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Microbial enzymes involved in lactone compound metabolism and their biotechnological applications

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Abstract

Lactone compounds are widely distributed in nature and play important roles in organisms. These compounds are synthesized and metabolized enzymatically in vivo; however, detailed investigation of these enzymes lags behind that of other common enzymes. In this paper, recent work on the enzymes involved in the metabolism of lactone compounds will be reviewed. In particular, fundamental and application studies on lactonases and Baeyer-Villiger monooxgenases of microbial origin are described.

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Acknowledgements

This work was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. This work was also carried out as part of the Project for “Development of a Technological Infrastructure for Industrial Bioprocesses on R&D of New Industrial Science and Technology Frontiers” of the Ministry of Economy, Trade & Industry (METI) and the New Energy and Industrial Technology Development Organization (NEDO, to SS).

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  1. Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan

    Michihiko Kataoka, Kohsuke Honda & Sakayu Shimizu

  2. Daiichi Fine Chemical Co., Takaoka, Toyama, 933-8511, Japan

    Keiji Sakamoto

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  1. Michihiko Kataoka
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  2. Kohsuke Honda
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  3. Keiji Sakamoto
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  4. Sakayu Shimizu
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Correspondence to Sakayu Shimizu.

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Kataoka, M., Honda, K., Sakamoto, K. et al. Microbial enzymes involved in lactone compound metabolism and their biotechnological applications. Appl Microbiol Biotechnol 75, 257–266 (2007). https://doi.org/10.1007/s00253-007-0896-x

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