Abstract
Maghemite and cobalt ferrite anionic magnetic nanoparticles enter tumor cells and can be used as heat sources when exposed to a high-frequency magnetic field. Comparative studies of the two particles enable to unravel the magnetic heating mechanisms (Néel relaxation vs. Brown relaxation) responsible for the cellular temperature rise, and also to establish a simple model, adjusted to the experimental results, allowing to predict the intracellular heating efficiency of iron oxide nanoparticles. Hence, we are able to derive the best nanoparticle design for a given material with a view to intracellular hyperthermia-based applications.
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Acknowledgments
We thank Jean-Claude Bacri for fruitful discussions, Christine Ménager and Sophie Neveu for providing us with the nanoparticles, Christine Longin and Sophie Chat for assistance in electron microscopy and Jacques Servais for technical help. This work was supported by ACI n°145 NANOSCIENCE of the French Ministry of research.
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Fortin, JP., Gazeau, F. & Wilhelm, C. Intracellular heating of living cells through Néel relaxation of magnetic nanoparticles. Eur Biophys J 37, 223–228 (2008). https://doi.org/10.1007/s00249-007-0197-4
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DOI: https://doi.org/10.1007/s00249-007-0197-4