wang W, Li Z, Zheng W, Dong B, Li S, Wang C (2010) A novel nonenzymatic glucose sensor based on nickel (II) oxide electrospun nanofibers. J Nanosci Nanotechnol 10:7537–7540
Zheng B, Liu G, Yao A, Xiao Y, Du J, Guo Y, Xiao D, Hu Q, Choi MMF (2014) A sensitive AgNPs/CuO nanofibers nonenzymatic glucose sensor based on electrospinning technology. Sensors Actuators B Chem 195:431–438
Ahmad M, Pan C, Luo Z, Zhu J (2010) A single ZnO nanofiber-based highly sensitive amperometric glucose biosensor. J Phys Chem C 114:9308–9313
Lu N, Shao C, Li X, Shen T, Zhang M, Miao F, Zhang P, Zhang X, Wang K, Zhang Y, Liu Y (2014) CuO/Cu2O nanofibers as electrode materials for nonenzymatic glucose sensors with improved sensitivity. RSC Adv 4:31056–31061
Kayaci F, Ozgit-Akgun C, Biyikli N, Uyar T (2013) Surface-decorated ZnO nanoparticles and ZnO nanocoating on electrospun polymeric nanofibers by atomic layer deposition for flexible photocatalytic nanofibrous membranes. RSC Adv 3:6817–6820
Deniz AE, Celebioglu A, Kayaci F, Uyar T (2011) Electrospun polymeric nanofibrous composites containing TiO2 short nanofibers. Mater Chem Phys 129:701–704
Khalil A, Dimas C, Hashaikeh R (2015) Electrospun copper oxide nanofibers as infrared photodetectors. Appl Phys A 118:217–224
Zhou X, Qiu Y, Yu J, Yin J, Bai X (2012) High electrochemical activity from hybrid materials of electrospun tungsten oxide nanofibers and carbon black. J Mater Sci 47:6607–6613
Katoch A, Choi SW, Kim SS (2015) Nanograins in electrospun oxide nanofibers. Met Mater Int 21:213–221
Kim HK, Honda W, Kim BS, Kim IS (2013) Preparation and magnetic properties of electrospun CuO/NiO bimetallic nanofibers via sol-gel electrospinning. J Mater Sci 48:1111–1116
Ding Y, Wang Y, Su L, Zhang H, Lei Y (2010) Preparation and characterization of NiO–Ag nanofibers, NiO nanofibers, and porous Ag: towards the development of a highly sensitive and selective nonenzymatic glucose sensor. J Mater Chem 20:9918–9926
Cao F, Gong J (2012) Nonenzymatic glucose sensor based on CuO microfibers composed of CuO nanoparticles. Anal Chim Acta 723:39–44
Song Y, Li X, Wei C, Fu J, Xu F, Tan H, Tang J, Wang L (2015) A green strategy to prepare metal oxide superstructure from metal-organic frameworks. Sci Rep 5:8401
Zhou C, Xu L, Song J, Xing R, Xu S, Liu D, Song H (2014) Ultrasensitive nonenzymatic glucose sensor based on three-dimensional network of ZnO-CuO hierarchical nanocomposites by electrospinning. Sci Rep 4:7382
Anitha S, Thiruvadigal DJ, Natarajan TS (2011) A study on defect controlled morphology of organic/inorganic composite nanofibers with different heat flow rates. Mater Lett 65:167–170
Wang W, Zhang L, Tong S, Li X, Song W (2009) Three-dimensional network films of electrospun copper oxide nanofibers for glucose determination. Biosens Bioelectron 25:708–714
Liu G, Zheng B, Jiang Y, Cai Y, Du J, Yuan H, Xiao D (2012) Improvement of sensitive CuO NFs-ITO nonenzymatic glucose sensor based on in situ electrospun fiber. Talanta 101:24–31
Pickup JC, Hussain F, Evans ND, Rolinski OJ, Birch DJS (2005) Fluorescence-based glucose sensors. Biosens Bioelectron 20:2555–2565
Xia Y, Ye J, Tan K, Wang J, Yang G (2013) Colorimetric visualization of glucose at the submicromole level in serum by a homogenous silver nanoprism-glucose oxidase system. Anal Chem 85:6241–6247
Zhao W, Brook MA, Li Y (2008) Design of gold nanoparticle-based colorimetric biosensing assays. Chem Biol Chem 9:2363–2371
Wang XD, Chen HX, Zhou TY, Lin ZJ, Zeng JB, Xie ZX, Chen X, Wong KY, Chen GN, Wang XR (2009) Optical colorimetric sensor strip for direct readout glucose measurement. Biosens Bioelectron 24:3702–3705
Xu X, Yang X (2011) Facile colorimetric detection of glucose based on an organic Fenton reaction. Anal Methods 3:1056–1059
Senthamizhan A, Celebioglu A, Uyar T (2015) Real-time selective visual monitoring of Hg2+ detection at ppt level: an approach to lighting electrospun nanofibers using gold nanoclusters. Sci Rep 5:10403
