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Combined effect of Neridronate and specific antibiotic therapy in a case of tuberculous spondylodiscitis

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Abstract

Because of the increased incidence of tuberculosis (TB) in recent years, infective spondylitis is still a major problem in the world. In skeletal TB the spine is the most often involved and lumbosacral spine involvement is rare. Nowadays early diagnosis and new medical treatment can reduce the incidence of the serious skeletal sequelae and the number of surgery procedures in spinal TB. We present a case of TB spondylodiscitis characterized by a rapid and progressive clinical and radiological improvement after treatment with Neridronate and chemotherapic drugs. Our data suggest that in the treatment of the TB spondylodiscitis the combined use of these drugs is a good alternative to stimulate bone reparative process to the chemotherapy alone. To our knowledge this is first case of a patient with TB discitis treated with Neridronate. Further studies are necessary to confirm the effectiveness of Neridronate treatment added to antiTB drugs in spondylodiscitis

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References

  1. Tali ET (2004) Spinal infections. Eur J Radiol 50:120–133

    Article  PubMed  Google Scholar 

  2. CDC (2003) Guidelines for using the QuantiFERON®-TB test for diagnosing latent Mycobacterium tuberculosis infection. MMWR 52(No. RR-2):15–18

  3. CDC (2005) Guidelines for Using the QuantiFERON®-TB Gold Test for Detecting Mycobacterium tuberculosis Infection, United State-Recommendations and Reports. MMWR 54(RR15):49–55

  4. Golden MP, Vikram HR (2005) Extrapulmonary tuberculosis: an overview. Am Fam Physician 72:1761–1768

    PubMed  Google Scholar 

  5. Grosskopf I, Ben David A, Charach G, Hochman I, Pitlik S (1994) Bone and joint tuberculosis-a 10-year review. Isr J Med Sci 30:278–283

    PubMed  CAS  Google Scholar 

  6. Resnick D, Kransdorf MJ (2005) Osteomielitis, septic arthritis and soft tissue infection: organism. Elservier/Saunders, Amsterdam

  7. Abhay N, Shekhar B (2005) Results of nonsurgical treatment of thoracic spinal tuberculosis in adults. Spine J 5:79–84

    Article  Google Scholar 

  8. Gillespie SH, Billington O (1999) Activity of moxifloxacin against mycobacteria. J Antimicrob Chemother 44:395

    Article  Google Scholar 

  9. Gillespie SH, Morrissey I, Everett D (2001) A comparison of the bactericidal activity of quinolone antibiotics in a Mycobacterium fortuitum model. J Med Microbiol 50:565–570

    PubMed  CAS  Google Scholar 

  10. Ji B, Lounis N, Truffot-Pernot C, Grosset J (1995) In vitro and in vivo activities of levofloxacin against Mycobacterium tuberculosis. Antimicrob Agents Chemother 39:1341–1344

    PubMed  CAS  Google Scholar 

  11. Kennedy N, Berger L, Curram J et al (1996) Randomized controlled trial of a drug regimen that includes ciprofloxacin for the treatment of pulmonary tuberculosis. Clin Infect Dis 22:827–833

    PubMed  CAS  Google Scholar 

  12. Khokher MA, Dandona P (1989) Bisphosphonates inhibit human osteoblast secretion and proliferation. Metabolism 38:184–187

    Article  PubMed  CAS  Google Scholar 

  13. Vitte C, Fleisch H, Guenther HL (1996) Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption. Endocrinology 137:2324–2333

    Article  PubMed  CAS  Google Scholar 

  14. Frediani B, Spreafico A, Capperucci C, Chellini F, Gambera D, Ferrata P et al (2004) Long-term effects of Neridronate on human osteoblastic cell cultures. Bone 35(4):859–869

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Rheumatology, University of Foggia Medical School, Foggia, Italy

    L. Quarta, A. Corrado, N. Melillo, A. Trotta, F. d’Onofrio, N. Santoro & F. P. Cantatore

  2. Department of Infectious Disease, “Riuniti” Hospital, Foggia, Italy

    G. Scotto

  3. Rheumatology Clinic “Mario Carrozzo”, “D’Avanzo” Hospital, Viale degli Aviatori, 1, 71100, Foggia, Italy

    F. P. Cantatore

Authors
  1. L. Quarta
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  2. A. Corrado
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  3. N. Melillo
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  4. A. Trotta
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  5. G. Scotto
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  6. F. d’Onofrio
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  7. N. Santoro
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  8. F. P. Cantatore
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Correspondence to F. P. Cantatore.

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Quarta, L., Corrado, A., Melillo, N. et al. Combined effect of Neridronate and specific antibiotic therapy in a case of tuberculous spondylodiscitis. Rheumatol Int 28, 495–498 (2008). https://doi.org/10.1007/s00296-007-0460-0

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  • DOI: https://doi.org/10.1007/s00296-007-0460-0

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