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Polymer Bulletin
Erschienen in: Polymer Bulletin 7/2014

01.07.2014 | Original Paper

Biodegradable polymeric microspheres of gelatin and carboxymethyl guar gum for controlled release of theophylline

verfasst von: Keerti V. Phadke, Lata S. Manjeshwar, Tejraj M. Aminabhavi

Erschienen in: Polymer Bulletin | Ausgabe 7/2014

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Abstract

Carboxymethyl guar gum (CMGG) was synthesized by carboxymethylation of guar gum (GG), which was blended with gelatin (GE) to obtain a novel semi-interpenetrating polymer network (semi-IPN) in the form of microspheres prepared by water-in-oil emulsion method to investigate the controlled release of theophylline (THP), an antiasthmatic drug. Electronic spectroscopy revealed the drug encapsulation ranging from 56 to 74 %. Fourier Transform infrared spectroscopy confirmed the carboxymethylation of GG as well as the semi-IPN structure of the blend polymer. Scanning electron microscopy indicated the smooth surfaces with spherical microspheres. Differential scanning calorimetric and X-ray diffraction studies showed the molecular level dispersion of drug in the microspheres. The in vitro drug release profiles were analyzed to study the effect of polymer blend composition, % drug loading and amount of glutaraldehyde added as a crosslinker. The drug release was extended up to 26 h. The in vitro release data performed in acidic and alkaline media were analyzed using the empirical equations to understand the release profiles of THP.
Vorheriger Artikel Sonochemical deposition of silver nanoparticles on linear low density polyethylene/cyclo olefin copolymer blend films
Nächster Artikel Characterization of the anionic polymerization of 2-(ethoxy)ethyl methacrylate by t-C4H9MgBr in toluene

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Metadaten
Titel
Biodegradable polymeric microspheres of gelatin and carboxymethyl guar gum for controlled release of theophylline
verfasst von
Keerti V. Phadke
Lata S. Manjeshwar
Tejraj M. Aminabhavi
Publikationsdatum
01.07.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 7/2014
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-014-1145-y

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