Chen LY, Wang CW, Yuan Z, Chang HT (2015) Fluorescent gold nanoclusters: recent advances in sensing and imaging. Anal Chem 87:216–229
Basabe-Desmonts L, Reinhoudt DN, Crego-Calama M (2007) Design of fluorescent materials for chemical sensing. Chem Soc Rev 36:993–1017
Song Y, Wei W, Qu X (2011) Colorimetric biosensing using smart materials. Adv Mater 23:4215–4236
Costa MN, Veigas B, Jacob JM, Santos DS, Gomes J, Baptista PV, Martins R, Inácio J, Fortunato E (2014) A low cost, safe, disposable, rapid and self-sustainable paper-based platform for diagnostic testing: lab-on-paper. Nanotechnology 25:094006
Takatsuji Y, Yamasaki R, Iwanaga A, Lienemann M, Linder MB, Haruyama T (2013) Solid-support immobilization of a “swing” fusion protein for enhanced glucose oxidase catalytic activity. Colloids Surf B: Biointerfaces 112:186–191
Snejdárková M, Rehák M, Otto M (1993) Design of a glucose minisensor based on streptavidin-glucose oxidase complex coupling with self-assembled biotinylated phospholipid membrane on solid support. Anal Chem 65:665–668
Ji X, Su Z, Wang P, Ma G, Zhang S (2014) “Ready-to-use” hollow nanofiber membrane-based glucose testing strips. Analyst 139:6467–6473
Zhou C, Shi Y, Ding X, Li M, Luo J, Lu Z, Xiao D (2013) Development of a fast and sensitive glucose biosensor using iridium complex-doped electrospun optical fibrous membrane. Anal Chem 85:1171–1176
Wang J (2008) In vivo glucose monitoring: towards “sense and act” feedback-loop individualized medical systems. Talanta 75:636–641
Pickup JC, Hussain F, Evans ND, Sachedina N (2005) In vivo glucose monitoring: the clinical reality and the promise. Biosens Bioelectron 20:1897–1902
Jiang Y, Zhao H, Lin Y, Zhu N, Ma Y, Mao L (2010) Colorimetric detection of glucose in rat brain using gold nanoparticles. Angew Chem Int Ed 49:4800–4804
Shichiri M, Kawamori R, Yamasaki Y, Hakui N, Abe H (1982) Wearable artificial endocrine pancrease with needle-type glucose sensor. Lancet 2:1129–1131
Ozaydin-Ince G, Dubach JM, Gleason KK, Clark HA (2011) Microworm optode sensors limit particle diffusion to enable in vivo measurements. Proc Natl Acad Sci U S A 108:2656–2661
Pleitez MA, Lieblein T, Bauer A, Hertzberg O, Lilienfeld-Toal HV, Mäntele W (2013) In vivo noninvasive monitoring of glucose concentration in human epidermis by mid-infrared pulsed photoacoustic spectroscopy. Anal Chem 85:1013–1020
Nakayama D, Takeoka Y, Watanabe M, Kataoka K (2003) Simple and precise preparation of a porous gel for a colorimetric glucose sensor by a templating technique. Angew Chem Int Ed 42:4197–4200
Heo YJ, Shibata H, Okitsu T, Kawanishi T, Takeuchi S (2011) Long-term in vivo glucose monitoring using fluorescent hydrogel fibers. Proc Natl Acad Sci U S A 108:13399–13403
Yoon J, Czarnik AW (1992) Fluorescent chemosensors of carbohydrates. A means of chemically communicating the binding of polyols in water based on chelation-enhanced quenching. J Am Chem Soc 114:5874–5875
Balaconis MK, Luo Y, Clark HA (2015) Glucose-sensitive nanofiber scaffolds with an improved sensing design for physiological conditions. Analyst 140:716–723
Acknowledgments
S.A. and B.B. thank the Scientific and Technological Research Council of Turkey (TÜBITAK) (TÜBITAK-BIDEB 2216, Research Fellowship Programme for Foreign Citizens) for postdoctoral fellowship funding. T.U. acknowledges partial support of The Turkish Academy of Sciences – Outstanding Young Scientists Award Program (TUBA-GEBIP).
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Published in the topical collection Fiber-based Platforms for Bioanalytics with guest editors Antje J. Baeumner and R. Kenneth Marcus.
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Senthamizhan, A., Balusamy, B. & Uyar, T. Glucose sensors based on electrospun nanofibers: a review. Anal Bioanal Chem 408, 1285–1306 (2016). https://doi.org/10.1007/s00216-015-9152-x
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DOI: https://doi.org/10.1007/s00216-015-9152-x